Accuracy of Magnetic Resonance Imaging for Local Staging of Prostate Cancer: A Diagnostic Meta-analysis

Rooij, Maarten de; Hamoen, E.H.J.; Witjes, J. Alfred; Barentsz, Jelle O.; Rovers, Maroeska M.

doi:10.1016/j.eururo.2015.07.029

Cited by 495 publications

(384 citation statements)

References 91 publications

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“…2, 3). Median sensitivities were modest and specificities were excellent, and similar to a recently published systematic review/meta-analysis 29 (Table 2). …”

Section: Key Evidencesupporting

confidence: 51%

“…Our systematic review of the literature is consistent with a well-conducted, recently published systematic review/ meta-analysis that reported overall sensitivity of approximately 50-60% and specificity of >85%, despite differences in methodology (e.g., years searched) and analyzed studies (e.g., ER, field strength, mpMRI). 29 In our work, above average sensitivities were achieved in some studies; however, whether this was due to the addition of functional sequences or field strength was not clear owing to too few studies (Table 3). Other reports of sensitivity and specificity of MRI for local staging of prostate cancer range from 15-100% and 67-100%, respectively.…”

Section: Discussionmentioning

confidence: 92%

“…Among non-ER studies, 1.5 T had a lower sensitivity than 3 T (Table 2), which was also consistent with a previous detailed analysis. 29 The quality assessment of ER studies on imaging performance was judged to be of high risk. Explanations surround the lack of detail reported for radiology and pathology evaluation and interpretation, and the difficulty in distinguishing between microscopic to gross EPE.…”

Section: Discussionmentioning

confidence: 99%

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Multiparametric magnetic resonance imaging for pre-treatment local staging of prostate cancer: A Cancer Care Ontario clinical practice guideline

Salerno

Finelli

Morash

et al. 2016

CUAJ

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Introduction: The utility of T2-weighted magnetic resonance imaging (MRI) in the local staging of prostate cancer is controversial. Due to the success of multiparametric MRI in cancer localization, there is renewed interested in MRI (± functional sequences) for local staging. Guidance on pre-treatment local staging of prostate cancer by MRI was developed using systematic review methodology and expert consultation. Methods: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and other databases were searched to identify studies comparing: (1) MRI staging vs. radical prostatectomy staging on diagnostic accuracy outcomes; and (2) MRI staging vs. routine clinical staging on clinical and patient outcomes. Studies meeting inclusion criteria were synthesized by outcome and sensitivity/ specificity analysis by tumour location was performed. Evidence quality of included studies was assessed and considered in recommendation formulation. Results: The literature search identified 2510 citations; 62 studies were included. Analysis of MRI ≥1.5 T plus endorectal coil (ER) (± functional sequences) in the detection of extraprostatic extension or seminal vesicle invasion showed modest sensitivities (≥50%) and excellent specificities (>85%) among patients scheduled for radical prostatectomy. MRI upstaging was shown in 20/21 studies, with large variation in correctness (11-85%). Scarcity of clinical and patient outcomes among studies limited synthesis and evaluation. Quality assessment found non-trivial biases. Conclusions: Modest imaging performance was shown for MRI (1.5 T + ER and 3 T ± ER) ± functional sequences in regards to sensitivity. Limitations in study design, reporting of clinical and patient outcomes, and the heterogeneous use of MRI tempered the strength of the recommendations.

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“…2, 3). Median sensitivities were modest and specificities were excellent, and similar to a recently published systematic review/meta-analysis 29 (Table 2). …”

Section: Key Evidencesupporting

confidence: 51%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Multiparametric magnetic resonance imaging for pre-treatment local staging of prostate cancer: A Cancer Care Ontario clinical practice guideline

Salerno

Finelli

Morash

et al. 2016

CUAJ

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“…The goal of RP is eradication of PCa, while preserving continence and, whenever possible, [46]. But the experience of the radiologist remains of paramount importance.…”

Section: Radical Prostatectomymentioning

confidence: 99%

EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

et al. 2017

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“…The sole use of a body phased-array coil at 3 T as widely used in practice is justified by the good detection of significant tumors [28]. Use of the combined endorectal body phased-array coil at 3 T can improve local staging, particularly the evaluation of extracapsular growth [35]. When using an endorectal coil, it should be filled with air.…”

Section: Endorectal Coilmentioning

confidence: 99%

MRT der Prostata: Empfehlungen zur Vorbereitung und Durchführung

Franiel

Quentin

Mueller‐Lisse³

et al. 2016

Fortschr Röntgenstr

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The Working Group Uroradiology and Urogenital Diagnosis of the German Roentgen Society has developed uniform recommendations for the preparation and implementation of prostate MRI. In the first part detailed recommendations are given in tabular form regarding 1. anamnestic data before prostate MRI, 2. termination of examinations and preparation of examinations, 3. examination protocol and 4. MRI-guided in-bore biopsy. In the second part, the recommendations are discussed in detail and relevant background information is provided. Key Points: Citation Format

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Accuracy of Magnetic Resonance Imaging for Local Staging of Prostate Cancer: A Diagnostic Meta-analysis

Cited by 495 publications

References 91 publications

Multiparametric magnetic resonance imaging for pre-treatment local staging of prostate cancer: A Cancer Care Ontario clinical practice guideline

Multiparametric magnetic resonance imaging for pre-treatment local staging of prostate cancer: A Cancer Care Ontario clinical practice guideline

EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent

MRT der Prostata: Empfehlungen zur Vorbereitung und Durchführung

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