Efficacy and safety of pertussis vaccination in pregnancy to prevent whooping cough in early infancy

Murthy, Shruti; Godinho, Myron Anthony; Lakiang, Theophilus; Lewis, Melissa Glenda; Lewis, Leslie; Nair, N. Sreekumaran

doi:10.1002/14651858.cd013008

Cited by 4 publications

(14 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27 This strategy has been proven useful before in whooping cough, as its mortality has decreased greatly since the start of vaccination of pregnant women. 28,29 Thus, we could also have positive results against RSV bronchiolitis by applying the inactivated vaccine during the pregnancy. 30 Vaccination of children at a very young age could be another strategy to evaluate, along with the particular seasonal characteristics of RSV and the complexity of implementing a new vaccine into the current routine vaccination schedules.…”

Section: Discussionmentioning

confidence: 99%

Burden of severe bronchiolitis in children up to 2 years of age in Spain from 2012 to 2017

Montero

Gil-Prieto

Walter

et al. 2021

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Bronchiolitis represents a heavy burden of disease in children under 2 years of age in our society due to the high infectivity of the Respiratory Syncytial Virus [RSV] and the vulnerability of the youngest children. The objective of this retrospective epidemiological study was to show the burden of severe bronchiolitis in Spain through population-based estimates of hospitalizations due to bronchiolitis in children up to 24 months old during a 6-year period (2012)(2013)(2014)(2015)(2016)(2017). A total of 100,115 cases of bronchiolitis required hospitalization in Spain from 2012 to 2017. Most cases of bronchiolitis that required hospitalization were in infants under 3 months of age. The hospitalization rate for bronchiolitis for children under 1 year of age was 3,838.27 per 100,000 healthy children. During the 6-year study period, a total of 82 deaths due to bronchiolitis were reported among hospitalized infants. Among these deaths, more than 50% were in patients younger than 3 months of age. The annual average cost to the National Health Care System was €58 M, with a mean hospitalization cost of €3,512 per case.

show abstract

Section: Discussionmentioning

confidence: 99%

Burden of severe bronchiolitis in children up to 2 years of age in Spain from 2012 to 2017

Montero

Gil-Prieto

Walter

et al. 2021

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

show abstract

“…Clinically, the milder catarrhal phase manifests itself as flu-like, nonspecific symptoms: cough, runny nose, mild fever, which, regrettably, makes early diagnosis difficult. Conversely, a severe course, called the paroxysmal phase is more specific (an audible inspiratory whoop followed by paroxysmal cough and vomiting) [1,2]. Early antibiotic therapy may alleviate symptoms (when implemented before the onset of the paroxysmal stage).…”

Section: Introductionmentioning

confidence: 99%

“…It should be noted that vaccination is the most cost-effective form of preventing whooping cough epidemics [2].…”

Section: Introductionmentioning

confidence: 99%

Pertussis vaccination in pregnancy — current data on safety and effectiveness

2021

View full text Add to dashboard Cite

show abstract

“…In most Asian countries including India [ 10 , 11 ], Korea [ 12 ] and the Philippines [ 13 ], pertussis is a notifiable disease. However, due to the limited data on neonatal disease burden and the lack of a well-established disease surveillance system, pertussis is not considered an important public health issue, especially by local healthcare professionals (HCPs).…”

Section: Introductionmentioning

confidence: 99%

“…The HCPs seldom suspect pertussis because of the non-specificity of symptoms, lack of awareness and non-availability of diagnostic facilities. Together, these factors contribute to gross under-reporting, which leads to an under-representation of the true disease burden [ 10 , 11 ]. Data on the neonatal pertussis disease burden across various South and Southeast Asian countries will guide HCPs in making informed decisions about pertussis vaccination to protect newborns.…”

Section: Introductionmentioning

confidence: 99%

Neonatal Pertussis, an Under-Recognized Health Burden and Rationale for Maternal Immunization: A Systematic Review of South and South-East Asian Countries

et al. 2019

View full text Add to dashboard Cite

Pertussis is an under-recognized cause of neonatal morbidity and mortality. To review information on the epidemiology and disease burden of neonatal pertussis in South and Southeast Asian countries, a systematic literature review of three bibliographic databases was undertaken. Peer-reviewed original studies on neonatal pertussis epidemiology and burden published since 2000, with a geographical scope limited to South and Southeast Asian countries, were included. Data were systematically extracted based on parameters defined a priori. Our findings show that the burden of neonatal pertussis and its complications is substantial. An increase in the number of pertussis cases has been noted since early 2000, ranging from 61 to 92.9% in infants 0–3 months old. The most common symptoms an infant is likely to present with are cough with or without paroxysms, cyanosis, apnea, tachypnea, difficulty in breathing and leukocytosis. In addition, it can lead to hospitalization (length of stay: 5–7 days), complications (e.g., pneumonia, seizures) and mortality ranging from 5.6 to 14.7%. Other observations indicate that diagnosis is challenging because of non-specific clinical symptoms. Specifically, for obstetricians and gynecologists, the information available for making informed decisions on the prevention of neonatal pertussis is unreliable. Maternal immunization against pertussis during late stages of pregnancy has proven to be efficacious and well tolerated. A high burden of neonatal pertussis, as well as its complications, is observed in South and Southeast Asian countries. There is a need to intensify efforts to protect this vulnerable population with maternal vaccination. Funding : GlaxoSmithKline Biologicals SA Plain Language Summary : Plain language summary available for this article. Please see Fig. 1 and the following link: https://doi.org/10.6084/m9.figshare.7951187 .

show abstract

Efficacy and safety of pertussis vaccination in pregnancy to prevent whooping cough in early infancy

Cited by 4 publications

References 40 publications

Burden of severe bronchiolitis in children up to 2 years of age in Spain from 2012 to 2017

Burden of severe bronchiolitis in children up to 2 years of age in Spain from 2012 to 2017

Pertussis vaccination in pregnancy — current data on safety and effectiveness

Neonatal Pertussis, an Under-Recognized Health Burden and Rationale for Maternal Immunization: A Systematic Review of South and South-East Asian Countries

Contact Info

Product

Resources

About