Accumulation of collagen in ovarian benign tumours.

Wolańska, Małgorzata; Sobolewski, Krzysztof; Bańkowski, Edward; Drozdzewicz, M

doi:10.18388/abp.1999_4117

Cited by 4 publications

(3 citation statements)

References 18 publications

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Section: Fibrillar Collagensmentioning

confidence: 99%

“…organization and an intensive staining of collagen type III 28,29 and a decrease in collagen type I. 29 Malignant ovarian tumors contain lower levels of total collagen and cross-linked types I and III collagens compared with benign tumors. 30 Despite the lower collagen content in ovarian carcinoma tissue, the synthesis rates of both types I and III collagens are increased as determined by increased procollagen propeptide concentrations.…”

Section: Fibrillar Collagensmentioning

confidence: 99%

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Extracellular Matrix of Ovarian Tumors

Ricciardelli¹,

Rodgers²

2006

Semin Reprod Med

116

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Tumor cells interfere with the normal programming of extracellular matrix (ECM) biosynthesis and can extensively modify the structure and composition of the matrix. The role of ECM components is becoming increasingly recognized as an important determinant for the growth and progression of solid tumors. The extensive remodeling of the normal ECM in tumors can proceed through the degradation of pre-existing ECM molecules and/or by the neosynthesis of ECM components, which in many cases are not present in the ECM of normal tissues. In the ovary the ECM comprises a variety of molecules including the collagen superfamily and noncollagenous proteins such as glycoproteins, proteoglycans, and hyaluronan. Elevated levels of laminin-gamma2, collagen types I and III, fibronectin, syndecan-1, glypican-1, versican, and hyaluronan and its receptors CD44 have all been associated with a poor prognosis of ovarian cancers. Generally, there is a differential expression of laminin chains alpha1, alpha4, and beta2 among serous (alpha1, beta2), mucinous (alpha4), and endometrioid (alpha1) tumors. This review focuses on these and other ECM molecules in ovarian tumors.

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Section: Fibrillar Collagensmentioning

confidence: 99%

Section: Fibrillar Collagensmentioning

confidence: 99%

Extracellular Matrix of Ovarian Tumors

Ricciardelli¹,

Rodgers²

2006

Semin Reprod Med

116

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“…Hyaluronan (HA) is a special class of glycosaminoglycans not bound to a protein core. Normal ovary contains large amounts of DS [11] , [12] , however, during ovarian carcinogenesis the predominant glycosaminoglycan reverts to CS [13] , a phenomenon seen in various types of cancer [14] , [15] . Within the class of CS a large heterogeneity exists due to the presence of differently sulfated disaccharide units including CSA (4-sulfated), CSC (6-sulfated), CSD (2,6-disulfated) and CSE (4,6-disulfated).…”

Section: Introductionmentioning

confidence: 99%

Primary Ovarian Carcinomas and Abdominal Metastasis Contain 4,6-Disulfated Chondroitin Sulfate Rich Regions, Which Provide Adhesive Properties to Tumour Cells

Vallen

Schmidt²,

Oosterhof

et al. 2014

PLoS ONE

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High mortality in ovarian cancer patients is primarily caused through rapid metastasis of the tumour, but the underlying mechanisms are poorly understood. Glycosaminoglycans, are abundantly present in tumours and chondroitin sulfate-E (CSE), a highly 4,6-sulfated glycosaminoglycan, has been indicated to play a role in carcinogenesis. In this study we investigated the presence of CSE in ovarian cancer metastasis and studied its role in tumour cell adhesiveness and migration. CSE was studied immunohistochemically in primary ovarian carcinomas and abdominal metastases using the single chain antibody GD3G7. The role of CSE was studied in 2D (scratch assays) and 3D (collagen matrices, spheroids) systems using SKOV3 cells applying 1: overexpression of CSE by stable transfection with DNA encoding GalNAc4S-6 sulfotransferase, 2: enzymatic removal of CS, and 3: addition of CSE. In ovarian cancer tissue, CSE expression was predominantly seen in the stromal compartment of both primary ovarian carcinomas and metastases, with a comparable degree of intensity and extent. Overexpression of CSE disaccharide units by tumour cells increased their adhesive properties which was especially seen in tumour spheroid formation. Increased expression of CSE reduced cell migration. Addition of free CSE had similar effects. The data presented here indicate that CSE is associated with metastatic lesions and that it provides tumours with adhesive properties. CSE rich motifs are put forward as a potential target for ovarian cancer therapy.

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Identification of human ovarian cancer relying on collagen fiber coverage features by quantitative second harmonic generation imaging

et al. 2022

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Ovarian cancer has the highest mortality rate among all gynecological cancers, containing complicated heterogeneous histotypes, each with different treatment plans and prognoses. The lack of screening test makes new perspectives for the biomarker of ovarian cancer of great significance. As the main component of extracellular matrix, collagen fibers undergo dynamic remodeling caused by neoplastic activity. Second harmonic generation (SHG) enables label-free, non-destructive imaging of collagen fibers with submicron resolution and deep sectioning. In this study, we developed a new metric named local coverage to quantify morphologically localized distribution of collagen fibers and combined it with overall density to characterize 3D SHG images of collagen fibers from normal, benign and malignant human ovarian biopsies. An overall diagnosis accuracy of 96.3% in distinguishing these tissue types made local and overall density signatures a sensitive biomarker of tumor progression. Quantitative, multi-parametric SHG imaging might serve as a potential screening test tool for ovarian cancer.

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Accumulation of collagen in ovarian benign tumours.

Cited by 4 publications

References 18 publications

Extracellular Matrix of Ovarian Tumors

Extracellular Matrix of Ovarian Tumors

Primary Ovarian Carcinomas and Abdominal Metastasis Contain 4,6-Disulfated Chondroitin Sulfate Rich Regions, Which Provide Adhesive Properties to Tumour Cells

Identification of human ovarian cancer relying on collagen fiber coverage features by quantitative second harmonic generation imaging

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