Accuracy of MRI in Diagnosing Peripheral Nerve Disease: A Systematic Review of the Literature

Kwee, Robert M.; Chhabra, Avneesh; Wang, Kenneth C.; Marker, David R.; Carrino, John A.

doi:10.2214/ajr.13.12403

Cited by 39 publications

(22 citation statements)

References 89 publications

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“…MRI neurography can be used to visualize peripheral nerves in humans 13, 14, 15, 16, 17. This method is useful to provide anatomical data and to detect pathologies such as tumors that affect the continuity of nerves 18, 19.…”

Section: Introductionmentioning

confidence: 99%

“…9,11,12 MRI neurography can be used to visualize peripheral nerves in humans. [13][14][15][16][17] This method is useful to provide anatomical data and to detect pathologies such as tumors that affect the continuity of nerves. 18,19 More recently, diffusion tensor imaging of peripheral nerves has been introduced as a tool to quantify nerve damage and regeneration.…”

Section: Introductionmentioning

confidence: 99%

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MRI biomarkers of proximal nerve injury in CIDP

Lichtenstein

Sprenger

Weiss

et al. 2017

Ann Clin Transl Neurol

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ObjectiveTo evaluate the utility of nerve diffusion tensor imaging (DTI), nerve cross‐sectional area, and muscle magnetic resonance imaging (MRI) multiecho Dixon for assessing proximal nerve injury in chronic inflammatory demyelinating polyneuropathy (CIDP).MethodsIn this prospective observational cohort study, 11 patients with CIDP and 11 healthy controls underwent a multiparametric MRI protocol with DTI of the sciatic nerve and assessment of muscle proton‐density fat fraction of the biceps femoris and the quadriceps femoris muscles by multiecho Dixon MRI. Patients were longitudinally evaluated by MRI, clinical examination, and nerve conduction studies at baseline and after 6 months.ResultsIn sciatic nerves of CIDP patients, mean cross‐sectional area was significantly higher and fractional anisotropy value was significantly lower, compared to controls. In contrast, muscle proton‐density fat fraction was significantly higher in thigh muscles of patients with CIDP, compared to controls. MRI parameters showed high reproducibility at baseline and 6 months.InterpretationAdvanced MRI parameters demonstrate subclinical proximal nerve damage and intramuscular fat accumulation in CIDP. Data suggest DTI and multiecho Dixon MRI might be useful in estimating axonal damage and neurogenic muscle changes in CIDP.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MRI biomarkers of proximal nerve injury in CIDP

Lichtenstein

Sprenger

Weiss

et al. 2017

Ann Clin Transl Neurol

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“…On axial T1-weighted MR images, nerves appear as hypointense dots embedded in hyperintense fatty tissue. 4 Few nerves accompany designated blood vessels, and it is easy to identify the nerves by virtue of the accompanying vessels. On US, a normal nerve shows as multiple small hypoechoic areas, the nerve bundles themselves separated by hyperechoic connective tissue, giving a honeycomb-like appearance in transverse section.…”

Section: Introductionmentioning

confidence: 99%

Nerve Entrapment in Ankle and Foot: Ultrasound Imaging

Chari

McNally

2018

Semin Musculoskelet Radiol

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Peripheral nerve entrapment of the ankle and foot is relatively uncommon and often underdiagnosed because electrophysiologic studies may not contribute to the diagnosis. Anatomy of the peripheral nerves is variable and complex, and along with a comprehensive physical examination, a thorough understanding of the applied anatomy is essential. Several studies have helped identify specific areas in which nerves are commonly compressed. Identified secondary causes of nerve compression include previous trauma, osteophytes, ganglion cysts, edema, accessory muscles, tenosynovitis, vascular lesions, and a primary nerve tumor. Imaging plays a key role in identifying primary and secondary causes of nerve entrapment, specifically ultrasound (US) and magnetic resonance imaging. US is a dynamic imaging modality that is cost effective and offers excellent resolution. Symptoms of nerve entrapment may mimic other common foot and ankle conditions such as plantar fasciitis.

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“…[10][11][12] MRI has become a main diagnostic tool to assess the location and extent of nerve injury and to monitor its regenerative process. [13][14][15] Superparamagnetic iron oxide (SPIO) nanoparticle-based contrast agents can be phagocytosed by reticuloendothelial system cells and taken up by monocytes in the circulation after intravenous injection. 16 Combined with the use of SPIO, MRI has been successfully used to detect macrophage infiltration in inflammatory diseases.…”

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confidence: 99%