Bile-Reflux into the Pancreatic Ducts is Associated with the Development of Intraductal Papillary Carcinoma in Hamsters

Adachi, Tomohiko; Tajima, Yoshitsugu; Kuroki, Tamotsu; Mishima, Takehiro; Kitasato, Amane; Fukuda, Kenzo; Tsutsumi, Ryuji; Kanematsu, Takashi

doi:10.1016/j.jss.2006.04.025

Cited by 28 publications

(19 citation statements)

References 31 publications

(28 reference statements)

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“…While the incidence of pancreatic cancer was reported to be 0.0162 % in the overall population in Japan, in patients with PBM this incidence reached 0.8 %, a 49.4-fold increase compared with that in the overall population [102]. There is evidence of an association between bile reflux into the pancreatic duct and the development of pancreatic cancer [103], although because this study was based on animal experiments it cannot be considered to provide sufficient evidence to support a cause-and-effect relationship between PBM and pancreatic carcinogenesis. Thus, it still remains unclear whether or not patients with PBM are more susceptible to pancreatic cancer than other individuals.…”

Section: Commentsmentioning

confidence: 97%

Japanese clinical practice guidelines for pancreaticobiliary maljunction

et al. 2012

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There have been no clinical guidelines for the management of pancreaticobiliary maljunction (PBM). The Japanese Study Group on Pancreaticobiliary Maljunction (JSPBM) has proposed to establish clinical practice guidelines on how to deal with PBM, with the support of the Japan Biliary Association (JBA). Because the body of evidence-based literature is relatively small, we decided to create guidelines based on the consensus of experts, using the medical literature for reference. A total of 46 clinical questions (CQs) were considered by the members of the editorial committee responsible for the guidelines. The CQs covered distinct aspects of PBM: (1) Concepts and Pathophysiology (10 CQs); (2) Diagnosis (10 CQs); (3) Pancreatobiliary complications (9 CQs); and (4) Treatments and prognosis (17 CQs). Statements and comments for each CQ were prepared by the guidelines committee members and collaborating partners. The CQs were completed after review by members of the editorial committee, meetings of this committee, public comments on the homepages of the JSPBM and the JBA, public hearings, and assessment and approval by the guidelines evaluation board. PBM includes cases where the bile duct is dilated (PBM with biliary dilatation) and those in which it is not (PBM without biliary dilatation). In these guidelines, PBM with biliary dilatation is defined as being identical to congenital biliary dilatation of Todani type I (except for type Ib) and type IV-A, both of which are accompanied by PBM in almost all cases. These guidelines are created to provide assistance in the clinical practice of PBM management; their contents focus on clinical utility, and they include general information on PBM to make this disease more widely recognized.

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Section: Commentsmentioning

confidence: 97%

Japanese clinical practice guidelines for pancreaticobiliary maljunction

et al. 2012

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“…Furthermore, BAs were also found to be etiologic agents of other GI tract cancers, namely that of the esophagus [5], stomach [6], small intestine [7], liver [8], pancreas [9] and biliary tract [10]. …”

Section: Introductionmentioning

confidence: 99%

Secondary bile acids: an underrecognized cause of colon cancer

2014

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Bile acids were first proposed as carcinogens in 1939. Since then, accumulated evidence has linked exposure of cells of the gastrointestinal tract to repeated high physiologic levels of bile acids as an important risk factor for gastrointestinal cancers. High exposure to bile acids may occur in a number of settings, but most importantly, is prevalent among individuals who have a high dietary fat intake.A rapid effect on cells of high bile acid exposure is the generation of reactive oxygen species and reactive nitrogen species, disruption of the cell membrane and mitochondria, induction of DNA damage, mutation and apoptosis, and development of reduced apoptosis capability upon chronic exposure. Here, we review the substantial evidence of the mechanism of secondary bile acids and their role in colon cancer.

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“…Both anomalies were in association with a pancreatic cancer. While it is speculative to explain this association as an etiopathogenetic link, we cannot exclude that the probable bile-reflux into the pancreatic ducts, due to gallbladder anomalies, might be associated with the development of carcinoma, as previously documented in the literature [5]. …”

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confidence: 71%