Accumulation of virulence-associated proteins in Campylobacter jejuni Outer Membrane Vesicles at human body temperature

Biofilm formation and extracellular microvesicles—The way of foodborne pathogens toward resistance

“…The human and avian hosts are different in many aspects, like body temperature (∼37 and ∼42°C in birds). This food pathogen adapts to different temperatures of host bodies, and different temperatures seem to activate processes that are related to the pathogenesis of this bacterium [176]. Both bacterial transcriptome and proteome are different after growing at different temperatures [176][177][178][179].…”

“…This food pathogen adapts to different temperatures of host bodies, and different temperatures seem to activate processes that are related to the pathogenesis of this bacterium [176]. Both bacterial transcriptome and proteome are different after growing at different temperatures [176][177][178][179]. Campylobacter jejuni delivers virulence proteins by flagella [180], but this bacterium also uses MVs as another delivery system for infection of host cells by virulence factors [176,181,182].…”

“…Both bacterial transcriptome and proteome are different after growing at different temperatures [176][177][178][179]. Campylobacter jejuni delivers virulence proteins by flagella [180], but this bacterium also uses MVs as another delivery system for infection of host cells by virulence factors [176,181,182]. Proteomics analyses have demonstrated that C. jejuni MVs contain proteins from the periplasm, outer membrane-associated proteins, as well as cytoplasmic proteins that are essential for both survival and pathogenesis of this foodborne bacterium [176,177,183].…”

“…Campylobacter jejuni delivers virulence proteins by flagella [180], but this bacterium also uses MVs as another delivery system for infection of host cells by virulence factors [176,181,182]. Proteomics analyses have demonstrated that C. jejuni MVs contain proteins from the periplasm, outer membrane-associated proteins, as well as cytoplasmic proteins that are essential for both survival and pathogenesis of this foodborne bacterium [176,177,183]. Cleavage of host cells' proteins E-cadherin and occludin enhance bacterial invasion into host epithelial cells [181,182], and MVs isolated from in vitro bile treated bacteria also enhance this process [184].…”

“…Cleavage of host cells' proteins E-cadherin and occludin enhance bacterial invasion into host epithelial cells [181,182], and MVs isolated from in vitro bile treated bacteria also enhance this process [184]. According to Taheri et al [176] composition of the C. jejuni MVs depends on growth temperature and it has implications for the outcome of colonization and pathogenicity of this bacterium in different hosts. Elmi et al [185] indirectly confirmed the abovementioned findings by Taheri et al [184] using bile salt sodium taurocholate.…”