Accumulation of Endosulfan in Wild Rat, Rattus norvegious as a Result of Application to Soya Bean in Mazoe (Zimbabwe)

Kuvarega, Alex T.; Taru, Philip

doi:10.1007/s10661-006-9526-9

Cited by 12 publications

(5 citation statements)

References 21 publications

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“…Chromatography analysis showed concentration of endosulfan accumulated in the liver and adipose tissue from EDS1 and EDS2 bats. Similar concentrations of endosulfan were found in the liver and adipose tissue of Rattus norvegicus collected in soya bean farm areas (Kuvarega & Taru ). These results show that even at low doses, EDS may accumulate in the tissue and is likely to cause injuries by changing the organ function (Raj et al .…”

Section: Discussionsupporting

confidence: 67%

Exposure to the insecticide endosulfan induces liver morphology alterations and oxidative stress in fruit‐eating bats (Artibeus lituratus)

Oliveira

Brinati

Miranda

et al. 2017

Int J Experimental Path

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Exposure to pesticides may increase the generation of reactive oxygen species (ROS), leading to oxidation of cell membrane lipids and proteins. Although fruit bats are potentially exposed to pesticides during their entire lifespan, the impacts of this exposure are still poorly investigated. We examined the effects of low, commercially recommended concentrations (0, 1.05 and 2.1 g/l) of an organochlorine insecticide endosulfan (EDS) formulation on oxidative responses in the liver and kidneys of Neotropical fruit bats (Artibeus lituratus), as well as possible liver morphological alterations following a 35-day oral exposure. Superoxide dismutase activity was significantly decreased upon exposure to 1.05 g/l of EDS in the liver and kidneys, catalase was decreased in the liver of 2.1 g/l EDS-exposed bats, while glutathione S-transferase was increased in the liver of 2.1 g/l EDS-exposed bats. Protein carbonyls increased following the exposure to the highest EDS dose tested. Endosulfan-induced morphological alterations in the liver included cell degeneration and cell death, with apparent cytoplasm lipid accumulation (steatosis) and pyknotic nuclei, karyolysis and deposit of collagen fibres. Our findings suggest that exposure to low concentrations of EDS induced a certain extent of oxidative damage in fruit bats, which may have led to liver morphological alterations.

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Section: Discussionsupporting

confidence: 67%

Exposure to the insecticide endosulfan induces liver morphology alterations and oxidative stress in fruit‐eating bats (Artibeus lituratus)

Oliveira

Brinati

Miranda

et al. 2017

Int J Experimental Path

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“…In mammals, endosulfan is accumulated in livers, muscles, brain and fatty tissues of animals (Kuvarega and Taru, ). Endosulfan was detected in placenta, cord blood, and milk of fertile women (Cerrillo et al, ).…”

Section: Introductionmentioning

confidence: 99%

Isomers and their metabolites of endosulfan induced cytotoxicity and oxidative damage in SH-SY5Y cells

et al. 2014

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As an organochlorine insecticide, endosulfan has been widely banned or restricted, but it is still largely used in many developing countries. Previous studies have shown multiple adverse health effects of endosulfan. However, the neurotoxicity of endosulfan has not been fully elucidated. In this study, endosulfan isomers (α-/β-endosulfan) and their major metabolites (endosulfan sulfate, endosulfan diol, and endosulfan lactone) were, respectively, exposed to human neuroblastoma SH-SY5Y cells. Results showed that both α-endosulfan and β-endosulfan caused decrease of cell viability and morphological damages in a dose-dependent manner. Their median effective concentrations (EC50s) were respectively 79.6 μM (α-endosulfan) and 50.37 μM (β-endosulfan) for 72 h exposure. EC50s of α/β-endosulfan mixture were lower than that of the single isomer. However, EC50s of its metabolites were higher than that of technical endosulfan. Endosulfan and its metabolites caused increases of reactive oxygen species and the lipid peroxidation, but decrease of superoxide dismutase in a dose-dependent manner. These results indicate that α-endosulfan exhibits higher neurotoxicity than β-endosulfan. Mixture of endosulfan isomers shows stronger cytotoxicity than the single isomer. After endosulfan is degraded, cytotoxicity of its metabolites decreases gradually. The neurotoxicity of endosulfan and its metabolites is closely related to oxidative damage and antioxidative deficit.

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“…There are several reports of endosulfan presence as a residue in significant quantities in soils . It can be seen that unlike accumulation of endosulfan in many mammals like rats where adsorption decreases in a parabolic manner as the concentration of the substance decrease in solution, the bacterial accumulation has not been observed. However, in this study, a significant bacterial accumulation could be observed.…”

Section: Discussionmentioning

confidence: 99%

Effect of Residual Endosulfan on Pseudomonas aeruginosa NCIM 2036

Patil

Niljikar

Ghosh

2014

CLEAN Soil Air Water

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Endosulfan has been banned in several developed nations; it is still the farmers’ favorite in many developing nations. The farmers use this pesticide indiscriminately resulting in high residues in soil. The objective of this investigation is not to reestablish the findings of other researchers regarding the residual endosulfan quantity in different agricultural soils of this country; neither is it aimed to find out the biodegradative mechanism of the compound by microorganisms. The investigation aims at studying the biomagnification carried out by a heterotrophic soil organism: Pseudomonas aeruginosa NCIM 2036. The pesticide has been found inside the microorganism resulting in longer lag phase of growth of the organisms which ultimately has deleterious effect on mineral cycling in soil, affecting crop yield.

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Accumulation of Endosulfan in Wild Rat, Rattus norvegious as a Result of Application to Soya Bean in Mazoe (Zimbabwe)

Cited by 12 publications

References 21 publications

Exposure to the insecticide endosulfan induces liver morphology alterations and oxidative stress in fruit‐eating bats (Artibeus lituratus)

Exposure to the insecticide endosulfan induces liver morphology alterations and oxidative stress in fruit‐eating bats (Artibeus lituratus)

Isomers and their metabolites of endosulfan induced cytotoxicity and oxidative damage in SH-SY5Y cells

Effect of Residual Endosulfan on Pseudomonas aeruginosa NCIM 2036

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