“…Only one paper 31 was considered with a low risk of bias in all four domains. On the other hand, three studies 32,34,35 (n = 141, 36.9%) showed a high risk of bias in at least one domain. In particular, two studies 32,35 (n = 85, 22.2%) presented high risk of bias in the “index test” domain due to the absence of an ultrasound guide during the execution of the exam.…”
Section: Resultsmentioning
confidence: 95%
“…On the other hand, three studies 32,34,35 (n = 141, 36.9%) showed a high risk of bias in at least one domain. In particular, two studies 32,35 (n = 85, 22.2%) presented high risk of bias in the “index test” domain due to the absence of an ultrasound guide during the execution of the exam. Moreover, two studies 32,35 (n = 117, 30.6%) showed a high risk of bias in the “reference standard” domain.…”
Section: Resultsmentioning
confidence: 95%
“…We excluded 1499 published studies after scanning their titles and abstracts, and full‐texts of the remaining 23 papers were obtained and reviewed. After applying the abovementioned eligibility criteria, a total of eight studies 19,29‐35 were included in the qualitative and quantitative synthesis. The reasons behind the exclusions of 15 studies are shown in Figure 1.…”
Section: Resultsmentioning
confidence: 99%
“…In particular, two studies 32,35 (n = 85, 22.2%) presented high risk of bias in the “index test” domain due to the absence of an ultrasound guide during the execution of the exam. Moreover, two studies 32,35 (n = 117, 30.6%) showed a high risk of bias in the “reference standard” domain. In particular, lymph nodes were analyzed at the histopathology exam only after a positive FNAC results, while patients with negative FNAC results underwent clinical and radiological follow‐up.…”
Purpose
To define the accuracy of fine‐needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients.
Methods
The study was performed according to the PRISMA‐DTA guidelines.
Results
A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%‐80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%‐93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89‐38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3‐11.2) and 0.37 (95% CI: 0.22‐0.54), respectively.
Conclusions
FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.
“…Only one paper 31 was considered with a low risk of bias in all four domains. On the other hand, three studies 32,34,35 (n = 141, 36.9%) showed a high risk of bias in at least one domain. In particular, two studies 32,35 (n = 85, 22.2%) presented high risk of bias in the “index test” domain due to the absence of an ultrasound guide during the execution of the exam.…”
Section: Resultsmentioning
confidence: 95%
“…On the other hand, three studies 32,34,35 (n = 141, 36.9%) showed a high risk of bias in at least one domain. In particular, two studies 32,35 (n = 85, 22.2%) presented high risk of bias in the “index test” domain due to the absence of an ultrasound guide during the execution of the exam. Moreover, two studies 32,35 (n = 117, 30.6%) showed a high risk of bias in the “reference standard” domain.…”
Section: Resultsmentioning
confidence: 95%
“…We excluded 1499 published studies after scanning their titles and abstracts, and full‐texts of the remaining 23 papers were obtained and reviewed. After applying the abovementioned eligibility criteria, a total of eight studies 19,29‐35 were included in the qualitative and quantitative synthesis. The reasons behind the exclusions of 15 studies are shown in Figure 1.…”
Section: Resultsmentioning
confidence: 99%
“…In particular, two studies 32,35 (n = 85, 22.2%) presented high risk of bias in the “index test” domain due to the absence of an ultrasound guide during the execution of the exam. Moreover, two studies 32,35 (n = 117, 30.6%) showed a high risk of bias in the “reference standard” domain. In particular, lymph nodes were analyzed at the histopathology exam only after a positive FNAC results, while patients with negative FNAC results underwent clinical and radiological follow‐up.…”
Purpose
To define the accuracy of fine‐needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients.
Methods
The study was performed according to the PRISMA‐DTA guidelines.
Results
A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%‐80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%‐93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89‐38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3‐11.2) and 0.37 (95% CI: 0.22‐0.54), respectively.
Conclusions
FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.
“…Nonetheless a quick evaluation of a neck node or a parotid tumor is essential to establish the right treatment plan for the patient. Thus, FNAC is a rapid and minimal invasive diagnostic tool [5]. The accuracy of an FNAC strongly depends on the experience of the physician performing the FNAC and on the expertise of the examining pathologist [6,7].…”
Fine needle aspiration cytology (FNAC) is an important diagnostic tool for tumors of the head and neck. However, non-diagnostic or inconclusive results may occur and lead to delay in treatment. The aim of this study was to evaluate the factors that predict a successful FNAC. A retrospective search was performed to identify all patients who received an FNAC at the Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna. The variables were patients’ age and sex, localization and size of the punctured structure, previous radiotherapy, experience of the head and neck surgeon, experience of the pathologist and the FNAC result. Based on these parameters, a nomogram was subsequently created to predict the probability of accurate diagnosis. After performing 1221 FNACs, the size of the punctured lesion (p = 0.0010), the experience of the surgeon and the pathologist (p = 0.00003) were important factors for a successfully procedure and reliable result. FNACs performed in nodes smaller than 20 mm had a significantly worse diagnostic outcome compared to larger nodes (p = 0.0004). In conclusion, the key factors for a successful FNAC are nodal size and the experience of the head and neck surgeon and the pathologist.
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