Acetylcholinesterase and Neuropathy Target Esterase Inhibitions in Neuroblastoma Cells to Distinguish Organophosphorus Compounds Causing Acute and Delayed Neurotoxicity,

Ehrich, Marion

doi:10.1006/faat.1997.2330

Cited by 96 publications

(108 citation statements)

References 24 publications

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“…This number has been shown to be significantly greater than 1 and not different statistically from the RIP value of 179 for CPO. Given that RIP values of this magnitude correlate with the inability of the inhibitor itself or its parent compound to cause OPIDN at less than lethal doses (Capodicasa et al, 1991;Ehrich et al, 1997;Lotti & Johnson, 1978;Richardson, 1992Richardson, , 1995Richardson et al, 1993), an important conclusion that may be drawn from the results of the present study is that CPMS, like its analogue CPS, cannot produce OPIDN at sublethal doses.…”

Section: Notementioning

confidence: 60%

“…All these I 50 values for MIP against NTE are in excellent agreement with the value of 6.96 µM determined for hen brain microsomal NTE in the present study. Of particular interest for the present study, Ehrich et al (1997) found RIP values for MIP and CPO in mouse neuroblastoma cells to be 2.6 and 87, respectively. In human neuroblastoma cells, these authors found RIP values for MIP and CPO of 1.1 and 200, respectively.…”

Section: Notementioning

confidence: 64%

“…MIP, an OP compound known to produce OPIDN (Davis et al, 1985), was included for contrast. Previous work indicated that MIP would have comparable inhibitory potencies for AChE and NTE, and would be far less potent against either enzyme than CPO or CPMO (Ehrich et al, 1997;Kropp & Richardson, 2002;Lotti & Johnson, 1978). Adult hen brain was used as the enzyme source in the present study, because assays of brain AChE and NTE from this species are required by domestic (U.S. EPA, 1998) and international (OECD, 1995a(OECD, , 1995b regulatory agencies for neurotoxicity testing of OP compounds.…”

mentioning

confidence: 99%

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Relative Inhibitory Potencies of Chlorpyrifos Oxon, Chlorpyrifos Methyl Oxon, and Mipafox for Acetylcholinesterase Versus Neuropathy Target Esterase

Kropp

Richardson

2003

Journal of Toxicology and Environmental Health, Part A

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Section: Notementioning

confidence: 60%

Section: Notementioning

confidence: 64%

mentioning

confidence: 99%

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Relative Inhibitory Potencies of Chlorpyrifos Oxon, Chlorpyrifos Methyl Oxon, and Mipafox for Acetylcholinesterase Versus Neuropathy Target Esterase

Kropp

Richardson

2003

Journal of Toxicology and Environmental Health, Part A

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“…As the differential inhibition of the target esterases (acetylcholinesterase and NTE) by OP compounds is followed by distinct neurological consequences in exposed subjects, it is useful to distinguish between the neurotoxic (inhibitors of acetylcholinesterase) and neuropathic (inhibitors of NTE) OP agents. Mouse or human neuroblastoma cell lines are considered to be useful in vitro models in distinguishing between the esterase-inhibiting OP agents [74].…”

Section: Delayed Polyneuropathymentioning

confidence: 99%

Organophosphorus poisoning and anaesthesia

1999

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SummaryOrganophosphorus compounds, used as insecticides and agents of chemical warfare, are a major global cause of health problems. These irreversible inhibitors of cholinesterase produce three wellrecognised clinical entities: the initial cholinergic phase, which is a medical emergency often requiring management in an intensive care unit; the intermediate syndrome, during which prolonged ventilatory care is necessary; and delayed polyneuropathy. In addition, disturbances of body temperature and endocrine function, electrolyte imbalances, immunological dysfunction and disorders of reproduction have been reported in animals and man. Vocal cord paralysis, pancreatitis, cardiac arrhythmias and a wide range of neuropsychiatric disorders are known to follow acute and chronic exposure to organophosphorus compounds. As a result of the inhibition of plasma cholinesterase, there can be increased sensitivity to drugs hydrolysed by this enzyme, e.g. suxamethonium and mivacurium. The inhibition of acetylcholinesterase causes dysfunction at the neuromuscular junction which can produce altered responses to nondepolarising neuromuscular blockers. Anaesthetists may encounter patients exposed to organophosphorus compounds either following acute poisoning, trauma (warfare) or as patients with a wide range of nonspecific disorders presenting for surgery. The traditional use of oximes and atropine in treatment has failed to reduce the morbidity and mortality associated with poisoning. The roles of agents that have reduced the toxicity of organophosphorus compounds in animal experiments are discussed as potential therapeutic agents. There is an urgent need for accurate information on the problems associated with exposure to organophosphorus compounds. This would best be achieved by collaborative research between technologically advanced countries and developing countries, where organophosphorus compounds are a leading cause of ill health.

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“…Although all of them can bind to acetylcholine esterase at nerve terminals, each of them might have different additional targets and target organs. For instance, only a subgroup affects neuropathy target esterase and causes delayed neuropathy (Emerick et al 2012;Ehrich et al 1997). Some organophosphates may be involved in inflammation or inflammatory diseases such as asthma (Proskocil et al 2013;Banks and Lein 2012).…”

mentioning

confidence: 99%

Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing

et al. 2013

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Acetylcholinesterase and Neuropathy Target Esterase Inhibitions in Neuroblastoma Cells to Distinguish Organophosphorus Compounds Causing Acute and Delayed Neurotoxicity,

Cited by 96 publications

References 24 publications

Relative Inhibitory Potencies of Chlorpyrifos Oxon, Chlorpyrifos Methyl Oxon, and Mipafox for Acetylcholinesterase Versus Neuropathy Target Esterase

Relative Inhibitory Potencies of Chlorpyrifos Oxon, Chlorpyrifos Methyl Oxon, and Mipafox for Acetylcholinesterase Versus Neuropathy Target Esterase

Organophosphorus poisoning and anaesthesia

Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing

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