Innovation in Cancer Imaging

Debergh, Isabelle; Vanhove, Christian; Ceelen, Wim

doi:10.1159/000338193

Cited by 5 publications

(4 citation statements)

References 91 publications

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“…This non-ionizing imaging technique provides to the surgeons, in a real-time manner and at a high signal-to-noise ratio (SNR), sensitive molecular information that optimizes tumor resection and thus the patient's health and life quality. For instance, conventional endoscopy has been coupled with fluorescent imaging probes, increasing the early diagnosis of colorectal cancers [33]. To the best of our knowledge, no optical imaging procedure has yet been proposed for thyroid cancer, although its anatomical accessibility would qualify this pathology as an ideal candidate.…”

Section: Introductionmentioning

confidence: 99%

Molecular Imaging of Galectin-1 Expression as a Biomarker of Papillary Thyroid Cancer by Using Peptide-Functionalized Imaging Probes

Fanfone

Stanicki²,

Nonclercq

et al. 2020

Biology

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Thyroid cancers are the most frequent endocrine cancers and their incidence is increasing worldwide. Thyroid nodules occur in over 19–68% of the population, but only 7–15% of them are diagnosed as malignant. Diagnosis relies on a fine needle aspiration biopsy, which is often inconclusive and about 90% of thyroidectomies are performed for benign lesions. Galectin-1 has been proposed as a confident biomarker for the discrimination of malignant from benign nodules. We previously identified by phage display two peptides (P1 and P7) targeting galectin-1, with the goal of developing imaging probes for non-invasive diagnosis of thyroid cancer. The peptides were coupled to ultra-small superparamagnetic particles of iron oxide (USPIO) or to a near-infrared dye (CF770) for non-invasive detection of galectin-1 expression in a mouse model of papillary thyroid cancer (PTC, as the most frequent one) by magnetic resonance imaging and fluorescence lifetime imaging. The imaging probes functionalized with the two peptides presented comparable image enhancement characteristics. However, those coupled to P7 were more favorable, and showed decreased retention by the liver and spleen (known for their galectin-1 expression) and high sensitivity (75%) and specificity (100%) of PTC detection, which confirm the aptitude of this peptide to discriminate human malignant from benign nodules (80% sensitivity, 100% specificity) previously observed by immunohistochemistry.

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Section: Introductionmentioning

confidence: 99%

Molecular Imaging of Galectin-1 Expression as a Biomarker of Papillary Thyroid Cancer by Using Peptide-Functionalized Imaging Probes

Fanfone

Stanicki²,

Nonclercq

et al. 2020

Biology

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“…Moreover, it has been shown that multitasking diagnostics that combine techniques such as PET (positron emission tomography) and MRI (magnetic resonance imaging) could be really improved if effective multimodal contrast agents exist . The fact that PET images provide functional information about the disease with high sensitivity speeds up the development of clinical PET and hybrid PET/computed tomography (CT) cameras. Although PET imaging provides information about physiological and pathophysiological processes, such a technique is limited by the low anatomical resolution .…”

Section: Introductionmentioning

confidence: 99%

Ultrasmall particles for Gd‐MRI and ⁶⁸Ga‐PET dual imaging

Truillet

Bouziotis

Tsoukalas

et al. 2014

Contrast Media & Molecular

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Nanoparticles made of a polysiloxane matrix and surrounded by 1,4,7,10-tetraazacyclododecane-1-glutaric anhydride-4,7,10-triacetic acid (DOTAGA)[Gd(3+) ] and 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid) NODAGA[(68) Ga(3+) ] have been synthesized for positron emission tomography/magnetic resonance (PET/MRI) dual imaging. Characterizations were carried out in order to determine the nature of the ligands available for radiolabelling and to quantify them. High radiolabelling purity (>95%) after (68) Ga labelling was obtained. The MR and PET images demonstrate the possibility of using the nanoparticles for a combined PET/MR imaging scanner. The images show fast renal elimination of the nanoparticles after intravenous injection.

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“…Another MRI imaging model for liver regeneration could reliably and reproducibly quantify the proliferative rate of hepatocytes using MRI in rodents [11]. MRI plays an important role in the molecular and functional imaging of cancer [12]. Our group has published interesting results for noninvasive monitoring of tumor growth in a murine model for pancreatic cancer [13] and for tumor growth of pancreatic cancer following surgical trauma [14].…”

Section: Discussionmentioning

confidence: 99%

The MRI Sepsis Score: An Innovative Tool for the Evaluation of Septic Peritonitis in Mice Using 7-Tesla Small Animal MRI

et al. 2018

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Background: Magnetic resonance imaging (MRI) techniques are rarely used in the context of abdominal sepsis and in sepsis research. This study investigates the impact of MRI for monitoring septic peritonitis in an animal model (colon ascendens stent-induced peritonitis, CASP). The CASP model closely mimics that of human disease and is highly standardized. The most frequently employed readout parameter in mouse CASP studies is prolonged or decreased rate of survival. Monitoring the progression of peritonitis via MRI could provide a helpful tool in the evaluation of severity. The use of alternative readout systems could very well reduce the number of research animals. Perspectively, clinical improvement after certain treatment could be classified. Methods: This study describes for the first time MRI findings following the induction of septic peritonitis in mice using the CASP model. Two sublethal groups of mice with septic peritonitis were investigated. Each had received one of two differing stent diameters in order to control the leakage of feces into the abdominal cavity. Each mouse served as its own control. Imaging and analyses were performed blinded. Gut diameters, stomach volume, abdominal organ wall diameters, and volume of the adrenal glands were measured. Serum corticosterone levels were detected using ELISA. Serum IL-6, TNF-α, IL-1β, and IL-10 levels were screened by cytometric bead array. Statistical analysis was performed using the Mann-Whitney U test for nonparametric probes and the Kruskal-Wallis and t tests. Results: Using a 7-tesla MRI scanner 24 and 48 h after induction of septic peritonitis, interenteric fluid, organ swelling of spleen and adrenal glands, as well as dilatation of the stomach were compared to nonseptic conditions. Swelling of adrenal glands resulted in an increased serum corticosterone level. In addition, the wall of the intestine bowel was thickened. Based upon these findings, an MRI score (MRI sepsis score, MSS) for abdominal sepsis in mice was established. Reduced stent sizes led to reduced severity of the abdominal sepsis, which could be reproduced in the MSS, which is described here for the first time. Conclusions: Intraabdominal variations during septic peritonitis are detectable by MRI techniques. MRI methods should become a more important tool for the evaluation of abdominal peritonitis. MSS could provide an interesting tool for the evaluation of therapeutic strategies.

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Innovation in Cancer Imaging

Cited by 5 publications

References 91 publications

Molecular Imaging of Galectin-1 Expression as a Biomarker of Papillary Thyroid Cancer by Using Peptide-Functionalized Imaging Probes

Molecular Imaging of Galectin-1 Expression as a Biomarker of Papillary Thyroid Cancer by Using Peptide-Functionalized Imaging Probes

Ultrasmall particles for Gd‐MRI and ⁶⁸Ga‐PET dual imaging

The MRI Sepsis Score: An Innovative Tool for the Evaluation of Septic Peritonitis in Mice Using 7-Tesla Small Animal MRI

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Innovation in Cancer Imaging

Cited by 5 publications

References 91 publications

Molecular Imaging of Galectin-1 Expression as a Biomarker of Papillary Thyroid Cancer by Using Peptide-Functionalized Imaging Probes

Molecular Imaging of Galectin-1 Expression as a Biomarker of Papillary Thyroid Cancer by Using Peptide-Functionalized Imaging Probes

Ultrasmall particles for Gd‐MRI and 68Ga‐PET dual imaging

The MRI Sepsis Score: An Innovative Tool for the Evaluation of Septic Peritonitis in Mice Using 7-Tesla Small Animal MRI

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Product

Resources

About

Ultrasmall particles for Gd‐MRI and ⁶⁸Ga‐PET dual imaging