Acebutolol-Induced Decrease of Mononuclear Leukocyte &amp;beta;-Adrenoceptors in Hypertension

Basso, Andrea; Piantanelli, L.; Cognini, G.; Giunta, Salvatore; Andreoni, A.; Paciaroni, E

doi:10.1159/000138132

Cited by 11 publications

(2 citation statements)

References 12 publications

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“…There is evidence that treatment with beta blockers with ISA is associated with downregulation of beta-2 receptors 48. This is consistent with data from an analysis that shows that continued treatment with beta-1 blockers with ISA did not produce the increase in beta-2 agonist response that was seen with beta-1 blockers without ISA 49…”

Section: Beta Blockers With Intrinsic Sympathomimetic Activity (Isa)supporting

confidence: 75%

Current perspectives on treatment of hypertensive patients with chronic obstructive pulmonary disease

Chandy

Aronow²,

Banach³

2013

IBPC

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Systemic hypertension and chronic obstructive pulmonary disease (COPD) frequently coexist in the same patient, especially in the elderly. Today, a wide variety of antihypertensive drugs with different mechanisms of action are available to the prescribing physician. In addition, combination drugs for hypertension are becoming increasingly popular. Certain antihypertensive drugs can affect pulmonary function. Therefore the management of such patients can present therapeutic challenges. We have examined the literature pertaining to the use of antihypertensive drugs in patients with systemic hypertension and coexisting COPD. Although data are often limited or of poor quality, we have attempted to review and then provide recommendations regarding the use of all the specific classes of antihypertensive drug therapies including combination drugs in patients with COPD. The antihypertensive agents reviewed include diuretics, aldosterone receptor blockers, beta blockers, combined alpha and beta blockers, angiotensin-converting enzyme inhibitors, angiotensin II antagonists, calcium channel blockers, alpha-1 blockers, centrally acting drugs, direct vasodilators, and combinations of these drugs. Of these classes, calcium channel blockers and angiotensin II antagonists appear to be the best initial choices if hypertension is the only indication for treatment. However, the limited data available on many of these drugs suggest that additional studies are needed to more precisely determine the best treatment choices in this widely prevalent patient group.

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Section: Beta Blockers With Intrinsic Sympathomimetic Activity (Isa)supporting

confidence: 75%

Current perspectives on treatment of hypertensive patients with chronic obstructive pulmonary disease

Chandy

Aronow²,

Banach³

2013

IBPC

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“…-adrenoceptor affinity and density of human mononuclear leukocytes were assayed before and after treatment with ACE. While receptor affinity showed no changes between pre-and posttreatment values, a statistically significant decrease was demonstrated in receptor density following treatment [234]. The density and affinity of -receptors were evaluated before and after indenolol (IND) therapy in membranes of PMNL of patients with essential hypertension.…”

Section: Adrenergic Receptors On Pmnlsmentioning

confidence: 98%

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

Nosáľ¹

2006

CHAMC

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In vitro and ex vivo interactions of betaadrenoceptor blocking drugs, antihistamines and chloroquine with blood platelets and polymorphonuclear leukocytes resulted in different alterations of regulatory functions of these blood cells. Inhibition of platelet aggregation, arachidonate regulatory pathway, 5-hydroxytryptamine transportation, removal of platelet membrane receptors, inhibition of second messenger pathways at subcellular level and suppression of phagocytosis are indicative of nonreceptor rather than specific receptor interactions. Binding of drugs with biomembranes is reversible depending on the ionic charge of the molecule and hydrophobicity of the bilayer, partition coefficient, pH and pKa of the amphiphilic molecules and other physico-chemical properties of amphiphilic drugs. Alterations in the drug molecule structure alters the drug-phospholipid binding profile. Any change in the metabolism of membrane phospholipids directly or indirectly influences one or more of the important components of the phospholipid-signalling pathway. In addition to changes in phospholipase A, C and D activities, protein kinase C, calmodulin-phosphodiesterase, Ca2+,Mg2+-ATPase, Na+,K+-ATPase and other messengers were found to be changed in cells and tissue after cationic amphiphilic drug (CAD) administration. Although not much has been understood of the mechanism by which some CAD affect immune functions, there are good reasons to suggest that these effects might occur. CADs share sufficient similarities in their structure even though they come from diverse pharmacological classes. CADs affect ion transport, immune functions, tumour growth, serotonin metabolism and several other functions in the body. Extensive therapeutic use and associated side effects have generated a great deal of interest in understanding the nonreceptor interactions with CADs.

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Cardioselective beta-blockers for reversible airway disease

Salpeter

Ormiston

Salpeter

et al. 2002

Cochrane Database of Systematic Reviews

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Acebutolol-Induced Decrease of Mononuclear Leukocyte β-Adrenoceptors in Hypertension

Cited by 11 publications

References 12 publications

Current perspectives on treatment of hypertensive patients with chronic obstructive pulmonary disease

Current perspectives on treatment of hypertensive patients with chronic obstructive pulmonary disease

Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs

Cardioselective beta-blockers for reversible airway disease

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