Acetate supplementation produces antidepressant-like effect via enhanced histone acetylation

Huang, Wanzhi; Hu, Wenming; Cai, Li-Li; Zeng, Gaofeng; Fang, Wenting; Dai, Xiaoman; Ye, Qinyong; Chen, Xiaochun; Zhang, Jing

doi:10.1016/j.jad.2020.11.121

Cited by 36 publications

(41 citation statements)

References 50 publications

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“… 26 Furthermore, data have shown that antidepressant treatments may improve energy metabolism in depression. 27 , 28 Based on these reasons, baseline LDH, as an indicator of cellular damage and energy metabolism in ischemic stroke, could potentially predict the risk of PSD at discharge. Moreover, acute stroke may be related to the complications of heart and kidney damage, which may increase the levels of LDH and mental stress.…”

Section: Discussionmentioning

confidence: 99%

Higher Serum Lactic Dehydrogenase is Associated with Post-Stroke Depression at Discharge

Li¹,

Miao²,

Pan³

et al. 2021

CIA

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Purpose: Post-stroke depression (PSD) is one of the most common and severe psychological sequelae after stroke, negatively affecting the patient's functional outcome and quality of life. Rapidly measurable biomarkers to predict PSD are pivotal for the optimized care and allocation of healthcare resources. Lactic dehydrogenase (LDH) levels are increased in patients with central nervous system (CNS) disorders such as cerebral infarction and hypoxic-ischemic encephalopathy, which may be related to the occurrence of PSD in acute ischemic stroke (AIS) patients. This study aimed to investigate whether LDH levels on admission are associated with PSD at discharge. Patients and Methods: A multicenter prospective cohort study was conducted, including all consecutive AIS patients within 7 days after symptom onset from May 2018 to October 2019. According to the distribution of LDH and the number of patients, patients were divided into equal tertiles. PSD was evaluated by DSM-V criteria and the 17-item Hamilton Rating Scale for Depression (HRSD-17) at discharge. Results: A total of 518 AIS patients were included. The optimal cut-off points of LDH were: lowest tertile (T1) 102-159/L, middle tertile (T2) 160-189 U/L, and upper tertile (T3) 190-520 U/L. A total of 249 patients (48.07%) were diagnosed with PSD at discharge. After adjusting for potential confounding factors, the odds ratio of T3 PSD was 1.698 (95% CI, 1.070-2.694, P=0.025), compared with T1. Conclusion: In summary, LDH serum levels on admission are associated with PSD at discharge. Clinicians should pay more attention to the baseline LDH level in screening for PSD at discharge.

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Section: Discussionmentioning

confidence: 99%

Higher Serum Lactic Dehydrogenase is Associated with Post-Stroke Depression at Discharge

Li¹,

Miao²,

Pan³

et al. 2021

CIA

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“…Sucrose preference was performed as a measurement of the anhedonia-like behaviors in the mice using the previously reported method [ 31 ]. The animals were caged individually and supplied with two 50 mL conical tubes with spouted rubber tops filled with drink water overnight for habituation.…”

Section: Methodsmentioning

confidence: 99%

“…The FST was conducted according to previous protocols [ 31 ]. Each mouse was individually placed for six minutes into a 19 cm × 25 cm (diameter × height) plastic cylinder filled with water (at 23–25 °C, 18 cm deep) in dim light.…”

Section: Methodsmentioning

confidence: 99%

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Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain

Zeng

Liu

et al. 2022

Nutrients

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Although early life stress (ELS) can increase susceptibility to adulthood psychiatric disorders and produce a greater inflammatory response in a stressful event, targeted preventive and therapeutic drugs still remain scarce. Ganoderma lucidum triterpenoids (GLTs) can exert anti-inflammatory effects in the periphery and central nervous systems. This study employed a combined model of “childhood maternal separation + adulthood sub-stress” to explore whether GLTs may alleviate anxiety- and depression-like behaviors in male and female mice by mitigating inflammation. Male and female pups were separated from their mothers for four hours per day from postnatal day 1 (PND 1) to PND 21; starting from PND 56, GLTs were administered intraperitoneally once daily for three weeks and followed by three days of sub-stress. Results showed that maternal separation increased the anxiety- and depression-like behaviors in both male and female mice, which disappeared after the preemptive GLTs treatment (40 mg/kg) before adulthood sub-stress. Maternal separation up-regulated the pro-inflammatory markers in the periphery and brain, and activated microglia in the prefrontal cortex and hippocampus. All the abnormalities were reversed by GLTs administration, with no adverse effects on immune organ indices, liver, and renal function. Our findings suggest that GLTs can be a promising candidate in treating ELS-induced psychiatric disorders.

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“…For its part, acetate supplementation in mice promotes antidepressant-like effects also at epigenetic levels by increasing histone acetylation with consequent down-regulation of BDNF, enhanced dendritic branches, and spine density of hippocampal pyramidal neurons, hence improving synaptic plasticity in the hippocampus [246]. Similarly, daily vinegar (acetic acid) ingestion was clinically tested in healthy adults, showing improvements in depression scores and amino acids metabolisms (increased metabolism of glycine, serine, threonine) [247].…”

Section: Supplementation With Scfas and Derivativesmentioning

confidence: 99%

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

et al. 2022

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The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning of the organism, affecting the health and disease status of the individuals. There is continuous and bidirectional communication between gut microbiota and the host, conforming to a unique entity known as “holobiont”. Among these crosstalk mechanisms, the gut microbiota synthesizes a broad spectrum of bioactive compounds or metabolites which exert pleiotropic effects on the human organism. Many of these microbial metabolites can cross the blood–brain barrier (BBB) or have significant effects on the brain, playing a key role in the so-called microbiota-gut-brain axis. An altered Microbiota-Gut-Brain (MGB) axis is a major characteristic of many neuropsychiatric disorders, including major depressive disorder (MDD). Significative differences between gut eubiosis and dysbiosis in mental disorders like MDD with their different metabolite composition and concentrations are being discussed. In the present review, the main microbial metabolites (short-chain fatty acids -SCFAs-, bile acids, amino acids, tryptophan -trp- derivatives, and more), their signaling pathways and functions will be summarized to explain part of MDD pathophysiology. Conclusions from promising translational approaches related to microbial metabolome will be addressed in more depth to discuss their possible clinical value in the management of MDD patients.

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Acetate supplementation produces antidepressant-like effect via enhanced histone acetylation

Cited by 36 publications

References 50 publications

Higher Serum Lactic Dehydrogenase is Associated with Post-Stroke Depression at Discharge

Higher Serum Lactic Dehydrogenase is Associated with Post-Stroke Depression at Discharge

Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

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