Acetyl-11-keto-β-boswellic acid modulates membrane dynamics in benzo(a)pyrene-induced lung carcinogenesis

Bhardwaj, Priti; Kumar, Manoj; Dhatwalia, Sunil Kumar; Garg, M. L.; Dhawan, D. K.

doi:10.1007/s11010-019-03566-z

Cited by 11 publications

(10 citation statements)

References 42 publications

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“…Similarly, antioxidant effects of AKBA have been previously reported. Manoj Kumar et al have demonstrated that AKBA inhibits benzo (a) pyrene-induced liver toxicity by reducing NO generation [ 55 ]. Besides, Yu et al investigated the nitric oxide inhibitory activity of bioactive compounds isolated from the resin of Boswellia carteri .…”

Section: Discussionmentioning

confidence: 99%

Acetyl-11-Keto-β-Boswellic Acid (AKBA) Prevents Lipopolysaccharide-Induced Inflammation and Cytotoxicity on H9C2 Cells

Taherzadeh

Rahimi

Amiri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Acetyl-11-keto-beta-boswellic acid (AKBA), the major component of Boswellia serrata, exhibits anti-inflammatory activities. This in vitro study investigated the protective effects of AKBA against lipopolysaccharide (LPS)-induced cardiac dysfunction. In this study, the H9C2 cardiomyocytes were pretreated with AKBA (2.5, 5, and 10 μM for 24 h), and then cotreated with LPS for another 24 h. The MTT assay, ELISA test kits, and quantitative real-time PCR analysis assessed the cell viability, levels of proinflammatory factors (IL-β, IL-6, TNF- α, and PGE2), and the gene expression of IL-β, IL-6, TNF- α, iNOS, and COX-2, respectively. The nitric oxide (NO) and thiol levels were also measured using a biochemical assay. The results indicated that LPS exposure markedly reduced cell viability and total thiol content, but increased the inflammatory cytokines, NO metabolites, and gene expression of proinflammatory mediators in H9C2 cells. AKBA pretreatment significantly altered the mentioned factors induced by LPS. Our results demonstrated that AKBA might be a promising therapeutic agent for treating sepsis-related cardiac dysfunction in the future.

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Section: Discussionmentioning

confidence: 99%

Acetyl-11-Keto-β-Boswellic Acid (AKBA) Prevents Lipopolysaccharide-Induced Inflammation and Cytotoxicity on H9C2 Cells

Taherzadeh

Rahimi

Amiri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…The steady-state polarization of 1, 6-diphenyl-1,3,5-hexatriene (DPH) was employed to examine the rotational diffusion and order parameter of the membrane (short-range order). The polarization of the fluorescence of a molecule relies on the rate of rotation where the binding of the fluorophore to the biological membrane can be analyzed by a rise in the polarization of the fluorescence probe [ 35 ]. DPH being hydrophobic readily accommodates the hydrocarbon part of the phospholipid bilayer.…”

Section: Discussionmentioning

confidence: 99%

Ellagic acid modulates cisplatin toxicity in DMH induced colorectal cancer: Studies on membrane alterations

Goyal

Koul

Ranawat

2022

Biochemistry and Biophysics Reports

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“…As a result of the therapy, LC cells underwent activation of apoptosis and cell cycle arrest (Qurishi et al 2012 ). According to recent studies, the AKBA may improve membrane fluidity and accompanying lipid content in benzo(a)pyrene-induced lung carcinogenesis (Bhardwaj et al 2019 ), as well as increase the sensitivity of non-small cell LC cells to cisplatin by arresting the cell cycle, inducing apoptosis, and suppressing autophagy via p21-dependent signaling pathway (Lv et al 2021 ). Additionally, novel research found that AKBA improved the sensitivity of radiation-resistant LC cells via controlling the maspin-mediated AKT/FOXO1/p21 pathway (Gong et al 2022 ).…”

Section: Pharmacotherapeutic Actions Of Basmentioning

confidence: 99%

The journey of boswellic acids from synthesis to pharmacological activities

Ragab,

Abd El-Wahab,

Doghish

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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There has been a lot of interest in using naturally occurring substances to treat a wide variety of chronic disorders in recent years. From the gum resin of Boswellia serrata and Boswellia carteri, the pentacyclic triterpene molecules known as boswellic acid (BA) are extracted. We aimed to provide a detailed overview of the origins, chemistry, synthetic derivatives, pharmacokinetic, and biological activity of numerous Boswellia species and their derivatives. The literature searched for reports of B. serrata and isolated BAs having anti-cancer, anti-microbial, anti-inflammatory, anti-arthritic, hypolipidemic, immunomodulatory, anti-diabetic, hepatoprotective, anti-asthmatic, and clastogenic activities. Our results revealed that the cytotoxic and anticancer effects of B. serrata refer to its triterpenoid component, including BAs. Three-O-acetyl-11-keto—BA was the most promising cytotoxic molecule among tested substances. Activation of caspases, upregulation of Bax expression, downregulation of nuclear factor-kappa B (NF-kB), and stimulation of poly (ADP)-ribose polymerase (PARP) cleavage are the primary mechanisms responsible for cytotoxic and antitumor effects. Evidence suggests that BAs have shown promise in combating a wide range of debilitating disease conditions, including cancer, hepatic, inflammatory, and neurological disorders. Graphical abstract

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Acetyl-11-keto-β-boswellic acid modulates membrane dynamics in benzo(a)pyrene-induced lung carcinogenesis

Cited by 11 publications

References 42 publications

Acetyl-11-Keto-β-Boswellic Acid (AKBA) Prevents Lipopolysaccharide-Induced Inflammation and Cytotoxicity on H9C2 Cells

Acetyl-11-Keto-β-Boswellic Acid (AKBA) Prevents Lipopolysaccharide-Induced Inflammation and Cytotoxicity on H9C2 Cells

Ellagic acid modulates cisplatin toxicity in DMH induced colorectal cancer: Studies on membrane alterations

The journey of boswellic acids from synthesis to pharmacological activities

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