Update on
HLA-B*15:02
Allele Associated with Adverse Drug Reactions
Xueting Zhu,
Guanghua Luo,
Lu Zheng
Abstract:HLA alleles, part of the major histocompatibility complex, are strongly associated with adverse drug reactions (ADRs). This review focuses on HLA-B*15:02 and explores its association with ADRs in various ethnic populations and with different drugs, aiming to provide insights into the safe clinical use of drugs and minimize the occurrence of ADRs. Furthermore, the review explores the potential mechanisms by which HLA-B*15:02 may be associated with ADRs, aiming to gain new insights into drug modification and ide… Show more
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