Accurate control of the heart rate in monkeys by burst stimulation of the vagus nerve

Pokrovskii, V. M.; Sheikh-Zade, Yu. R.; Kruchinin, V. M.; Urmancheeva, T. G.

doi:10.1007/bf00841984

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…The above-described phenomenon was studied in different animals species (monkey, cat, rabbit, dog, rat, guinea pig, coypu, pigeon, duck, frog). It has been reproduced in all tested animals and this similarity supports its general biological significance [16,17]. These facts demonstrate the existence of a robust general biological phenomenon by which bursts of impulses applied to the vagus nerve entrain the sinoatrial node and thus, the heart rate to the frequency of the bursts.…”

Section: Reproduction By the Heart Of The Rhythm Of Electrical Stimulsupporting

confidence: 74%

Integration Of The Heart Rhythmogenesis Levels: Heart Rhythm Generator In The Brain

Покровский

2006

Methodist DeBakey Cardiovascular Journal

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We propose that along with the intracardiac pacemaker, a generator of cardiac rhythm exists in the central nervous system -in the efferent structures of the cardiovascular center of the medullar oblongata. Signals in the medulla oblongata arise as a result of the hierarchic interaction of the brain structures. Neural signals originating there in the form of bursts of impulses conduct to the heart along the vagus nerves and after interaction with cardiac pacemaker structures, cause generation of the cardiac pulse in exact accordance with the frequency of "neural bursts". The intrinsic cardiac rhythm generator (the sinus node) is a life-sustaining factor that maintains the heart pumping function when the central nervous system is in a stage of deep inhibition, (e.g., under anesthesia or during unconsciousness). The brain generator is the factor that provides heart adaptive reactions in behaving organism. The integration of the two levels of rhythmogenesis in the brain and heart provides reliability and functional perfection of the cardiac rhythm generation system in the whole organism.

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Section: Reproduction By the Heart Of The Rhythm Of Electrical Stimulsupporting

confidence: 74%

Integration Of The Heart Rhythmogenesis Levels: Heart Rhythm Generator In The Brain

Покровский

2006

Methodist DeBakey Cardiovascular Journal

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show abstract

Section: Reproduction By the Heart Of The Rhythm Of Electrical Stimulsupporting

confidence: 74%

Integration of the Heart Rhythmogenesis Levels: Heart Rhythm Generator in the Brain

Pokrovskii

2005

J. Integr. Neurosci.

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We propose that along with the intracardiac pacemaker, a generator of cardiac rhythm exists in the central nervous system--in the efferent structures of the cardiovascular center of the medullar oblongata. Signals in the medulla oblongata arise as a result of the hierarchic interaction of the brain structures. Neural signals originating there in the form of bursts of impulses conduct to the heart along the vagus nerves and after interaction with cardiac pacemaker structures, cause generation of the cardiac pulse in exact accordance with the frequency of "neural bursts". The intrinsic cardiac rhythm generator (the sinus node) is a life-sustaining factor that maintains the heart pumping function when the central nervous system is in a stage of deep inhibition, (e.g., under anesthesia or during unconsciousness). The brain generator is the factor that provides heart adaptive reactions in behaving organism. The integration of the two levels of rhythmogenesis in the brain and heart provides reliability and functional perfection of the cardiac rhythm generation system in the whole organism.

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Integration of cardiac rhythmogenesis levels: cardiac rhythm generator in the brain

Pokrovsky¹

2006

Bûll. sib. med.

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Data which were obtained last time allow to re-comprehend ideas concerning mechanisms of cardiac rhythm regeneration and demonstrate existence of rhythm generator in the central nervous system in addition to such in the heart itself. Intracardiac generator is a life-supporting factor which supports pumping function of the heart while central nervous system is in deep inhibition status. Central generator provides adaptive reactions of the heart in natural medium. Integration of the two hierarchic levels of rhythmogenesis provides reliability and functional perfection of cardiac rhythm generation system in the organism.

show abstract

Accurate control of the heart rate in monkeys by burst stimulation of the vagus nerve

Cited by 3 publications

References 7 publications

Integration Of The Heart Rhythmogenesis Levels: Heart Rhythm Generator In The Brain

Integration Of The Heart Rhythmogenesis Levels: Heart Rhythm Generator In The Brain

Integration of the Heart Rhythmogenesis Levels: Heart Rhythm Generator in the Brain

Integration of cardiac rhythmogenesis levels: cardiac rhythm generator in the brain

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