Acetylcholinesterase activity of electric eel is increased or decreased by selected monoterpenoids and phenylpropanoids in a concentration-dependent manner

López, María Dolores; Campoy, Francisco J.; Pascual‐Villalobos, M. J.; Muñoz-Delgado, Encarnación; Vidal, Cecilio J.

doi:10.1016/j.cbi.2015.01.006

Cited by 44 publications

(33 citation statements)

References 49 publications

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“…The Lineweaver-Burk methodology indicated that both samples presented inhibition of competitive mixed-type, with K i values of 265 µM and 262 µM, respectively. López, Campoy, Pascual-Villalobos, Muñoz-Delgado, and Vidal (2015) studied the inhibition of AChE activity of the electric eel by monoterpenoids and phenylpropanoids, finding that these compounds may be considered weaker inhibitors than known alkaloids such as galanthamine. The essential oil of Salvia lavandulaefolia and its main constituents (αpinene, 1,8-cineole, and camphor) were found to be uncompetitive reversible inhibitors for the activity of human erythrocyte AChE.…”

Section: Ache Activity Assay and Reaction Kineticsmentioning

confidence: 99%

Influence of nanoencapsulated lutein on acetylcholinesterase activity: In vitro determination, kinetic parameters, and in silico docking simulations

et al. 2020

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A B S T R A C TLutein is a bioactive found in dark leafy vegetables that may be used as a nutraceutical agent in foodstuff and an inhibitor of key enzymes of the human body such as those involved in the cholinergic system. However, its high hydrophobicity leads to low bioavailability and must be overcome if lutein is to be added in foods. The objective of this study was to evaluate the influence of nanoencapsulated lutein in the activity of the acetylcholinesterase enzyme. The in vitro study was carried out using water in order to evaluate the impact of encapsulation on the hydrophilicity of lutein. In vitro assays showed that lutein, both free and nanoencapsulated, presented a mixedtype inhibition behavior, and encapsulated lutein was able to inhibit acetylcholinesterase activity even in an aqueous medium. Inhibition was also showed by the in silico docking results which show that lutein interacted with the pocket region of the enzyme. that the damage to the cholinergic system is closely related to brain dysfunctions such as affective disorders, depression, schizophrenia and https://doi.

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Section: Ache Activity Assay and Reaction Kineticsmentioning

confidence: 99%

Influence of nanoencapsulated lutein on acetylcholinesterase activity: In vitro determination, kinetic parameters, and in silico docking simulations

et al. 2020

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“…praeteritum oils for anti-neurodegenerative activity via inhibition of acetylcholinesterase revealed that the oil A showed higher inhibitory effect with an IC50 of 0.74 mg/mL than the oil B (IC50 of 1.78 mg/mL). Anti-cholinesterase effects of 1,8-cineole, camphor and terpinen-4-ol which were the main constituents of the oil A have earlier been reported in a number of papers (34,(64)(65)(66).…”

Section: Free Radical Scavenging Activity (Dpph Assay)mentioning

confidence: 79%

Chemical Diversity and Biological Potential of Tanacetum praeteritum subsp. praeteritum Essential Oils

Özek

2018

Journal of the Turkish Chemical Society Section A: Chemistry

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Two samples of Tanacetum praeteritum (Horwood) Heywood subsp. praeteritum (Horwood) were collected in flowering period and subjected separately to hydrodistillation to yield the essential oils (A and B). The oils were investigated for chemical composition with GC-FID and GC/MS techniques and evaluated against acetylcholinesterase and -amylase enzymes and free radicals (DPPH • and ABTS •+ ) using microtiter plate assays. Both oils were characterized with high abundance of oxygenated monoterpenes. The oils were distinguished by the main constituents, namely, camphor (37.6%), 1,8-cineole (19.5%) and terpinen-4-ol (9.3%) were found as the major constituents in the oil A, while -thujone (79.4%) and -thujone (8.5%) were detected in the oil B. The oils demonstrated significant inhibitory (80% and 60.0%) potentials on acetylcholinesterase (an IC50 of 0.74 mg/mL and an IC50 of 1.78 mg/mL, respectively) which is involved in Alzheimer's disease. With respect to antidiabetic activity, the oils demonstrated significant inhibiting potential on porcine pancreatic -amylase (an IC50 of 1.02 mg/mL and an IC50 of 0.89 mg/mL) in I2/KI assay. The oils demonstrated weak free radical scavenging activity against DPPH radicals and moderate activity (0.23 mM and 0.15 mM) against ABTS +• in TEAC assay.

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“…Among volatile compounds identified as components of tested oil, several compounds were previously tested on AChE inhibition. Among them, β-ionone, verbenone, geraniol and α-terpineol showed good AChE inhibition potential [8][9][10][11][12][13]. These compounds or synergism of these compounds are probably responsible for low to moderate, but noticeable, AChE inhibition activity of tested oil.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Acetylcholinesterase Inhibition Activity of Volatile Oil from Leaves of Arbutus unedo L. from Croatia

Politeo

Ercegovic

2019

Asian J. Chem.

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The volatile oil from leaves of Arbutus unedo L. from Croatia was subjected to chemical composition and acetylcholinesterase inhibition activity. The tested volatile oil was dominated by nonterpene compounds, with (E)-2-decenal, nonanal, nonanoic acid and octanol as main compounds. Terpene compounds were identified in lower quantity, with linalool and α-terpineol as main ones. Results showed low to moderate acetylcholinesterase (AChE) inhibition potential of tested oil, for tested concentration of 1 mg/mL.

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Acetylcholinesterase activity of electric eel is increased or decreased by selected monoterpenoids and phenylpropanoids in a concentration-dependent manner

Cited by 44 publications

References 49 publications

Influence of nanoencapsulated lutein on acetylcholinesterase activity: In vitro determination, kinetic parameters, and in silico docking simulations

Influence of nanoencapsulated lutein on acetylcholinesterase activity: In vitro determination, kinetic parameters, and in silico docking simulations

Chemical Diversity and Biological Potential of Tanacetum praeteritum subsp. praeteritum Essential Oils

Chemical Composition and Acetylcholinesterase Inhibition Activity of Volatile Oil from Leaves of Arbutus unedo L. from Croatia

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