Accuracy of indocyanine green pulse spectrophotometry clearance test for liver function prediction in transplanted patients

Abstract

ICG pulse spectrophotometry clearance is a quick, non-invasive, and reliable liver function test in transplantation patients.

Nicht-Isotopen Tyrosin-Kinetik mit dem Dipeptid Alanyl-Tyrosin zur Beurteilung der Organfunktion bei Lebertransplantation – eine Pilotstudie

“…Patients with clinically poor graft function but normal hepatic arterial and portal vein flow as demonstrated by Doppler ultrasound sonography exhibited low ICGPDR values equivalent to recently published cut-off values indicating severe impairment [18,[22][23][24]33]. Baseline tyrosine plasma levels were severely elevated and tyrosine clearance delayed.…”

“…ICG clearance shows good correlation with overall liver function and has some predictive value for graft survival. However, its dependence on hepatic blood flow and protein binding, which compromises assessment of the metabolic state of the liver, has prevented widespread use of the ICG test in clinical practice [24,33].…”

Bile-Reflux into the Pancreatic Ducts is Associated with the Development of Intraductal Papillary Carcinoma in Hamsters

“…In the present study, we prepared three different hamster models with the aim of handling the bile flow, and the main pancreatic ducts only in the Model A hamsters were clearly dyed green after the injection of ICG via the portal vein. ICG, a watersoluble tricarbocyanine dye, is metabolized in the liver through an uptake across the sinusoidal plasma membrane and then excreted into the bile [35,36]. The evidence of pancreatic ductal staining with ICG, therefore, indicated that the bile did flow into the pancreatic ducts of the Model A hamsters.…”

Quantitative Assessment of Hepatic Function and its Relevance to the Liver Surgeon

“…41 Hsieh and colleagues compared the two modalities in 13 patients undergoing liver transplantation and found an excellent correlation between the standard and densiometry methods with a correlation coefficient r 2 of 0.977. 42 Hori and colleagues monitored 30 adult living donor recipients for 28 days following surgery using ICG-K as determined noninvasively by spectrophotometry and compared their results to results of liver scintigraphy and histological changes. They found that measuring ICG in this way accurately predicted clinical outcomes.…”