Accuracy of B-mode ultrasound and ARFI elastography in predicting malignancy of canine splenic lesions

Maronezi, Marjury Cristina; Carneiro, Rafael Kretzer; Cruz, Igor Cezar Kniphoff da; Oliveira, Ana Paula Luiz de; Nardi, Andrígo Barboza De; Pavan, Letícia; Silva, Priscila Del Aguila da; Uscátegui, Ricardo Andrés Ramírez; Feliciano, M. A. R.

doi:10.1038/s41598-022-08317-7

Cited by 5 publications

(5 citation statements)

References 31 publications

(33 reference statements)

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“…ARFI elastography has provided important information about the morphostructural behavior of tissues, making it possible to differentiate healthy structures from diseased ones in dogs through variations in tissue stiffness [18][19][20]. Although this study failed to obtain diagnostic results with elastography for CHD in joint and periarticular structures, it was possible to identify changes in the elasticity of the pectineus musculature between healthy and sick young animals.…”

Section: Discussionmentioning

confidence: 96%

“…Acoustic radiation force impulse (ARFI) elastography is an ultrasonographic technique that allows for quantitative and qualitative measurement of changes in tissue stiffness [18][19][20] by evaluating deformation according to Hooke's law. In general, elastography can be used to differentiate affected tissue (with morphostructural alterations) from normal tissue [21].…”

Section: Introductionmentioning

confidence: 99%

“…In general, elastography can be used to differentiate affected tissue (with morphostructural alterations) from normal tissue [21]. This technique has been explored for several clinical purposes and introduced into medical diagnostic routines for speci c uses, such as the evaluation of liver transplantation in humans [22], splenic alterations [20], and characterization of mammary lesions in dogs [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Accuracy of B-mode ultrasonography and ARFI elastography in the evaluation of the hip joint and hip musculature for the early and late diagnosis of hip dysplasia in dogs

Carneiro

Cruz

Gasser

et al. 2022

Preprint

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Background: Canine hip dysplasia is common orthopedic disease in veterinary, characterized by hip instability in puppies and secondary degenerative joint disease in adult. Radiographic examination has been the main diagnostic method of hip dysplasia. Different radiographic studies, in addition to diagnosing joint laxity and degenerative joint disease, facilitate patient screening and selection of optimal treatment. However, radiographs do not allow for the assessment of capsular characteristics and adjacent muscles, which can be thoroughly evaluated using various ultrasound techniques. Radiographic examinations require anesthetic management, often causing discomfort in the patients and an inconvenience to owners. This study aimed to evaluate the accuracy of B-mode ultrasonography and acoustic radiation force impulse elastography in the evaluation of the joint capsule and periarticular musculature of dogs using the classification of the Orthopedic Foundation of Animals (OFA) and the distraction index (DI) in the early and late diagnosis of hip dysplasia. This study sought to propose a protocol for the ultrasonographic evaluation of the structures involved in canine hip movement. Results: Radiographic and ultrasonographic evaluations were performed on 108 hip joints of 54 dogs. Thirty dogs were older than 2 years and 24 were aged between 4 and 10 months. It was verified that an increase in pectineus muscle stiffness (cutoff value >2.77 m/s) by elastography and an increase in the thickness of the joint capsule (cutoff value >0.9 mm) in B-mode ultrasonography, were associated with a distraction index >0.5, with both having a positive correlation. In B-mode ultrasonographic evaluation, the presence of signs of degenerative joint disease, such as irregularities of the cranial edge of the acetabulum and femoral head, were associated with a distraction index >0.5 in canines, with a specificity of 94%. In adult dogs, the findings of degenerative joint disease on ultrasound were associated with a diseased OFA classification (P<0.05). Measurement of the joint capsule >1.10 mm was diagnostic for dysplasia in unhealthy dogs by OFA. Conclusions: Ultrasound can be used as an adjuvant diagnostic modality in the diagnosis of hip dysplasia in association with radiographic evaluation in young and adult animals.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Accuracy of B-mode ultrasonography and ARFI elastography in the evaluation of the hip joint and hip musculature for the early and late diagnosis of hip dysplasia in dogs

Carneiro

Cruz

Gasser

et al. 2022

Preprint

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“…Ultrasonographic evaluation of the abdominal cavity aims to look for peritoneal effusion, presence and characterization of nodules in the spleen and liver, and search for metastasis in adjacent organs [ 109 , 111 , 112 ]. The characterization of splenic tumors is based on their size, echogenicity, and number of nodules, as well as the presence or absence of cavitation.…”

Section: Diagnosis and Stagingmentioning

confidence: 99%

“…Elastography, which evaluates tissue stiffness using ultrasound, can also enhance B-mode study. Maronezi et al (2022) [ 112 ] achieved an accuracy of 97% for differentiating malignant lesions, and the higher occurrence of malignancy was attributed to the diagnosis of hemangiosarcoma. Malignant lesions are more rigid than benign ones, verifying this characteristic in the elastogram and values greater than 2.6 m/s for shear velocity.…”

Section: Diagnosis and Stagingmentioning

confidence: 99%

Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET

Nardi

Massoco

Fonseca-Alves

et al. 2023

Cancers

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Hemangiosarcoma is a mesenchymal neoplasm originating in the endothelial cells of blood vessels; they can be classified as non-visceral and visceral types. Non-visceral hemangiosarcomas can affect the skin, subcutaneous tissues, and muscle tissues; visceral hemangiosarcomas can affect the spleen, liver, heart, lungs, kidneys, oral cavity, bones, bladder, uterus, tongue, and retroperitoneum. Among domestic species, dogs are most affected by cutaneous HSA. Cutaneous HSA represents approximately 14% of all HSA diagnosed in this species and less than 5% of dermal tumors, according to North American studies. However, Brazilian epidemiological data demonstrate a higher prevalence, which may represent 27 to 80% of all canine HSAs and 13.9% of all skin neoplasms diagnosed in this species. Cutaneous HSA most commonly affects middle-aged to elderly dogs (between 8 and 15 years old), with no gender predisposition for either the actinic or non-actinic forms. The higher prevalence of cutaneous HSA in some canine breeds is related to lower protection from solar radiation, as low skin pigmentation and hair coverage lead to greater sun exposure. Actinic changes, such as solar dermatosis, are frequent in these patients, confirming the influence of solar radiation on the development of this neoplasm. There are multiple clinical manifestations of hemangiosarcoma in canines. The diagnostic approach and staging classification of cutaneous HSAs are similar between the different subtypes. The definitive diagnosis is obtained through histopathological analysis of incisional or excisional biopsies. Cytology can be used as a presurgical screening test; however, it has little diagnostic utility in cases of HSA because there is a high risk of blood contamination and sample hemodilution. Surgery is generally the treatment of choice for dogs with localized non-visceral HSA without evidence of metastatic disease. Recently, electrochemotherapy (ECT) has emerged as an alternative therapy for the local ablative treatment of different neoplastic types; the use of radiotherapy for the treatment of dogs with cutaneous HSA is uncommon. There is greater consensus in the literature regarding the indications for adjuvant chemotherapy in subcutaneous and muscular HSA; doxorubicin is the most frequently used antineoplastic agent for subcutaneous and muscular subtypes and can be administered alone or in combination with other drugs. Other therapies include antiangiogenic therapy, photodynamic therapy, the association of chemotherapy with the metronomic dose, targeted therapies, and natural products. The benefits of these therapies are presented and discussed. In general, the prognosis of splenic and cardiac HSA is unfavorable. As a challenging neoplasm, studies of new protocols and treatment modalities are necessary to control this aggressive disease.

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B-mode ultrasonography and ARFI elastography of articular and peri-articular structures of the hip joint in non-dysplastic and dysplastic dogs as confirmed by radiographic examination

Carneiro,

da Cruz,

Gasser

et al. 2023

BMC Vet Res

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Background Canine hip dysplasia is a common orthopedic disease in veterinary practice. The diagnosis is made by radiographic examinations that evaluate bone alterations associated with hip dysplasia. Although radiographic examination is the gold standard for diagnosis, it does not allow a detailed evaluation of soft tissues such as the joint capsule and periarticular muscles. This study aimed to evaluate the accuracy of B-mode ultrasonography and acoustic radiation force impulse (ARFI) elastography in assessing the joint capsule and periarticular muscles of dogs using the Orthopedic Foundation of Animals (OFA) classification and the distraction index (DI) in the early and late diagnosis of hip dysplasia. This study sought to propose a protocol for the ultrasonographic evaluation of the structures involved in canine hip dysplasia. Methods Radiographic and ultrasonographic evaluations were performed on 108 hip joints of 54 dogs. Thirty dogs were older than 2 years and 24 were aged between 4 and 10 months. Results It was verified that an increase in pectineus muscle stiffness (cutoff value > 2.77 m/s) by elastography in some dysplastic dogs and an increase in the thickness of the joint capsule (cutoff value > 0.9 mm) in B-mode ultrasonography, were associated with a distraction index > 0.5, with both having a positive correlation. In B-mode ultrasonographic evaluation, the presence of signs of degenerative joint disease, such as irregularities of the cranial edge of the acetabulum and femoral head, were associated with a distraction index > 0.5 in canines, with a specificity of 94%. In adult dogs, the findings of degenerative joint disease on ultrasound were associated with a diseased OFA classification (P < 0.05). Measurement of the joint capsule > 1.10 mm was diagnostic for dysplasia in unhealthy dogs by OFA. Conclusions ARFI elastography has shown that the pectineus muscle may experience changes in stiffness in dysplastic animals. Additionally, changes in joint capsule thickness can be identified in B-mode in young and adult dogs with dysplastic joints, which contributes to the diagnosis of hip dysplasia.

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Accuracy of B-mode ultrasound and ARFI elastography in predicting malignancy of canine splenic lesions

Cited by 5 publications

References 31 publications

Accuracy of B-mode ultrasonography and ARFI elastography in the evaluation of the hip joint and hip musculature for the early and late diagnosis of hip dysplasia in dogs

Accuracy of B-mode ultrasonography and ARFI elastography in the evaluation of the hip joint and hip musculature for the early and late diagnosis of hip dysplasia in dogs

Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET

B-mode ultrasonography and ARFI elastography of articular and peri-articular structures of the hip joint in non-dysplastic and dysplastic dogs as confirmed by radiographic examination

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