Accuracy of Digital Breast Tomosynthesis for Depicting Breast Cancer Subgroups in a UK Retrospective Reading Study (TOMMY Trial)

Gilbert, Fiona J.; Tucker, Lorraine; Gillan, Maureen Gc; Willsher, Paula; Cooke, Julie; Duncan, Karen A.; Michell, Michael; Dobson, H.; Lim, Yit Yoong; Suaris, Tamara; Astley, Susan M.; Morrish, Oliver; Young, Kenneth C.; Duffy, Stephen W.

doi:10.1148/radiol.2015142566

Cited by 157 publications

(130 citation statements)

References 30 publications

(36 reference statements)

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“…This study showed a high sensitivity and specificity of DBT over DM. This advantage of DBT over DM provides two main benefits, namely increased rates of cancer detection and reduced callback rates [15-18, 23]. …”

Section: Discussionmentioning

confidence: 99%

“…By combining information from different projections, DBT improves the differentiation of the adjacent anatomical structures, alleviating the superimposition effect [13]. More recent studies indicate about 30% increased DBT sensitivity and specificity compared with DM [14], with a 40% reduction in callback in screening [15-18]. DBT has been implemented in Kuwait during the last 5 years.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Digital Breast Tomosynthesis and Digital Mammography for Detection of Breast Cancer in Kuwaiti Women

et al. 2018

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Objective: To investigate the sensitivity and specificity of digital mammography (DM) and digital breast tomosynthesis (DBT) for the detection of breast cancer in comparison to histopathology findings. Subjects and Methods: We included 65 breast lesions in 58 women, each detected by two diagnostic mammography techniques – DM and DBT using Senographe Essential (GE Healthcare, Buc, France) – and subsequently confirmed by histopathology. The Breast Imaging Reporting and Data System was used for characterizing the lesions. Results: The average age of women was 48.3 years (range 26–81 years). There were 34 malignant and 31 benign breast lesions. The sensitivity of DM and DBT was 73.5 and 100%, respectively, while the specificity was 67.7 and 94%, respectively. Receiver operating characteristic curve analysis showed an overall diagnostic advantage of DBT over DM, with a significant difference between DBT and DM (p < 0.001). By performing Cohen’s kappa test, we found that there was a strong level of agreement according to Altman guidelines between DBT and histopathology findings (0.97), but a weak agreement between DM and histopathology findings (0.47). Conclusion: DBT improves the clinical accuracy of mammography by increasing both sensitivity and specificity. We believe that this improvement is due to improved image visibility and quality. These results could be of interest to health care institutions as they may impact their decision on whether to upgrade to DBT not only for diagnosis, but also for screening.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Digital Breast Tomosynthesis and Digital Mammography for Detection of Breast Cancer in Kuwaiti Women

et al. 2018

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“…There have been a few reader studies and limited prospective studies that compared the performance of s2D mammography versus digital mammography/DBT in a clinical setting (11)(12)(13)(14)(15). Results were mixed: two prospective studies and one reader study showed similar performance between both combination modalities (11,(13)(14)(15), whereas another reader study showed lower sensitivity and comparable specificity in s2D mammography and DBT (referred to as s2D/DBT) versus digital mammography/DBT. In one prospective study, symptomatic patients were included in the s2D mammography and digital mammography/DBT screening group so this cohort was not a true screening population (11).…”

Section: Patient Datamentioning

confidence: 99%

“…BREAST IMAGING: Implementation of Synthesized Two-dimensional Mammography Zuckerman et al interpretation, which may have led to a selection bias (14,15). The purpose of our study was to evaluate the early implementation of s2D mammography in a population screened entirely with s2D/DBT and compare recall rates and cancer detection rates to historic outcomes of digital mammography/DBT screening.…”

mentioning

confidence: 99%

Implementation of Synthesized Two-dimensional Mammography in a Population-based Digital Breast Tomosynthesis Screening Program

Zuckerman¹,

Conant²,

Keller³

et al. 2016

Radiology

130

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Purpose:To evaluate the early implementation of synthesized two-dimensional (s2D) mammography in a population screened entirely with s2D and digital breast tomosynthesis (DBT) (referred to as s2D/DBT) and compare recall rates and cancer detection rates to historic outcomes of digital mammography combined with DBT (referred to as digital mammography/DBT) screening. Materials and Methods:This was an institutional review board-approved and HIPAA-compliant retrospective interpretation of prospectively acquired data with waiver of informed consent. Compared were recall rates, biopsy rates, cancer detection rates, and radiation dose for 15 571 women screened with digital mammography/DBT from October 1, 2011, to February 28, 2013, and 5366 women screened with s2D/ DBT from January 7, 2015, to June 30, 2015. Two-sample z tests of equal proportions were used to determine statistical significance. Results:Recall rate for s2D/DBT versus digital mammography/ DBT was 7.1% versus 8.8%, respectively (P , .001). Biopsy rate for s2D/DBT versus digital mammography/ DBT decreased (1.3% vs 2.0%, respectively; P = .001).There was no significant difference in cancer detection rate for s2D/DBT versus digital mammography/DBT (5.03 of 1000 vs 5.45 of 1000, respectively; P = .72). The average glandular dose was 39% lower in s2D/DBT versus digital mammography/DBT (4.88 mGy vs 7.97 mGy, respectively; P , .001). Conclusion:Screening with s2D/DBT in a large urban practice resulted in similar outcomes compared with digital mammography/DBT imaging. Screening with s2D/DBT allowed for the benefits of DBT with a decrease in radiation dose compared with digital mammography/DBT.q RSNA, 2016

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“…The results indicated 55, 48 and 30% improvement in true positive detection when a 2D-3D setup was used in lieu of traditional setup in Houston, STORM, and Oslo studies, severally [48]. In TOMMY trial in UK, 2015, increased specificity (by 9%) for all studied groups and elevated sensitivity (by 7%) for dense breasts was observed as a result of using digital and film screening [49]. A 2016 review also reported fewer recall rates using the DBT [50].…”

Section: Digital Breast Tomosynthesis (Dbt)mentioning

confidence: 95%

Near-Field Radar Microwave Imaging as an Add-on Modality to Mammography

Ghanbarzadeh-Dagheyan¹,

Molaei²,

Obermeier³

et al. 2017

New Perspectives in Breast Imaging

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According to global statistics, there is a high incidence of cancer in western countries; and, due to the limited resources available in most health care systems, it seems like one of the most feasible options to fight against cancer might be strict prevention policiessuch as eliminating carcinogens in people's daily lives. Nevertheless, early cancer detection and effective treatment are still necessary, and understanding their efficacy and limitations are important issues that need to be addressed in order to ultimately enhance patients' survival rate. In the case of breast cancer, some of the problems faced by conventional mammography have been addressed in the literature; they include high rate of false-positive and false-negative results, as well as the possibility of overdiagnosis. New technologies, such as digital breast tomosynthesis (DBT), have been able to improve the sensitivity and specificity by using 3D imaging. However, the low contrast (1%) existing between tumors and healthy fibroglandular tissue at X-ray frequencies has been identified as one of the main causes of misdiagnosis in both conventional 2D mammography and DBT. Near-field radar imaging (NRI) provides a unique opportunity to overcome this problem, since the contrast existing between the aforementioned tissues is intrinsically higher (10%) at microwave frequencies. Moreover, the low resolution and highly complex scattering patterns of microwave systems can be enhanced by using prior information from other modalities, such as the DBT. Therefore, a multimodal DBT/NRI imaging system is proposed to exploit their individual strengths while minimizing their weaknesses. In this work, the foundation of this idea is reviewed, and a preliminary design and experimental validation of the NRI system, used as a DBT complement, is introduced.

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Accuracy of Digital Breast Tomosynthesis for Depicting Breast Cancer Subgroups in a UK Retrospective Reading Study (TOMMY Trial)

Cited by 157 publications

References 30 publications

Comparison of Digital Breast Tomosynthesis and Digital Mammography for Detection of Breast Cancer in Kuwaiti Women

Comparison of Digital Breast Tomosynthesis and Digital Mammography for Detection of Breast Cancer in Kuwaiti Women

Implementation of Synthesized Two-dimensional Mammography in a Population-based Digital Breast Tomosynthesis Screening Program

Near-Field Radar Microwave Imaging as an Add-on Modality to Mammography

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