Accumulation and elimination of14C-γ-HCH (lindane) inNereis virens (Polychaeta) with consideration of metabolites

Abstract

In two experiments, conducted at 6 ~ and 16 ~ 43 Nereis virens were exposed to 14Clabelled y-HCH (lindane) at a concentration of 1 pg/1, which was maintained by intermittent monitoring and redosing. A closed system with individuals living in glass tubes was used. At equilibrium and during the subsequent phase of elimination, both ~,-HCH and metabolites were determined in individual worms as well as in the water and faeces throughout the entire experiment. The bioconcentration factors of ?-HCH were 480 and 440 at 6 ~ and 16 ~ respectively; those based on total radioactivity were 500 and 410. These factors were in the upper range of those known for other aquatic animals. The elimination may be described by an exponential function. The initial 50 % decrease of y-HCH and N-HCH + metabolites in the worms occurred at both temperatures in 2 and 3 days, respectively. The percentage of y-HCH metabolites in worms increased considerably during the elimination period. At least four metabolites were detected in worms and water. If pollutants are evaluated by accumulation and elimination kinetics, metabolization has to be taken into account.

Benz(a)anthracene in benthic marine environments : bioavailability, metabolism, and physiological effects on the polychaete Neries virens

“…Rossi and Anderson (1978) reported depuration of metabolized naphthalene was slower than that of the parent compound in the worm Neanthes arenaceodentata. Similar findings have been reported for BP in the blue crab Ca 11 inectes (Lee et a I., 1976) and in three species of fish (Lee et al, 1972b); for naphthalene in the rainbow trout (Varanasi et aI., 1978); and for the chlorinated hydrocarbon lindane in Nereis virens (Goerke and Ernst, 1980).…”

“…They have also shown in vitro metabolism of BP to primarily phenolic and diol metabolites (Fries and Lee, 1984). 1ll vivo metabolism of chlorinated hydrocarbons such as lindane (Goerke and Ernst, 1980) and a pentachlorobiphenyl (Goerke, 1984) has been reported in Nereis virens, but in vivo PAH metabolism has not been investigated. Lee et a 1.…”