“…In particular, while some studies have described detection of brain acetaldehyde after peripheral ethanol (Kiessling, 1962; Sippel, 1974; Tabakoff et al, 1976; Eriksson and Sippel, 1977; Westcott et al, 1980; Hamby-Mason et al, 1997; Peana et al, 2008, 2010b) or acetaldehyde administration (Heap et al, 1995; Ward et al, 1997; Quertemont et al, 2004; Plescia et al, 2015), others reported failure to detect it after administration of either ethanol (Sippel, 1974; Eriksson and Sippel, 1977; Jamal et al, 2007) or acetaldehyde itself (Peana et al, 2010a). Indeed, increases of acetate but not acetaldehyde were detected in human plasma after ethanol intake (Puig and Fox, 1984; Sarkola et al, 2002).…”