2001
DOI: 10.5414/cpp39389
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Accumulation of fluconazole in sebum

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Cited by 4 publications
(3 citation statements)
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“…However, it does not follow that this drug will fail, provided those concentrations can be exceeded at the site of infection. In this regard, data obtained in humans are encouraging [98,99], with levels in the stratum corneum potentially exceeding most of the MICs obtained for FCZ against M. pachydermatis in studies employing the MIC 50 /MIC 90 rule. Though it has been hypothesised that FCZ also accumulates in the stratum corneum of dogs [14]-with peak plasma levels of approximately 10 µg/mL following a 10 mg/kg dose [100]-we cannot know for sure whether this accumulation is of the same entity as that shown in humans.…”
Section: Interpretation Based On Mic 50 /Mic 90 Valuesmentioning
confidence: 90%
“…However, it does not follow that this drug will fail, provided those concentrations can be exceeded at the site of infection. In this regard, data obtained in humans are encouraging [98,99], with levels in the stratum corneum potentially exceeding most of the MICs obtained for FCZ against M. pachydermatis in studies employing the MIC 50 /MIC 90 rule. Though it has been hypothesised that FCZ also accumulates in the stratum corneum of dogs [14]-with peak plasma levels of approximately 10 µg/mL following a 10 mg/kg dose [100]-we cannot know for sure whether this accumulation is of the same entity as that shown in humans.…”
Section: Interpretation Based On Mic 50 /Mic 90 Valuesmentioning
confidence: 90%
“…These are now almost completely replaced by the ''sebutape'', a lipid-adsorbing polymeric film which is firmly sealed for some hours to the skin area under investigation [17]. Subsequently, the adsorbed lipids can be eluted and analysed for the lipid composition or the presence of vitamins or drugs [21][22][23][24][25][26].…”
Section: Introductionmentioning
confidence: 99%
“…The excretion of organic pollutants in sebum has received only limited study [3]. Based on studies already done, we can see that sebum is a promising matrix to diagnose exposure to a wide range of exogenous substances like codeine and cocaine [14], fluconazole [15] and dioxins [16]. Considering the liphophilicity of some semi volatile organic pollutants, it seems likely that their secretion in sebum could represent an important route for their elimination from the body.…”
Section: Introductionmentioning
confidence: 99%