Acetaldehyde self-administration by a two-bottle choice paradigm: Consequences on emotional reactivity, spatial learning, and memory

Plescia, Fulvio; Brancato, Anna; Vènniro, Marco; Maniaci, Giuseppe; Cannizzaro, Emanuele; Sutera, Flavia Maria; De, Viviana; Giannola, Libero Italo; Cannizzaro, Carla

doi:10.1016/j.alcohol.2015.01.002

Cited by 31 publications

(29 citation statements)

References 66 publications

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“…Given the marked ontogenetic changes concerning peripheral or central EtOH metabolism, it is also difficult to extrapolate what is known in adults to early ontogenetic stages. Considering this important limitation, the adult literature endorses the anxiogenic effects of the metabolite following its ingestion (Plescia et al, 2015) as well as when the metabolite is intraperitoneally administered (Escrig et al, 2012). When ACD peripheral metabolism was inhibited through cyanamide there were no indications that ACD participates in EtOH-induced anxiolytic effects (Tambour et al, 2005).…”

Section: Acetaldehyde Metabolism During Early Ontogeny: Early Motivatmentioning

confidence: 99%

Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies

Miranda-Morales

D'aloisio

Anunziata

et al. 2020

Front. Behav. Neurosci.

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Section: Acetaldehyde Metabolism During Early Ontogeny: Early Motivatmentioning

confidence: 99%

Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies

Miranda-Morales

D'aloisio

Anunziata

et al. 2020

Front. Behav. Neurosci.

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“…In particular, while some studies have described detection of brain acetaldehyde after peripheral ethanol (Kiessling, 1962; Sippel, 1974; Tabakoff et al, 1976; Eriksson and Sippel, 1977; Westcott et al, 1980; Hamby-Mason et al, 1997; Peana et al, 2008, 2010b) or acetaldehyde administration (Heap et al, 1995; Ward et al, 1997; Quertemont et al, 2004; Plescia et al, 2015), others reported failure to detect it after administration of either ethanol (Sippel, 1974; Eriksson and Sippel, 1977; Jamal et al, 2007) or acetaldehyde itself (Peana et al, 2010a). Indeed, increases of acetate but not acetaldehyde were detected in human plasma after ethanol intake (Puig and Fox, 1984; Sarkola et al, 2002).…”

Section: The Issue Of Acetaldehyde Determinationmentioning

confidence: 99%

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

Peana

Sánchez-Catalán

Hipólito

et al. 2017

Front. Behav. Neurosci.

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After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, looked as they were extensively characterized. However, almost 5 years after this research appeared at its highest momentum, the investigations on this topic have been revitalized on at least three main directions: (1) the role and the behavioral significance of acetaldehyde in different phases of ethanol self-administration and in voluntary ethanol consumption; (2) the distinction, in the central effects of ethanol, between those arising from its non-metabolized fraction and those attributable to ethanol-derived acetaldehyde; and (3) the role of the acetaldehyde-dopamine condensation product, salsolinol. The present review article aims at presenting and discussing prospectively the most recent data accumulated following these three research pathways on this never-ending story in order to offer the most up-to-date synoptic critical view on such still unresolved and exciting topic.

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“…Specific animal models, in which dams are provided with limited nesting resources in an unfamiliar environment, could be employed. In addition, active metabolites, such as acetaldehyde, by the formation of condensation products with dopamine and serotonin, such as salsolinol and other alkaloids, may act in the brain as main players of alcohol-and tobacco-reinforcing properties (Cannizzaro et al, 2010;Cacace et al, 2012b;Plescia et al, 2013Plescia et al, , 2014bPlescia et al, , 2015aBrancato et al, 2014Brancato et al, , 2017. In this regard, the elucidation of their effects on mother-infant interaction and the developing brain are still lacking.…”

Section: Future Directionsmentioning

confidence: 99%

Mothering under the influence: how perinatal drugs of abuse alter the mother-infant interaction

Brancato

Cannizzaro

2018

Reviews in the Neurosciences

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AbstractAlthough drug-abusing women try to moderate their drug and alcohol use during pregnancy, they often relapse at a time when childcare needs are high and maternal bonding is critical to an infant’s development. In the clinical setting, the search for the neural basis of drug-induced caregiving deficits is complex due to several intervening variables. Rather, the preclinical studies that control for drug dose and regimen, as well as for gestational and postpartum environment, allow a precise determination of the effects of drugs on maternal behaviour. Given the relevance of the issue, this review will gather reports on the phenotypic correlates of maternal behaviour in preclinical studies, and focus on the detrimental consequences on the mother-infant interaction exerted by the perinatal use of alcohol, nicotine, cannabis, cocaine and stimulants and opiates. The drug-induced disruptions of this maternal repertoire are associated with adverse maternal and infant outcomes. A comprehensive overview will help promote the refinement of the treatment approaches toward maternal drug use disorders and maternal misbehaviour, in favour of augmented parenting resiliency.

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Acetaldehyde self-administration by a two-bottle choice paradigm: Consequences on emotional reactivity, spatial learning, and memory

Cited by 31 publications

References 66 publications

Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies

Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

Mothering under the influence: how perinatal drugs of abuse alter the mother-infant interaction

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