ACE2 suppresses the inflammatory response in LPS-induced porcine intestinal epithelial cells via regulating the NF-κB and MAPK pathways

Li, Zhiqiang; Wang, Kai; Ji, Xiaoxia; Wang, Huanhuan; Zhang, Yuanshu

doi:10.1016/j.peptides.2021.170717

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…The anti-injury effect of ACE2 has become a consensus, and the discovery of its multiple physiological functions has made ACE2 a new disease marker and drug therapeutic target. Our previous studies have also confirmed that the anti-inflammatory effect of ACE2 is mediated by inhibiting the NF-κB and MAPK pathways ( Li et al., 2022 ). ACE2 has been proved to be a functional receptor for SARS-CoV and SARS-CoV-2 ( Li et al., 2003 ; Markus et al., 2020 ), and it also plays an important pathophysiological role in the disease process caused by these viruses.…”

Section: Introductionsupporting

confidence: 55%

Angiotensin converting enzyme 2 does not facilitate porcine epidemic diarrhea virus entry into porcine intestinal epithelial cells and inhibits it-induced inflammatory injury by promoting STAT1 phosphorylation

Li,

Chen,

et al. 2024

Virus Research

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Section: Introductionsupporting

confidence: 55%

Angiotensin converting enzyme 2 does not facilitate porcine epidemic diarrhea virus entry into porcine intestinal epithelial cells and inhibits it-induced inflammatory injury by promoting STAT1 phosphorylation

Li,

Chen,

et al. 2024

Virus Research

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“…38 Studies have shown that overexpression or specific activation of ACE2 can counter the inflammatory response of LPS-induced epithelial cells by inhibiting the activation of the NF-κB pathway. 39,40 In our study, we showed that overexpression of ACE2 countered the activation of the NF-κB pathway caused by Aβ 25-35 , which not only inhibits the increased expression of VEGF but also may reduce…”

Section: Discussionmentioning

confidence: 61%

Overexpression of ACE2 ameliorates Aβ‐induced blood–brain barrier damage and angiogenesis by inhibiting NF‐κB/VEGF/VEGFR2 pathway

Zhang

et al. 2023

Anim Models and Exp Med

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“…In addition, IECs participate in regulating inflammatory responses by producing antimicrobial peptides [ 3 ]. Conversely, some evidence has confirmed that the destruction of the intestinal barrier causes severe tissue damage and microbial invasion [ 4 ]. Therefore, the protection and restoration of the intestinal barrier are critical in preventing the invasion of intestinal microbes into the gut tissue and decreasing the inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of a Novel Probiotic Bifidobacterium pseudolongum on the Intestinal Barrier of Colitis Mice via Modulating the Pparγ/STAT3 Pathway and Intestinal Microbiota

Guo

Mao

Cui

et al. 2022

Foods

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Colitis has become a major health concern worldwide. The objective of the present study was to determine the probiotic influence of different strains of B. pseudolongum (Bp7 and Bp8) on alleviating colitis and to explore its possible potential mechanisms. Our results displayed that Bp7 and Bp8 intervention effectively reduced dextran sodium sulfate (DSS)-caused body weight loss and the release of several pro-inflammatory factors (interleukin (IL)-6, IL-1β, and tumor necrosis factor-α (TNF-α)) and increased the activities of antioxidant enzymes (T-AOC, SOD, and GSH) and the concentrations of tight junction proteins (occludin, claudin-1, and ZO-1). Moreover, Bp7 and Bp8 intervention drastically down-regulated the expression of colonic MyD88, NF-κB, iNOS and COX2 and drastically elevated the expression of colonic STAT3, Nrf2, and PPARγ. Gas chromatography-mass spectrometry results revealed that the cecal levels of isobutyric, butyric, and isovaleric acids were drastically increased in colitis mice intervened with Bp7 and Bp8. Moreover, 16S rRNA sequencing revealed that Bp7 and Bp8 intervention modulated the intestinal microbiota structure, particularly by enhancing the proportion of Eubacterium coprostanoligenes group, Marvinbryantia, Enterorhabdus, Faecalibaculum, Coriobacteriaceae UCG 002, Alistipes, and Bifidobacterium, which are relevant to the levels of cecal isobutyric acid, butyric acid, isovaleric acid, and inflammatory cytokines. Collectively, these findings suggest that Bp7 and Bp8 intervention alleviates the intestinal barrier function, possibly by blocking the secretion of proinflammatory cytokines, maintaining the intestinal physical barrier integrity, activating the PPARγ/STAT3 pathway, and modulating intestinal microbiota composition. Our study also suggested that B. pseudolongum is a promising probiotic for colitis treatment.

show abstract

ACE2 suppresses the inflammatory response in LPS-induced porcine intestinal epithelial cells via regulating the NF-κB and MAPK pathways

Cited by 10 publications

References 22 publications

Angiotensin converting enzyme 2 does not facilitate porcine epidemic diarrhea virus entry into porcine intestinal epithelial cells and inhibits it-induced inflammatory injury by promoting STAT1 phosphorylation

Angiotensin converting enzyme 2 does not facilitate porcine epidemic diarrhea virus entry into porcine intestinal epithelial cells and inhibits it-induced inflammatory injury by promoting STAT1 phosphorylation

Overexpression of ACE2 ameliorates Aβ‐induced blood–brain barrier damage and angiogenesis by inhibiting NF‐κB/VEGF/VEGFR2 pathway

Protective Effects of a Novel Probiotic Bifidobacterium pseudolongum on the Intestinal Barrier of Colitis Mice via Modulating the Pparγ/STAT3 Pathway and Intestinal Microbiota

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