Acellular pertussis vaccine use in risk groups (adolescents, pregnant women, newborns and health care workers): A review of evidences and recommendations

Vaccination of healthcare workers: A review

“…158 Benefits and risks in healthcare settings Pertussis outbreaks in nosocomial settings are well-described in many countries with more than 30 reported nosocomial outbreaks. [160][161][162] The index cases were often found among healthcare staff, and B. pertussis transmission occurred more frequently among colleagues than between HCWs and their patients. [160][161][162] HCWs and patients may serve as pertussis sources in nosocomial outbreaks, which can result in substantial morbidity and constrain infection control measures.…”

“…[160][161][162] The index cases were often found among healthcare staff, and B. pertussis transmission occurred more frequently among colleagues than between HCWs and their patients. [160][161][162] HCWs and patients may serve as pertussis sources in nosocomial outbreaks, which can result in substantial morbidity and constrain infection control measures. [160][161][162] Pertussis HCW immunization, testing and limitation of patient contact in case of prolonged cough could reduce the morbidity of pertussis outbreaks.…”

“…[160][161][162] HCWs and patients may serve as pertussis sources in nosocomial outbreaks, which can result in substantial morbidity and constrain infection control measures. [160][161][162] Pertussis HCW immunization, testing and limitation of patient contact in case of prolonged cough could reduce the morbidity of pertussis outbreaks. [160][161][162] Currently, no RCT data support the effectiveness of pertussis vaccination in HCWs to prevent outbreaks and infant morbidity/mortality.…”

“…[160][161][162] Pertussis HCW immunization, testing and limitation of patient contact in case of prolonged cough could reduce the morbidity of pertussis outbreaks. [160][161][162] Currently, no RCT data support the effectiveness of pertussis vaccination in HCWs to prevent outbreaks and infant morbidity/mortality. [160][161][162][163] Furthermore, there are no approved protection correlates for pertussis vaccines.…”

Pertussis

“…However, as reported above, since the early 2000s, the incidence of pertussis has started to return back to previous levels in several geographical areas where vaccine coverage has been high for a long time (e.g., USA, Australia, UK). 69 This return of the disease is to be related to reduced ability of currently used pertussis vaccines to induce long-term protection, especially in areas where natural exposure levels have been low for several years. [70][71][72] Thus, there is the need for identifying an immunization strategy designed to prevent the spreading of the infection in all age groups and, above all, that enables the prevention of the disease in infants, who suffer from the most serious complications of the disease, including death.…”