“…As well, NAPQI has potent agonist effect on ankyrin 1 receptor (Gentry et al, 2015). Remarkably, both acetaminophen and its metabolites stimulate TRPV1 in the inhibitory pain pathway leading to analgesic effects at supraspinal level (Irinmwinuwa et al, 2022). In addition, TRPV4 which is highly expressed in the CNS is involved in the activation of dorsal root ganglion, neuronal hyperexcitability, hyperalgesia and the development of neuropathic pain (Qu et al, 2016).…”