Accurate mass measurement in the absence of calibrant for capillary column gas chromatography/Fourier transform mass spectrometry

Johlman, Carolyn L.; Laude, David A.; Wilkins, Charles L.

doi:10.1021/ac00283a018

Cited by 21 publications

(7 citation statements)

References 17 publications

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“…Obviously for chromatography experiments in which neutral populations vary over several orders of magnitude, neither option is feasible. Successful accurate mass measurement studies reported in previous GC/FTMS work were obtained for mixtures with components of approximately equal concentration (21). Suspended trapping is effective in simplifying mass calibration because the detected ion population is reduced to levels at which the ion Coulombic electric field term is negligible.…”

Section: Resultsmentioning

confidence: 95%

“…Simplified Mass Calibration. FTMS mass measurement accuracy at the lowand sub-ppm error level has been shown in numerous applications (15,(18)(19)(20), including GC/FTMS measurements in which low-ppm errors over a wide mass range in the absence of calibrant ions were demonstrated for simple synthetic mixtures (21)(22)(23). Routine low-ppm errors are possible, however, only when the analyte ion population is well controlled.…”

Section: Resultsmentioning

confidence: 99%

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Suspended trapping procedure for alleviation of space charge effects in gas chromatography/Fourier-transform mass spectrometry

Hogan¹,

Laude²

1990

Anal. Chem.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Suspended trapping procedure for alleviation of space charge effects in gas chromatography/Fourier-transform mass spectrometry

Hogan¹,

Laude²

1990

Anal. Chem.

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“…The development of differentially pumped instruments has overcome this limitation, and in particular, the use of a dual cell design is ideal for GC/FTMS. GC column effluent is introduced directly into the source with helium carrier gas resulting in source pressures in the high 10" 6 torr range and analyzer pressures in the low 10" 8 torr range, which are acceptable for high performance FTMS [12].…”

Section: Gcjftmsmentioning

confidence: 99%

High performance Fourier transform mass spectrometry for chemical analysis / Hochleistungs-Fourier-Massen-Spektrometrie in der chemischen Analytik

Laude¹,

Hogan²

1990

tm - Technisches Messen

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Keywords: Fourier transform mass spectrometry, chemical analysis Schlagwörter: Fourier-Transform-Massenspektrometrie, chemische Analyse Fourier transform mass spectrometry (FTMS) is introduced as an alternative to sector mass analyzers for high performance mass spectrometry. The basic instrumentation and operating principles of a single cell FTMS are first introduced. More elaborate spectrometer configurations that overcome the source/analyzer pressure mismatch are also discussed. Finally, the advantages of FTMS for applications in chemical analysis are represented through specific examples of laser desorptionjionization for high mass measurements and gas chromatography/FTMS for complex mixture analysis.

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“…TOF mass spectrometers are inadequate for such determinations. This problem can be overcome by coupling MALDI to a Fourier transform ion cyclotron resonance mass spectrometer (FTICR-MS)-an established method to achieve ultra high mass resolution and perform accurate mass measurements [11][12][13][14][15][16][17].…”

mentioning

confidence: 99%

High resolution end group determination of low molecular weight polymers by matrix-assisted laser desorption ionization on an external ion source fourier transform ion cyclotron resonance mass spectrometer

Rooij

Duursma

Heeren

et al. 1996

J. Am. Soc. Mass Spectrom.

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Matrix-assisted laser desorption ionization was performed on an external ion source Fourier transform ion cyclotron resonance mass spectrometer equipped with a 7-T superconducting magnet to analyze end groups of synthetic polymers in the mass range from 500 to 5000 u. Native, perdeutero methylated, propylated, and acetylated polyethylene glycol and polyvinyl pyrrolidone with unknown end-group elemental composition were investigated in the mass range up to 5000 u by using a 2,5-dihydroxybenzoic acid matrix. A small electrospray setup was used for the deposition of the samples. Two methods to process data were evaluated for the determination of end groups from the measured masses of the component molecules in the molecular weight ranges: a regression method and an averaging method. The averaging method is demonstrated to allow end-group mass determinations with an accuracy within 3 mu for the molecular weight range from 500 to 1400 and within 20 mu for the molecular weight range from 3400 to 5000. This is sufficient to identify the elemental composition of end groups in unknown polymer samples.

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Accurate mass measurement in the absence of calibrant for capillary column gas chromatography/Fourier transform mass spectrometry

Cited by 21 publications

References 17 publications

Suspended trapping procedure for alleviation of space charge effects in gas chromatography/Fourier-transform mass spectrometry

Suspended trapping procedure for alleviation of space charge effects in gas chromatography/Fourier-transform mass spectrometry

High performance Fourier transform mass spectrometry for chemical analysis / Hochleistungs-Fourier-Massen-Spektrometrie in der chemischen Analytik

High resolution end group determination of low molecular weight polymers by matrix-assisted laser desorption ionization on an external ion source fourier transform ion cyclotron resonance mass spectrometer

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