Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies

Miranda-Morales, Roberto Sebastián; D'aloisio, Génesis; Anunziata, Florencia; Abate, Paula; Molina, Juan Carlos

doi:10.3389/fnbeh.2020.00033

Cited by 9 publications

(5 citation statements)

References 189 publications

(210 reference statements)

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“…Gestational acetaldehyde did appear to mediate subsequent ethanol intake on the second day of assessment when using an artificial lactation test (Figure 4C). Those pups prenatally exposed to a moderate ethanol dose showed a higher %BWG and absolute ethanol intake than controls (Figures 4A,B) as also reported in the short-and long-term (Domínguez et al, 1998;Pueta et al, 2008;Díaz-Cenzano and Chotro, 2010;Fabio et al, 2013Fabio et al, , 2015; an event recently proposed as fetal early programming of subsequent ethanol affinity (Miranda-Morales et al, 2020). Along with a heightened ethanol intake, pups showed an overall increase in milk consumption -a natural reinforcer- (Bachmanov et al, 2003;Pueta et al, 2008).…”

Section: Discussionsupporting

confidence: 75%

“…Beyond ethanol’s teratogenic effects, early brief experiences (e.g., gestational days, GDs 17–20) with low-to-moderate doses of the drug (e.g., sub-teratogenic, 0.5–2.0 g/kg) recruit sensory, perceptual, and learning capabilities of the organisms that result in the recognition of its chemosensory attributes, sensitivity to its motivational properties, and the subsequent drug seeking and consumption ( Chotro et al, 2007 ; Molina et al, 2007 ; Abate et al, 2008 ). The process has been recently proposed as an early programming of alcohol affinity ( Miranda-Morales et al, 2020 ). The late gestation and the first week of the rat are stages analogous to the second and third gestational human trimester in terms of brain growth ( Dobbing and Sands, 1979 ; Tran et al, 2000 ; Almeida et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Moderate ethanol exposure during early ontogeny of the rat alters respiratory plasticity, ultrasonic distress vocalizations, increases brain catalase activity, and acetaldehyde-mediated ethanol intake

D'aloisio

Acevedo²,

Angulo-Alcalde³

et al. 2022

Front. Behav. Neurosci.

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Early ontogeny of the rat (late gestation and postnatal first week) is a sensitive period to ethanol’s positive reinforcing effects and its detrimental effects on respiratory plasticity. Recent studies show that acetaldehyde, the first ethanol metabolite, plays a key role in the modulation of ethanol motivational effects. Ethanol brain metabolization into acetaldehyde via the catalase system appears critical in modulating ethanol positive reinforcing consequences. Catalase system activity peak levels occur early in the ontogeny. Yet, the role of ethanol-derived acetaldehyde during the late gestational period on respiration response, ultrasonic vocalizations (USVs), and ethanol intake during the first week of the rat remains poorly explored. In the present study, pregnant rats were given a subcutaneous injection of an acetaldehyde-sequestering agent (D-penicillamine, 50 mg/kg) or saline (0.9% NaCl), 30 min prior to an intragastric administration of ethanol (2.0 g/kg) or water (vehicle) on gestational days 17–20. Respiration rates (breaths/min) and apneic episodes in a whole-body plethysmograph were registered on postnatal days (PDs) 2 and 4, while simultaneously pups received milk or ethanol infusions for 40-min in an artificial lactation test. Each intake test was followed by a 5-min long USVs emission record. On PD 8, immediately after pups completed a 15-min ethanol intake test, brain samples were collected and kept frozen for catalase activity determination. Results indicated that a moderate experience with ethanol during the late gestational period disrupted breathing plasticity, increased ethanol intake, as well brain catalase activity. Animals postnatally exposed to ethanol increased their ethanol intake and exerted differential affective reactions on USVs and apneic episodes depending on whether the experience with ethanol occur prenatal or postnatally. Under the present experimental conditions, we failed to observe, a clear role of acetaldehyde mediating ethanol’s effects on respiratory plasticity or affective states, nevertheless gestational acetaldehyde was of crucial importance in determining subsequent ethanol intake affinity. As a whole, results emphasize the importance of considering the participation of acetaldehyde in fetal programming processes derived from a brief moderate ethanol experience early in development, which in turn, argues against “safe or harmless” ethanol levels of exposure.

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Moderate ethanol exposure during early ontogeny of the rat alters respiratory plasticity, ultrasonic distress vocalizations, increases brain catalase activity, and acetaldehyde-mediated ethanol intake

D'aloisio

Acevedo²,

Angulo-Alcalde³

et al. 2022

Front. Behav. Neurosci.

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“…Early perceptual abilities may indeed be either tuned to detect a configuration of multiple compounds conveying a given aroma gestalt or odor signature to milk, or they may be specialized to detect one compound or a small subset of compounds in milk. The first option relies on the attractive potency of colostrum as a by‐product of the fetuses' experience of amniotic fluid odor, the environment that shapes the operational properties of early olfaction (eg, Miranda‐Morales, D'Aloisio, Anunziata, Abate, & Molina, 2020; Schaal et al, 1998, 2000; Smotherman & Robinson, 1985; Todrank, Heth, & Restrepo, 2011). Neonates' attraction to colostrum relative to later‐lactation milk could therefore originate from the greater resemblance of colostrum's odor profile with the one of amniotic odor (Schaal, 2016).…”

Section: Discussionmentioning

confidence: 99%

Human neonates prefer colostrum to mature milk: Evidence for an olfactory bias toward the “initial milk”?

Klaey-Tassone

Durand

Damon

et al. 2020

American J Hum Biol

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Objectives Colostrum is the initial milk secretion which ingestion by neonates warrants their adaptive start in life. Colostrum is accordingly expected to be attractive to newborns. The present study aims to assess whether colostrum is olfactorily attractive for 2‐day‐old newborns when presented against mature milk or a control. Methods The head‐orientation of waking newborns was videotaped in three experiments pairing the odors of: (a) colostrum (sampled on postpartum day 2, not from own mother) and mature milk (sampled on average on postpartum day 32, not from own mother) (n tested newborns = 15); (b) Colostrum and control (water; n = 9); and (c) Mature milk and control (n = 13). Results When facing the odors of colostrum and mature milk, the infants turned their nose significantly longer toward former (32.8 vs 17.7% of a 120‐s test). When exposed to colostrum against the control, they responded in favor of colostrum (32.9 vs 16.6%). Finally, when the odor of mature milk was presented against the control, their response appeared undifferentiated (26.7 vs 28.6%). Conclusions These results indicate that human newborns can olfactorily differentiate conspecific lacteal fluids sampled at different lactation stages. They prefer the odor of the mammary secretion ‐ colostrum ‐ collected at the lactation stage that best matches the postpartum age of their own mother. These results are discussed in the context of the earliest mother‐infant chemo‐communication. Coinciding maternal emission and offspring reception of chemosignals conveyed in colostrum may be part of the sensory precursors of attunement between mothers and infants.

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“…5 E n e l S e r v i c i o d e N e o n a t o l o g í a d e l Hospital Misericordia, junto con un grupo de investigadores del Instituto de Investigación M é d i c a M e r c e d e s y M a r t í n F e r r e y r a , s e desarrolló un estudio clínico sobre los diversos efectos fisiológicos de la exposición a dosis no teratogénicas de alcohol durante la gestación, 6 en continuidad con una serie de experimentos preclínicos realizados sobre el tema. 7 En este estudio, se establecieron, a través de entrevistas exhaustivas, 3 categorías de EPA: sin consumo o infrecuente, moderado, excesivo y/o binge. Los neonatos fueron estimulados con el aroma de escasas cantidades de alcohol y con el Comentarios aroma a limón (olor nuevo), mientras eran evaluados en términos de respuestas fisiológicas y comportamentales.…”

Section: Alcohol Consumption During Pregnancyunclassified

Consumo de alcohol durante el embarazo

2021

Arch Argent Pediat

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Fetal Alcohol Programming of Subsequent Alcohol Affinity: A Review Based on Preclinical, Clinical and Epidemiological Studies

Cited by 9 publications

References 189 publications

Moderate ethanol exposure during early ontogeny of the rat alters respiratory plasticity, ultrasonic distress vocalizations, increases brain catalase activity, and acetaldehyde-mediated ethanol intake

Moderate ethanol exposure during early ontogeny of the rat alters respiratory plasticity, ultrasonic distress vocalizations, increases brain catalase activity, and acetaldehyde-mediated ethanol intake

Human neonates prefer colostrum to mature milk: Evidence for an olfactory bias toward the “initial milk”?

Consumo de alcohol durante el embarazo

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