Accuracy of Glycosylated Hemoglobin in HIV/AIDS Hyperglycemic Diabetic Patients: A Comparative Study

Singh, Lakhan; Thakur, Hemlata; Nigam, Pramod

doi:10.5958/0976-5506.2016.00034.6

Cited by 2 publications

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“…Glesby et al 36 found women with HIV had an HbA 1c 1.32% lower compare to an HIV‐uninfected woman with the same log fasting glucose concentration. Singh et al 37 quoted HbA 1c to underestimate glucose by 1.5 ± 0.2 mmol/l (27 ± 4 mg/dl).…”

Section: Resultsmentioning

confidence: 99%

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The investigation of diabetes in people living with HIV: A systematic review

et al. 2020

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Aims HbA1c is reported to underestimate glycaemia in people living with HIV (PLHIV). There is not an internationally agreed screening method for diabetes. The primary aim was to identify which tests are performed to diagnose and monitor diabetes in PLHIV. Secondary aims were to identify whether prevalence or incidence of diabetes differs according to marker of glycaemia and how figures compare in PLHIV compared to people without. Methods Electronic databases were searched for studies investigating diabetes in PLHIV, not pregnant, aged ≥18 years. Narrative analysis and descriptive statistics were used to describe which markers of glycaemia, and their frequency, were employed in the diagnosis and monitoring of diabetes in PLHIV. Diagnostic studies provided prevalence or incidence of diabetes. Results In all, 45 of 1028 studies were included. Oral glucose tolerance test (OGTT), fasting glucose (FG), HbA1c and Fructosamine were used to investigate diabetes. In total, 27 studies described diagnosing diabetes, 14 using OGTT, 12 FG and 7 HbA1c. All 18 studies monitoring diabetes used HbA1c. Prevalence ranged from 1.3% to 26% and incidence 2.9% to 12.8%. Studies using glucose and HbA1c reported HbA1c to diagnose fewer people with diabetes, monitoring studies found HbA1c to underestimate glycaemia levels. Controlled studies demonstrate diabetes was more common in PLHIV. Conclusion OGTT was used most frequently to diagnose diabetes, and HbA1c to monitor known diabetes. Prevalence and incidence varied depending on marker of glycaemia used. Studies reported a discrepancy in accuracy of HbA1c in PLHIV, to address this, well‐designed, prospective studies, providing individual‐level data on HbA1c levels and an additional marker of glycaemia in PLHIV are needed.

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Section: Resultsmentioning

confidence: 99%

“…Six studies used fasting glucose as an additional marker of glycaemia 13,34‐37 to monitor diabetes with one study 38 also using Fructosamine, five 13,34‐37 included a control cohort of participants without HIV. Four of the controlled studies compared HbA 1c and FG values.…”

Section: Resultsmentioning

confidence: 99%

The investigation of diabetes in people living with HIV: A systematic review

et al. 2020

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HIV and type 2 diabetes: An evolving story

Daultrey,

Levett,

Oliver

et al. 2023

HIV Medicine

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IntroductionDiabetes is widely reported to be more common in people living with HIV (PLWH). Much of the data supporting this originated during the earlier HIV era. The perceived increased risk of type 2 diabetes is reflected in HIV clinical guidelines that recommend screening for diabetes in PLWH on anti‐retroviral therapy (ART). However, international HIV clinical guidelines do not agree on the best marker of glycaemia to screen for diabetes. This stems from studies that suggest HbA1c underestimates glycaemia in PLWH.MethodsWithin this review we summarise the literature surrounding the association of HIV and type 2 diabetes and how this has changed over time. We also present the evidence on HbA1c discrepancy in PLWH.ConclusionWe suggest there is no basis to any international guidelines to restrict HbA1c based on HIV serostatus. We recommend, using the current evidence, that PLWH should be screened annually for diabetes in keeping with country specific guidance. Finally, we suggest future work to elucidate phenotype and natural history of type 2 diabetes in PLWH across all populations.

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Accuracy of Glycosylated Hemoglobin in HIV/AIDS Hyperglycemic Diabetic Patients: A Comparative Study

Cited by 2 publications

References 0 publications

The investigation of diabetes in people living with HIV: A systematic review

The investigation of diabetes in people living with HIV: A systematic review

HIV and type 2 diabetes: An evolving story

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