Acetaminophen poisoning-induced heart injury: a case-based review

Acute Renal Failure and Hemolytic Uremic Syndrome in Overdose With N-acetyl Cysteine After Acetaminophen Poisoning

“…The interaction between acetaminophen and acetylcysteine in patient survival is more than intoxication with either alone (10). In most previous studies, patients went to the hospital late, and this led to increasing acetaminophen absorption of paracetamol (1,3,7). This increased the interaction of acetaminophen and acetylcysteine, which increased the risk of hepatotoxicity and death in patients (10).…”

“…Taking acetylcysteine orally and intravenously is associated with side effects. Adverse side effects associated with intravenous administration include flushing, rash, nausea, vomiting, and itching, besides tachycardia, bronchospasm, and hypotension in severe cases (1,3). They occur in the first two hours after infusion in 15% of patients (3,11).…”

“…Acetaminophen is one of the most commonly used drugs for suicide attempts in the world (1). There are several medications available as an antidote to acetaminophen (2).…”

Transient Arrhythmia in a Patient With Human Granulocytic Anaplasmosis: An Uncanny Presentation

“…One can argue that acetaminophen could be the potential cause, but its serum level was only slightly above the upper limit of normal. Acetaminophen has been reported to be associated with myocardial injury [ 9 - 10 ], causing dysrhythmias as a result. The postulated mechanisms of injury have been reported to be multifaceted, including metabolic disturbances, hypoxia, increased levels of free fatty acids, catecholamines, and hypotension.…”

“…All have been secondary to hepatic failure as well as direct toxic effects like oxidative stress and structural changes in protein and gene derangements. All the reported cases failed to establish a causal relationship between cardiotoxicity and acetaminophen toxicity convincingly and stood out as mere associations [ 10 ]. However, the normal range of troponin in our patient will argue against acetaminophen, causing myocardial injury and, in turn, causing atrial fibrillation.…”