Accounting for linkage between the STR loci D5S818/CSF1PO and vWA/D12S391 in kinship analyses: Impact on likelihood ratio values

Burri, Helen; Sulzer, Andrea; Voegeli, P.; Krätzer, A.

doi:10.1016/j.fsigss.2015.09.153

Cited by 3 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The linked SNPs have proved to be very powerful tools for solving distant family relationship . But few closely linked STR markers have been assessed for kinship analysis except for the loci available in commercial STR kits (such as vWA‐D12S391 , D5S818‐CSF1PO, D21S11‐Penta D , and other loci ). Therefore, a multiplex PCR systems with the simultaneous analysis of 13 autosomal STR (AS‐STR) markers including the six clusters of closely linked markers (clusterⅠ: D3S2402‐D3S2452‐D3S1766; Ⅱ: D3S4554‐D3S2388; Ⅲ: D3S3051‐D3S3053; Ⅳ: D4S2364‐D4S2404; Ⅴ: AC001348A‐AC001348B; Ⅵ:D17S975‐D17S1294) was developed to generalize the application of closely linked AS‐STR in forensics .…”

Section: Introductionmentioning

confidence: 99%

“…These show that determination of second‐degrees relatives or more distant family relationship is very difficult on the basis of unlinked autosomal chromosome genetic markers. Fortunately, some potential strategies have been suggested to solve the identification of distant relationships, such as analyzing large numbers of SNP or linked STR markers . The linked SNPs have proved to be very powerful tools for solving distant family relationship .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential of 13 linked autosomal short tandem repeat loci in pairwise kinship analysis

Liu

Xue

et al. 2016

Electrophoresis

View full text Add to dashboard Cite

In this study, a panel of 13 STR loci locate on chromosome 3, 4, and 17 (D3S2402, D3S2452, D3S1766, D3S4554, D3S2388, D3S3051, D3S3053, D4S2404, D4S2364, AC001348A, AC001348B, D17S975, and D17S1294) were assessed for pairwise kinship analysis. Map distances between these STR loci ranged from 0.07 cM to 97.03 cM. The population genetic study of Chinese Han population showed that linkage disequilibrium exists in two clusters of closely linked markers (D4S2404-D4S2364 and D17S975-D17S1294), in which the recombination fractions were 0.0026 and 0.0001, respectively. The recombination fractions derived from the Rutgers Map for the closely linked markers (genetic distance < 0.5 cM) were significant underestimates in comparison to those of direct observation of STR transmissions in families. When effect of linkage on pairwise kinship testing was evaluated by comparing likelihood ratio (LR) values taking linkage into account, overall LR values increased. But extremely low LRs were also observed. Finally, the power of the 13 STR loci to discriminate relationship among full-sibs, half-sibs, grandparent-grandchild, uncle-niece, and unrelated pairs was assessed with a category fraction. The results showed that about 72.64% of full-sib pairs and about 82.84% of unrelated pairs could be classified correctly. But the category fractions of second-degree relationships drastically reduced to 7.34-35.48%. If only pairs of grandparent-grandchild, half-sibs, and uncle-niece were distinguished, the category fraction was 0.5512, 0.1147, and 0.4362, respectively. Our study results demonstrated that linked STRs were helpful to differentiate the most frequent relationships in pairwise kinship analysis.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential of 13 linked autosomal short tandem repeat loci in pairwise kinship analysis

Liu

Xue

et al. 2016

Electrophoresis

View full text Add to dashboard Cite

show abstract

“…In fact, some common markers may not be strictly independent. For example, the short tandem repeat (STR) loci vWA and D12S391 are only ~6.36 million bases (Mb) apart and demonstrate linkage [1].Many studies have been conducted to investigate the dependencies among the common forensic markers, and a number of linked marker pairs have been identified, which can have an impact on statistical calculations [2][3][4][5][6][7][8][9][10][11]. Accordingly, the statistical calculation and interpretation of these dependent markers may need to be adjusted [4,[12][13][14][15].…”

mentioning

confidence: 99%

“…Many studies have been conducted to investigate the dependencies among the common forensic markers, and a number of linked marker pairs have been identified, which can have an impact on statistical calculations [2][3][4][5][6][7][8][9][10][11]. Accordingly, the statistical calculation and interpretation of these dependent markers may need to be adjusted [4,[12][13][14][15].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Linkage and linkage disequilibrium among the markers in the forensic MPS panels

Budowle

Sun

et al. 2021

Journal of Forensic Sciences

View full text Add to dashboard Cite

Since the birth of forensic genetics decades ago, the selected forensic markers typically are assumed to be independent of each other, so that the statistical measures of the individual markers (e.g., match probabilities, likelihood ratios, and probability of inclusion) can be directly multiplied together to achieve high discriminating power. In fact, some common markers may not be strictly independent. For example, the short tandem repeat (STR) loci vWA and D12S391 are only ~6.36 million bases (Mb) apart and demonstrate linkage [1].Many studies have been conducted to investigate the dependencies among the common forensic markers, and a number of linked marker pairs have been identified, which can have an impact on statistical calculations [2][3][4][5][6][7][8][9][10][11]. Accordingly, the statistical calculation and interpretation of these dependent markers may need to be adjusted [4,[12][13][14][15].

show abstract