Acetate Metabolism in Normal Human Subjects

Richards, R H; Vreman, Hendrik J.; Zager, Philip G.; Feldman, Charles; Blaschke, Terrence F.; Weiner, Michael W.

doi:10.1016/s0272-6386(82)80043-7

Cited by 46 publications

(24 citation statements)

References 29 publications

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“…The metabolic rate necessary to off set the bicarbonate losses appears to be close to the max imal rate of acetate metabolism in man (300 mmol/h) [10][11][12], and more specifically, in chronically hemodialized patients (250 mmol/h) [5][6][7][8]. Therefore, any factor reducing the maximal rate of acetate metabolism in a given patient will interfere with this process, and prevent the generation of bicarbonate at a speed sufficient to maintain plasma bicarbonate near 20 mM.…”

Section: Plasma Acetate and Bicarbonate Concentration During Dialysismentioning

confidence: 63%

“…3). Figure 3 was drawn from data obtained in these three studies [10][11][12] and demonstrates that the rate of acetate utilization increases with plasma acetate concentration until a maximal value is observed at blood acetate concentration above 2-3 mM. This maximal value is obtained when the acetate infusion equals 300 mmol/h.…”

Section: Normal Manmentioning

confidence: 95%

“…Acetate metabolism in normal man was studied as a function of plasma acetate concentration using three types of techniques: (1) by following acetate turnover after administration of ethanol (acetate is an obligatory intermediate in this process [11]): (2) by measuring the plasma plateau concentration of acetate during infusion protocols [ 10] (when plasma acetate is stable, the rate of acetate utilization equals the rate of acetate infusion), and (3) by following the disappearance of l4C acetate infused in trace amounts in normal subjects [12]. Clear ly, the data obtained with ethanol may not measure the maximal rate of acetate metabolism since ethanol itself is simultaneously metabolized, and since this may re duce the maximal rate of acetate utilization (see below).…”

Section: Normal Manmentioning

confidence: 99%

“…its metabo lism will proceed according to 0-order kinetics [26,27] (independently of plasma concentration) until the plasma concentration falls below 2 itlV/. and a first-order kinetics occurs [10].…”

Section: Normal Manmentioning

confidence: 99%

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Acetate Metabolism during Hemodialysis: Metabolic Considerations

et al. 1987

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Acetate is used during regular hemodialysis to replace the bicarbonate lost during dialysis. The temporal changes of plasma bicarbonate and acetate concentrations and the critical role of acetate metabolism for the maintenance of plasma bicarbonate are described. We point out that the maximal rate of acetate oxidation in man is usually reached during dialysis, and we identify physiologic and pathologic factors that may modify this V_max. A syndrome of ‘intolerance to acetate’ has been described. This syndrome is analyzed in the light of the metabolic consequences of a rapid flux of acetate oxidation in liver and muscle cells. More specifically, the effects of rapid acetate metabolism on tissue ATP, CoA, adenosine and other ATP degradation products are presented. The possible impact of dialysis-induced depletion of carnitine on optimal acetate metabolism is discussed. The potential clinical consequences produced by these changes are presented in relation to the symptoms sometimes observed during dialysis against acetate: vasodilation, hypotension and angina pectoris. The hypoxemia induced by acetate is also briefly reviewed. Different directions are proposed for future research.

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Section: Plasma Acetate and Bicarbonate Concentration During Dialysismentioning

confidence: 63%

Section: Normal Manmentioning

confidence: 95%

Section: Normal Manmentioning

confidence: 99%

Section: Normal Manmentioning

confidence: 99%

See 2 more Smart Citations

Acetate Metabolism during Hemodialysis: Metabolic Considerations

et al. 1987

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“…To our knowledge the consequences of ingestion of large amounts of acetic acid have not been described in detail. Acetate is rapidly metabolized to bicarbonate in the liver [1]. Therefore, the net effect of acetic acid ingestion on acid base balance shoud be zero.…”

Section: Introductionmentioning

confidence: 99%

Hypokalemia, Hyperreninemia and Osteoporosis in a Patient Ingesting Large Amounts of Cider Vinegar

Lhotta

Höfle

Gasser

et al. 1998

Nephron

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Colorimetric Receptors for the Detection of Biologically Important Anions and Their Application in Designing Molecular Logic Gate

et al. 2020

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Three new colorimetric receptors were synthesised for the detection of biologically important anions such as fluoride and acetate in the aqueous medium. All receptors showed significant colour change for F À and AcO À ions. The synthesised receptors were characterized by spectroscopic methods such as NMR techniques for structural confirmation. The UV-vis and 1 H NMR titrations were performed to understand the binding mechanism of the receptors with F À and AcO À ions. Further, Job's plot was used to explore the stoichiometry between receptor and analyte. Besides, the visual and spectroscopic changes of receptor R1 upon the addition of F À ion was utilised to study the reversible behaviour by adding Cr 3 + ions. This concept was explored to mimic the logic gates at the molecular level with "set-reset" Boolean operations as a proof of concept.

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Acetate Metabolism in Normal Human Subjects

Cited by 46 publications

References 29 publications

Acetate Metabolism during Hemodialysis: Metabolic Considerations

Acetate Metabolism during Hemodialysis: Metabolic Considerations

Hypokalemia, Hyperreninemia and Osteoporosis in a Patient Ingesting Large Amounts of Cider Vinegar

Colorimetric Receptors for the Detection of Biologically Important Anions and Their Application in Designing Molecular Logic Gate

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