Accuracy of the TIMI and GRACE scores in predicting coronary disease in patients with non-ST-elevation acute coronary syndrome

Hammami, R.; Jdidi, J.; Mroua, Fakher; Kallel, R.; Hentati, Mourad; Abid, Leïla; Kammoun, S.

doi:10.1016/j.repc.2017.05.012

Cited by 22 publications

(19 citation statements)

References 20 publications

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“…Several studies have previously reported the positive correlation between the GRACE score and other CAD severity assessment tools [12,13,[16][17][18][19][36][37][38][39][40]. Specifically, Hammami et al found that the GRACE score was significantly higher in UA and NSTEMI patients with a SYNTAX score ≥ 33, with a weak positive correlation reported between the two scores (r = 0.23) [16].…”

Section: Discussionmentioning

confidence: 98%

“…To date, several studies have investigated the correlation between risk-stratification scoring systems and the severity of CAD [11][12][13][14][15][16]. To our knowledge, only a limited number of them used the GRACE score to appreciate its reliability in predicting high-risk CAD and most of them solely enrolled patients with non-ST-elevation ACS [12,[17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Association of GRACE Risk Score with Coronary Artery Disease Complexity in Patients with Acute Coronary Syndrome

Sofidis

Otountzidis

Stalikas

et al. 2021

JCM

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The GRACE score constitutes a useful tool for risk stratification in patients with acute coronary syndrome (ACS), while the SYNTAX score determines the complexity of coronary artery disease (CAD). This study sought to correlate these scores and assess the accuracy of the GRACE score in predicting the extent of CAD. A total of 539 patients with ACS undergoing coronary angiography were included in this analysis. The patients were classified into those with a SYNTAX score < 33 and a SYNTAX score ≥ 33. Spearman’s correlation and receiver operator characteristic analysis were conducted to investigate the role of the GRACE score as a predictor of the SYNTAX score. There was a significantly positive correlation between the SYNTAX and the GRACE scores (r = 0.32, p < 0.001). The GRACE score predicted severe CAD (SYNTAX ≥ 33) moderately well (the area under the curve was 0.595 (0.522–0.667)). A GRACE score of 126 was documented as the optimal cut-off for the prediction of a SYNTAX score ≥ 33 (sensitivity = 53.5% and specificity = 66%). Therefore, our study reports a significantly positive correlation between the GRACE and the SYNTAX score in patients with ACS. Notably, NSTEMI patients with a high-risk coronary anatomy have higher calculated GRACE scores. A multidisciplinary approach by a heart team could possibly alter the therapeutic approach and management in patients presenting with ACS and a high calculated GRACE score.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Association of GRACE Risk Score with Coronary Artery Disease Complexity in Patients with Acute Coronary Syndrome

Sofidis

Otountzidis

Stalikas

et al. 2021

JCM

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“…In some studies, the association of other risk score systems like GRACE and TIMI were evaluated with regard to Syntax score (23)(24)(25). TIMI and GRACE are among scoring systems that were developed for risk strati cation of ACS patients in CCU (1).…”

Section: Discussionmentioning

confidence: 99%

The Potential of Heart Risk Score to Detect the Existence and Severity of Coronary Artery Disease According to Syntax Score at the Emergency Department

Drissi

Dehghani

Zolghadr

et al. 2021

Preprint

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Background: Patients presenting with chest pain (CP) at the emergency departments are challenging cases for the physicians to make valid decisions with regard to acute coronary syndrome, which needs urgent medical intervention while the majority of the admitted patients are free from serious cardiac problems. The present study was done to investigate the potential of Heart Risk Score in detecting the existence and severity of coronary artery disease in CP patients based on Syntax score.Methods: Among CP patients who were admitted at the emergency department, 100 participants were selected. Heart Risk Score was calculated for each participant on admission. Two independent cardiologists also calculated the Syntax score after angiography was done for each patient. Statistical analysis was performed to assess the correlation between Heart Risk Score and Syntax score.Results: The median age of participants was 58.42±12.42 with the majority (65%) being male. The mean Heart Risk Score of the patients was 5.76±1.56 (min=3, max=9) and the mean Syntax score was 14.82±11.42(min=0, max=44.5). Pearson correlation coefficient was 0.493 (P<0.001) between Heart Risk Score and Syntax score which was statistically significant (P<0.001). According to our findings a Heart Risk Score of more than 6 has a 52% sensitivity and a 74.7% specificity to detect extensive coronary artery involvement (Syntax score>22).Conclusion: We found that there is a positive and significant correlation between Heart Risk Score and Syntax score which underlines the importance of using Heart Risk Score in emergency departments to reduce unnecessary invasive interventions in patients presenting with chest pain.

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“…Besides, it was reported that GRACE score was correlated with degree of coronary stenosis reflected by SYNTAX score. [ 20 ] However, it did not concern the DAPT plan assignment. Another scoring tool, CRUSADE score, which was also derived from patients with ACS, could estimate bleeding risk and share several common indexes with GRACE score, such as heart rate, SBP, heart function, and renal function, indicating that patients with higher risk of coronary events might also have increased risk of bleeding.…”

Section: Discussionmentioning

confidence: 99%

Correlations of DAPT score and PRECISE-DAPT score with the extent of coronary stenosis in acute coronary syndrome

Long

Peng²,

Li³

et al. 2018

Medicine

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Dual antiplatelet therapy (DAPT) score and PRECISE-DAPT score were recommended for decision making of optimal DAPT in discriminating the risk of thrombosis and bleeding. But the relationships between 2 scoring tools with the extent of coronary stenosis have not been established.We retrospectively enrolled 359 patients of acute coronary syndrome (ACS) who received percutaneous coronary intervention. Both DAPT score and PRECISE-DAPT score were calculated, and patients were divided by their recommended cut-offs. Gensini score and triple-vessel disease (3-VD) were chosen to evaluate the severity of coronary stenosis.Overall, 54.9% and 10.0% of the patients had higher DAPT score (≥2) or PRECISE-DAPT score (≥25). Patients with higher DAPT score had increased stent counts, total length of stents, Gensini score, and proportion of 3-VD, but decreased minimum diameter of stent. But these differences were not found in PRECISE-DAPT subgroups. When divided into quartiles of both scoring systems, the highest Gensini score and proportions of 3-VD were found in the fourth quartile of both DAPT score and PRECISE-DAPT score. Moreover, both DAPT score and PRECISE-DAPT score were independent risk factors of Gensini score after adjustment (P < .001 and P = .047). Furthermore, an increase of 1 point of DAPT score and 5 points of PRECISE-DAPT score resulted by 51% (odds ratios [OR]: 1.51, 95% confidence interval [CI]:1.19–1.91, P = .001) and 34% (OR: 1.34, 95% CI: 1.11–1.62, P = .003) increase in risk of 3-VD after adjustment.Both DAPT score and PRECISE-DAPT score were independently associated with the degree of coronary stenosis in patients with ACS.

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Accuracy of the TIMI and GRACE scores in predicting coronary disease in patients with non-ST-elevation acute coronary syndrome

Abstract: The GRACE and TIMI scores correlate moderately with the extent of coronary disease assessed by the SYNTAX score. They can predict obstructive CAD but not severe disease.

Cited by 22 publications

References 20 publications

Association of GRACE Risk Score with Coronary Artery Disease Complexity in Patients with Acute Coronary Syndrome

Association of GRACE Risk Score with Coronary Artery Disease Complexity in Patients with Acute Coronary Syndrome

The Potential of Heart Risk Score to Detect the Existence and Severity of Coronary Artery Disease According to Syntax Score at the Emergency Department

Correlations of DAPT score and PRECISE-DAPT score with the extent of coronary stenosis in acute coronary syndrome

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