Accuracy of Gadofosveset-enhanced MRI for Nodal Staging and Restaging in Rectal Cancer

Lambregts, Doenja M. J.; Beets, Geerard L.; Maas, Monique; Kessels, Alfons G.H.; Bakers, Frans C. H.; Cappendijk, Vincent C.; Engelen, Sanne; Lahaye, Max J.; Bruïne, Adriaan P. de; Lammering, Guido; Leiner, Tim; Verwoerd, Jan L.; Wildberger, Joachim E.

doi:10.1097/sla.0b013e31820b01f1

Cited by 129 publications

(76 citation statements)

References 30 publications

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“…Patients with rectal cancer have a 29 to 52 % risk for lymph node metastasis [5][6][7][8] resulting in an inferior long-term survival and a higher risk for local recurrences of the tumor [9][10][11]. Therefore, many studies have focused on the ability to predict pN+ through MRI.…”

Section: Discussionmentioning

confidence: 98%

Clinical relevance of morphologic MRI criteria for the assessment of lymph nodes in patients with rectal cancer

Doyon

Attenberger

Dinter

et al. 2015

Int J Colorectal Dis

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Section: Discussionmentioning

confidence: 98%

Clinical relevance of morphologic MRI criteria for the assessment of lymph nodes in patients with rectal cancer

Doyon

Attenberger

Dinter

et al. 2015

Int J Colorectal Dis

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“…(Lambregts et al, 2011). Furthermore, a few of these advanced modalities are still inaccessible in developing areas like China.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Magnetic Resonance Imaging in Pretreatment Lymph Node Assessment for Gynecological Malignancies

Sufian¹,

Masroor²,

Mirza³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Objective: To determine the accuracy of magnetic resonance imaging (MRI) in detection of metastasis in pelvic and para-aortic lymph nodes from different gynecological malignancies. Materials and Methods: This retrospective cross sectional analytic study was conducted at the Department of Diagnostic Radiology, Aga Khan University Hospital Karachi Pakistan from January 2011 to December 2012. A sample of 48 women, age range between 20-79 years, fulfilling inclusion criteria were included. All patients had histopathologically proven gynecological malignancies in the cervix, endometrium or ovary and presented for a pretreatment MRI to our radiology department. Results: MRI was 100% sensitive and had a 100% positive predictive value to detect lymph node metastasis in lymph nodes with spiculated margins and 100% sensitive with a 75% positive predictive value to detect lymph node metastasis in a lymph node with lobulated margins. The sensitivity and positive predictive value of MRI to detect heterogeneous nodal enhancement were 100% and 75% respectively. Conclusions: Our study results reinforce that MRI should be used as a modality of choice in the pretreatment assessment of lymph nodes in proven gynaecological malignancies in order to determine the line of patientmanagement, distinguishing surgical from non-surgical cases.

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“…Many of these compounds are in preclinical development, but at present only MS-325 (gadofosveset), a gadolinium chelate that is chemically modified causing it to bind strongly but reversibly to plasma albumin, is available for clinical use [24]. Lambregts et al [25 ]reported on the use of gadofosveset-enhanced MRI for nodal staging in rectal cancer. When comparing it to histology as the standard, they found that sensitivity and specificity improved from 76 and 82% to 80 and 97%, respectively, when using gadofosveset (p < 0.001).…”

Section: Gadolinium-based Blood Pool Agentsmentioning

confidence: 99%

Innovation in Cancer Imaging

Debergh

Vanhove²,

Ceelen³

2012

Eur Surg Res

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Cancer is rapidly becoming the worldwide leading cause of premature death. Iconographic techniques have traditionally provided information on tumor anatomy. The recent introduction of functional and molecular imaging techniques allows probing tumor physiology and biology in addition to mere anatomical description. In addition to the research implications, these novel imaging techniques offer early response assessment and target visualization which, in the era of personalized medicine, may offer significant advances in cancer therapy. Here, we provide an overview of the most important developments in cancer imaging, with a focus on the clinical applications.

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Accuracy of Gadofosveset-enhanced MRI for Nodal Staging and Restaging in Rectal Cancer

Abstract: This study shows high reproducibility and significantly improved accuracy compared to standard MRI for gadofosveset-enhanced MRI for nodal staging and restaging in rectal cancer.

Cited by 129 publications

References 30 publications

Clinical relevance of morphologic MRI criteria for the assessment of lymph nodes in patients with rectal cancer

Clinical relevance of morphologic MRI criteria for the assessment of lymph nodes in patients with rectal cancer

Accuracy of Magnetic Resonance Imaging in Pretreatment Lymph Node Assessment for Gynecological Malignancies

Innovation in Cancer Imaging

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