Accumulation and glucocorticoid signaling suppression by four emerging perfluoroethercarboxylic acids based on animal exposure and cell testing

Kynurenic Acid Plays a Protective Role in Hepatotoxicity Induced by HFPO-DA in Male Mice

“…25,28 In another study, low-dose exposure to either HFPO-DA or PFOA for 140 d led to liver enlargement in PFOA-treated mice, while no significant change in liver weight was noted in the HFPO-DA group. 27 In pregnant mice, the impact of 10 mg/kg/d HFPO-DA on liver index and liver function was comparable to that of 5 mg/kg/d PFOA. 30 Exposure to PFAS can affect the concentrations of proteins and metabolites in organisms, 31,32 which may serve as biomarkers for assessing the risks associated with PFAS exposure and diagnosing related diseases.…”

“…Given that the toxicities of per- and polyfluoroalkyl substances (PFAS) are somewhat dependent on their accumulation, HFPO-DA may exhibit lower toxicity compared to PFOA due to its lower accumulation . Similar to PFOA, HFPO-DA exposure can also induce hepatomegaly, elevate liver function indices, and disturb bile acid and fatty acid metabolism in mice. ,, However, HFPO-DA causes less pronounced hepatomegaly and fewer changes in liver function indices in male mice than does PFOA at equivalent doses. , In another study, low-dose exposure to either HFPO-DA or PFOA for 140 d led to liver enlargement in PFOA-treated mice, while no significant change in liver weight was noted in the HFPO-DA group . In pregnant mice, the impact of 10 mg/kg/d HFPO-DA on liver index and liver function was comparable to that of 5 mg/kg/d PFOA …”

“…25 Rice et al reported that the elimination half-life (t 1/2 ) of HFPO-DA in rodents ranged from 3 to 21 h. 26 A recent study also reported that the t 1/2 of HFPO-DA in the serum of male mice exposed to a low dose of HFPO-DA (10 μg/kg) was 12.57 h, which is only one-fiftieth of that observed for PFOA. 27 Given that the toxicities of per-and polyfluoroalkyl substances (PFAS) are somewhat dependent on their accumulation, HFPO-DA may exhibit lower toxicity compared to PFOA due to its lower accumulation. 28 Similar to PFOA, HFPO-DA exposure can also induce hepatomegaly, elevate liver function indices, and disturb bile acid and fatty acid metabolism in mice.…”

Programming of a Portable Digital Monitoring System-Integrated DNA Aptamer Reversely Regulated Oxidase-Like Nanozyme for Real-Time Dynamic Analysis of Atmospheric Perfluorooctanoic Acid

“…5 The long-term exposure to PFOA may cause a range of adverse effects toward human health, including thyroid dysfunction, kidney hypoplasia, inhibition of embryonic development, and even cancer. 6,7 In this background, the production of PFOA has been widely scrutinized from 2019; however, the prohibition of PFOA production has not yet been realized globally, and PFOA has still been prevalent in the ecological environment for many years. 8,9 A currently typical case was known that PFOA could be released directly into the atmosphere through landfills, vehicle exhaust, and wastewater treatment plants, easily interacting with particulate matter in the gas phase to form aerosolized particles that could be transported over long distances and contribute to greater pollution.…”