Accuracy of day 3 criteria for selecting the best embryos

Milki, Amin A.; Hinckley, Mary D; Gebhardt, J.; Dasig, D.; Westphal, Lynn M.; Behr, Barry

doi:10.1016/s0015-0282(02)03104-7

Cited by 75 publications

(35 citation statements)

References 18 publications

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“…However, it would be difficult to accurately select cleavagestage embryos with the highest implantation potential for ET [23]. On the other hand, some researchers have suggested that blastocyst results in improved selection of developmentally competent embryos compared to cleavage stage embryo, because embryonic genome activation occurs, and embryos with genetic abnormalities have difficulty developing to the blastocyst stage during extended culture [18,24].…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes of elective single morula embryo transfer versus elective single blastocyst embryo transfer in IVF-ET

Kang

Lee

Jeong

et al. 2012

J Assist Reprod Genet

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Purpose To compare the clinical outcomes of elective single morula embryo transfer (eSMET) versus elective single blastocyst embryo transfer (eSBET) in selected patients. Methods This study was a retrospective study which analyzed for 271 cycles in women under 37 years of age who are undergoing their first or second trial of in vitro fertilization-embryo transfer (IVF-ET) from January 2008 to December 2009. The eSMET was performed on day 4 (n0130) and the eSBET was conducted on day 5 (n0141). Results The clinical pregnancy rate (51.5% vs. 51.8%, p0 0.97), implantation rate (52.3% vs. 52.5%, p00.98), and live birth rate (39.2% vs. 44.7%, p00.36) were similar in the eSMET and eSBET groups, respectively. The miscarriage rate of the eSMET group (23.9%) was slightly higher than that of the eSBET group (13.7%) (p00.12), without reaching statistical significance. There was only one case of monozygotic twin pregnancy in each group. ConclusionsThe clinical outcomes of day 4 eSMET were comparable to those of day 5 eSBET. Therefore, day 4 eSMET is a viable option or an alternative to day 5 eSBET, with no difference in success rates.

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Section: Discussionmentioning

confidence: 99%

Clinical outcomes of elective single morula embryo transfer versus elective single blastocyst embryo transfer in IVF-ET

Kang

Lee

Jeong

et al. 2012

J Assist Reprod Genet

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“…Embryo selection criteria based on routine assessment of embryo morphology are not always associated with a higher implantation rate or pregnancy rate [16][17][18]. Therefore, other criteria should be considered in the identification of embryos with a good prognosis for implantation or pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the safety of time-lapse observations for human embryos

Nakahara

Iwase

Goto

et al. 2010

J Assist Reprod Genet

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Purpose To assess the effects of light from an integrated optical microscope and evaluate the safety of time-lapse observations using a built-in microscope incubator. Methods We prospectively compared the fertilization rate and embryonic morphology after intracytoplasmic sperm injection between embryos cultured with time-lapse observations every 15 min in an incubator with an integrated optical microscope and embryos with intermittent observations (once a day) in conventional incubators. Results No significant differences were observed in the fertilization rate (57.5% vs. 57.5%) or the rate of excellentgood cleavage embryos (36.0% vs. 36.0%). Conclusions These results suggest that time-lapse observations using an incubator with an integrated optical microscope may therefore be safely utilized in clinical practice.

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“…Although cell number and fragmentation are the standard means for evaluating embryos, they do not always correlate with implantation potential. [12] We may be missing important comparative data by only using these qualitative descriptions. Therefore, it is still possible the oocyte and embryo quality are different after surgical treatment of endometriosis, but our ability to detect and measure that quality is our limiting factor.…”

Section: Discussionmentioning

confidence: 99%