Accurate identification of HLA-B*15:02 allele by two-dimensional polymerase chain reaction

Zhu, Xueting; Yu, Yang; Zhang, Jun; Zhan, Yuxia; Luo, Guanghua; Zheng, Lu

doi:10.1016/j.cca.2023.117654

Clinica Chimica Acta

2024

DOI: 10.1016/j.cca.2023.117654

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Accurate identification of HLA-B*15:02 allele by two-dimensional polymerase chain reaction

Xueting Zhu,

Yang Yu,

Jun Zhang

et al.

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Update on HLA-B15:02* Allele Associated with Adverse Drug Reactions

Zhu,

Luo,

Zheng

2024

Pharmacogenomics

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HLA alleles, part of the major histocompatibility complex, are strongly associated with adverse drug reactions (ADRs). This review focuses on HLA-B*15:02 and explores its association with ADRs in various ethnic populations and with different drugs, aiming to provide insights into the safe clinical use of drugs and minimize the occurrence of ADRs. Furthermore, the review explores the potential mechanisms by which HLA-B*15:02 may be associated with ADRs, aiming to gain new insights into drug modification and identification of haptens. In addition, it analyzes the frequency of the HLA-B*15:02, genotyping methods, cost–effectiveness and treatment measures for adverse reactions, thereby providing a theoretical basis for formulating clinical treatment plans.

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Update on HLA-B15:02* Allele Associated with Adverse Drug Reactions

Zhu,

Luo,

Zheng

2024

Pharmacogenomics

View full text Add to dashboard Cite

show abstract

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Accurate identification of HLA-B*15:02 allele by two-dimensional polymerase chain reaction

Cited by 1 publication

References 51 publications

Update on HLA-B15:02* Allele Associated with Adverse Drug Reactions

Update on HLA-B15:02* Allele Associated with Adverse Drug Reactions

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Accurate identification of HLA-B*15:02 allele by two-dimensional polymerase chain reaction

Cited by 1 publication

References 51 publications

Update on HLA-B*15:02 Allele Associated with Adverse Drug Reactions

Update on HLA-B*15:02 Allele Associated with Adverse Drug Reactions

Contact Info

Product

Resources

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Update on HLA-B15:02* Allele Associated with Adverse Drug Reactions

Update on HLA-B15:02* Allele Associated with Adverse Drug Reactions