Accuracy of 18 F-FDG PET/CT in Detection of Neck Metastases of Oral Squamous Cell Carcinoma in Patients Without Large Palpable Lymph Nodes

Niu, Lixuan; Zheng, Dong; Wang, Diancan; Zhang, Jianyun; Fei, Jun; Guo, Chao

doi:10.1016/j.oooo.2019.09.005

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…PET/CT was found invalid if the lesion was smaller than 5 mm. Furthermore, some occult nodal metastases harbored a small amount of 18F-FDG uptake, while some inflammatory LNs or LNs close to the submandibular gland may got relative higher value of nodal SUVmax [ 19 ]. Therefore, nodal SUVmax should not be the sole criterion for predicting the presence of neck metastasis.…”

Section: Discussionmentioning

confidence: 99%

A prediction model of nodal metastasis in cN0 oral squamous cell carcinoma using metabolic and pathological variables

Peng

Feng

et al. 2023

Cancer Imaging

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Background The efficacy of 18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography/Computed Tomography(PET/CT) in evaluating the neck status in clinically node-negative (cN0) oral squamous cell carcinoma(OSCC) patients was still unsatisfying. We tried to develop a prediction model for nodal metastasis in cN0 OSCC patients by using metabolic and pathological variables. Methods Consecutive cN0 OSCC patients with preoperative 18F-FDG PET/CT, subsequent surgical resection of primary tumor and neck dissection were included. Ninety-five patients who underwent PET/CT scanning in Shanghai ninth people’s hospital were identified as training cohort, and another 46 patients who imaged in Shanghai Universal Medical Imaging Diagnostic Center were selected as validation cohort. Nodal-status-related variables in the training cohort were selected by multivariable regression after using the least absolute shrinkage and selection operator (LASSO). A nomogram was constructed with significant variables for the risk prediction of nodal metastasis. Finally, nomogram performance was determined by its discrimination, calibration, and clinical usefulness. Results Nodal maximum standardized uptake value(nodal SUVmax) and pathological T stage were selected as significant variables. A prediction model incorporating the two variables was used to plot a nomogram. The area under the curve was 0.871(Standard Error [SE], 0.035; 95% Confidence Interval [CI], 0.787–0.931) in the training cohort, and 0.809(SE, 0.069; 95% CI, 0.666–0.910) in the validation cohort, with good calibration demonstrated. Conclusions A prediction model incorporates metabolic and pathological variables has good performance for predicting nodal metastasis in cN0 OSCC patients. However, further studies with large populations are needed to verify our findings.

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Section: Discussionmentioning

confidence: 99%

A prediction model of nodal metastasis in cN0 oral squamous cell carcinoma using metabolic and pathological variables

Peng

Feng

et al. 2023

Cancer Imaging

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“…Our decision to include PET/CT in this study despite these perceived disadvantages was based on the fact that this modality is already widely employed in oral cavity SCC based on its effectiveness in detecting nodal involvement [ 19 ], as well as its superiority to CT and MRI in this regard [ 20 ]. PET/CT is also useful in measuring tumor volume [ 21 ], detecting the presence of bone invasion [ 13 , 22 ], and assessing the response to neoadjuvant and definitive chemoradiation [ 23 ], all of which suggest that it could be used to assess DOI.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Determination of Depth of Invasion in Oral Cavity Squamous Cell Carcinoma by Standard Cross-Sectional Imaging With Computed Tomography and Positron Emission Tomography/Computed Tomography

Naha¹,

Biedermann²,

Nada³

et al. 2023

Cureus

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BackgroundDepth of invasion (DOI) is a known indicator of metastatic potential in oral cavity squamous cell carcinoma (SCC). Our purpose was to investigate the accuracy of preoperative determination of DOI in oral cavity SCC by computed tomography (CT) and positron emission tomography/computed tomography (PET/CT). MethodologyA retrospective study was performed using consecutive patients with histologically proven oral cavity SCC presenting to our otorhinolaryngology department between January 2014 and July 2019 who underwent preoperative contrast-enhanced CT and/or PET/CT. Pathological assessment of DOI was determined by a review of pathology reports. The degree of DOI determined by radiographic studies was correlated to pathology results. ResultsA total of 79 patients were screened of whom appropriate radiographic studies were available for 63 patients. The mean DOI by pathological assessment was 12.3 ± 9.1 mm. CT and PET/CT determined depth both correlated with pathological DOI (r = 0.710; p < 0.001, r = 0.798; p < 0.001). No significant correlation was seen for CT-determined depth (r = 0.136; p = 0.709) or PET-determined depth (r = 0.234; p = 0.707) with pathologically confirmed superficial tumors (<5 mm). For patients with pathological tumor depth >10 mm, CT and PET determined depth both correlated with pathological depth (r = 0.577; p = 0.002, r = 0.668; p = 0.001). The sensitivity and specificity of CT and PET for the identification of deep invasion were 88.2% and 41.7% and 52.9% and 50%, respectively. ConclusionsDOI measurement is feasible with routine preoperative CT and PET/CT images and is comparable to pathological measurement in patients with oral cavity SCC.

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“…There have been various reports on the diagnostic of lymph node metastasis, including patient-based [7,8,12], left-/right-based [7,8,17], region-level-based [7][8][9]13,16,17,22], and lymph node-based methods [12,14,15,[18][19][20]22,[24][25][26][27]. Lymph node-based methods of study appear to be the most accurate techniques for evaluating the diagnostic accuracy of each diagnostic imaging modality.…”

Section: Discussionmentioning

confidence: 99%

Comparing the Diagnostic Accuracy of Ultrasonography, CT, MRI, and PET/CT in Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma

Takamura,

Nikkuni,

Hayashi

et al. 2023

Biomedicines

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(1) Background: In oral cancer staging, ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) with positron emission tomography/computed tomography (PET/CT) are routinely used in clinical practice. The present study is a retrospective examination of the diagnostic accuracy of cervical lymph node metastasis using US, CT, MRI, and PET/CT, with histopathological diagnosis as a reference, to compare the different diagnostic imaging modalities. (2) Methods: The participants included 16 patients with oral squamous cell carcinoma who underwent US-, CT-, MRI-, and PET/CT-based preoperative diagnostic imaging and simultaneous primary lesion resection and neck dissection, including 82 level regions and 424 lymph nodes. We compared the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of each imaging modality based on the imaging results and the pathology results of metastasis. (3) Results: Of the four diagnostic imaging modalities, PET/CT exhibited the highest sensitivity but the lowest specificity and accuracy. US, CT, and MRI had high specificities. Comparing each level region and lymph node showed that differences were observed in PET/CT. (4) Conclusions: PET/CT to diagnose lymph node metastasis requires a comprehensive evaluation because it produces more false positives than other diagnostic imaging modalities. Using US, CT, and MRI, which have excellent spatial resolution, improves diagnostic accuracy at the lymph node level.

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Accuracy of 18 F-FDG PET/CT in Detection of Neck Metastases of Oral Squamous Cell Carcinoma in Patients Without Large Palpable Lymph Nodes

Cited by 9 publications

References 25 publications

A prediction model of nodal metastasis in cN0 oral squamous cell carcinoma using metabolic and pathological variables

A prediction model of nodal metastasis in cN0 oral squamous cell carcinoma using metabolic and pathological variables

Preoperative Determination of Depth of Invasion in Oral Cavity Squamous Cell Carcinoma by Standard Cross-Sectional Imaging With Computed Tomography and Positron Emission Tomography/Computed Tomography

Comparing the Diagnostic Accuracy of Ultrasonography, CT, MRI, and PET/CT in Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma

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