Kynurenic Acid Plays a Protective Role in Hepatotoxicity Induced by HFPO-DA in Male Mice
Jianglin Hu,
Jiayin Dai,
Nan Sheng
Abstract:Following
its introduction as an alternative to perfluorooctanoic
acid, hexafluoropropylene oxide dimer acid (HFPO-DA) has been extensively
detected in various environmental matrices. Despite this prevalence,
limited information is available regarding its hepatotoxicity biomarkers.
In this study, toxicokinetic simulations indicated that under repeated
treatment, HFPO-DA in mice serum reached a steady state by the 4th
day. To assess its subacute hepatic effects and identify potential
biomarkers, mice were admin… Show more
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