Accompagnement des dépendances à l’alcool et au tabac des patients atteints d’un cancer des voies aérodigestives supérieures

Hamant, Chloé; Deneuve, Sophie; Albaret, Marie-Alexandra; Zrounba, Philippe; Breton, P.; Céruse, Philippe; Gleizal, A.; Alix, T.; Bettega, G.; Chauvin, Franck; Saintigny, Pierre; Regnier, V.

doi:10.1016/j.bulcan.2018.07.006

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…Less than 1% of patients treated for cancer reported that they were informed about appointments to help with tobacco dependence or possible support in the management of alcohol consumption. Healthcare professionals involved in the cancer care pathways did not seem invested in the opportunity to support patients with this type of care, complementary to the treatment of their cancer [22]. The professionals interviewed in this qualitative study corroborated these facts.…”

Section: Care Centered On Cancer At the Expense Of Addiction Managementsupporting

confidence: 57%

“…Hamant et al conducted one of the few French studies of dealing with alcohol and tobacco addiction in patients undergoing treatment for ear, nose or throat cancer [22]. Less than 1% of patients treated for cancer reported that they were informed about appointments to help with tobacco dependence or possible support in the management of alcohol consumption.…”

Section: Care Centered On Cancer At the Expense Of Addiction Managementmentioning

confidence: 99%

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Managing unresolved issues of addiction during cancer treatment: A qualitative study about cancer care providers’ representations

et al. 2020

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Objective Five French oncology institutions had participated in a funded study aiming at implementing an Evidence-Based Practice tool (PAM-13), which allowed nurses to measure the level of activation of the patient to support his or her own empowerment in the cancer care pathway. The purpose of this ancillary study is to (i) describe the caregivers’ perceptions of addictions and their management concurrently with cancer treatment, (ii) explore the role that Motivational Interviewing techniques can play. Methods 15 individual semi-structured interviews of caregivers were performed, using the Theoretical Domains Framework for the interview guide. Qualitative data were analyzed inductively, in a thematic analysis. The COREQ guided the reporting of this qualitative study. Results Views on addictions influence the way caregivers manage patients suffering from unresolved issues of addiction. Care is mainly focused on the pathology (cancer-centered) and strictly curative. When practiced, Motivational Interviewing is patient-centered, fostering the patient’s empowerment on the cancer care pathway. Conclusions The dissemination of Motivational Interviewing techniques in current practices in oncology, both in terms of doctors and nursing teams, would enable improvement to the management of addictions on the cancer care pathway, by deploying a patient-centered approach. This new paradigm of care would support the empowerment of patients enrolled in the cancer care pathway and promote better communication between caregivers and patients. Hence, a paradigm shift is essential. Motivational Interviewing techniques could provide a caring approach that promotes communication between the patient and the caregiver and also supports the former’s empowerment. This research suggests the need to adapt the cancer care pathway in order to integrate the necessary care for patients who concomitantly suffer from unresolved addictive disorders. Trial registration NCT03706937

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Section: Care Centered On Cancer At the Expense Of Addiction Managementsupporting

confidence: 57%

Section: Care Centered On Cancer At the Expense Of Addiction Managementmentioning

confidence: 99%

Managing unresolved issues of addiction during cancer treatment: A qualitative study about cancer care providers’ representations

et al. 2020

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“…In clinical practice, only 0.9% of patients with cancer were informed about the possibility to get help in reducing excessive alcohol consumption [ 44 ]. In addition, the few published clinical studies are retrospective.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of chronic alcohol exposure-induced aggressiveness in cellular model of HCC and recovery after alcohol withdrawal

Marie

Fouquet

Courtois

et al. 2022

Cell. Mol. Life Sci.

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Alcohol-related liver disease is the most prevalent chronic liver disease worldwide, accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths. However, the knowledge on mechanisms by which alcohol consumption leads to cancer progression and its aggressiveness is limited. Better understanding of the clinical features and the mechanisms of alcohol-induced HCC are of critical importance for prevention and the development of novel treatments. Early stage Huh-7 and advanced SNU449 liver cancer cell lines were subjected to chronic alcohol exposure (CAE), at different doses for 6 months followed by 1-month alcohol withdrawal period. ADH activity and ALDH expression were much lower in SNU449 compared with Huh-7 cells and at the 270 mM dose, CAE decreased cell viability by about 50% and 80%, respectively, in Huh-7 and SNU449 cells but induced mortality only in Huh-7 cells. Thus, Huh-7 may be more vulnerable to ethanol toxicity because of the higher levels of acetaldehyde. CAE induced a dose-dependent increase in cell migration and invasion and also in the expression of cancer stem cells markers (CD133, CD44, CD90). CAE in Huh-7 cells selectively activated ERK1/2 and inhibited GSK3β signaling pathways. Most of the changes induced by CAE were reversed after alcohol withdrawal. Interestingly, we confirmed the increase in CD133 mRNA levels in the tumoral tissue of patients with ethanol-related HCC compared to other HCC etiologies. Our results may explain the benefits observed in epidemiological studies showing a significant increase of overall survival in abstinent compared with non-abstinent patients.

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Cancer survivors’ views on digital support for smoking cessation and alcohol moderation: a survey and qualitative study

et al. 2021

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Background Digital interventions may provide low-threshold support for smoking cessation (SC) and alcohol moderation (AM) to the growing population of cancer survivors. The objective was to explore preconditions of successful AM and SC digital interventions for cancer survivors. Methods Using a multi-method approach we conducted a survey (n = 240), a qualitative study consisting of four focus groups (n = 15) and semi-structured interviews with Dutch cancer survivors (n = 8). To help interpretation of our results we interviewed experts in the field of eHealth and cancer survivors (n = 6) and we organized an expert meeting (n = 7). Qualitative data were analysed using the Framework approach and were double-coded by two coders. Results Survey results show the majority of drinkers had not previously considered AM (n = 158, 84.9%), often because they deemed their alcohol use to be non-problematic. All current smokers in the survey had considered SC before. In focus groups and interviews it became clear that SC efforts did not always stem from their own willingness to quit smoking, but originated from a wish to please their social environment. Main themes to be addressed in digital SC and AM that emerged from the interviews and focus groups, centred on the different ways of identification as cancer survivors, need for autonomy, differential beliefs about SC and AM, and the importance of a positive, non-patronizing tone-of-voice. Several specific preferences for digital interventions were formulated, although some cancer survivors prefer no support or face-to-face contact. Conclusions Cancer survivors are a diverse group with diverse preferences for AM and SC support. Digital AM and SC interventions for cancer survivors are perceived to be of value by some, especially when they incorporate a positive, non-judgemental and non-patronizing tone-of-voice, address concerns specifically relevant to cancer survivors, offer possibilities for personalization, and emphasize autonomy throughout. To encourage AM specifically, problem recognition and awareness of the health benefits of AM should be improved.

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Accompagnement des dépendances à l’alcool et au tabac des patients atteints d’un cancer des voies aérodigestives supérieures

Cited by 7 publications

References 17 publications

Managing unresolved issues of addiction during cancer treatment: A qualitative study about cancer care providers’ representations

Managing unresolved issues of addiction during cancer treatment: A qualitative study about cancer care providers’ representations

Mechanisms of chronic alcohol exposure-induced aggressiveness in cellular model of HCC and recovery after alcohol withdrawal

Cancer survivors’ views on digital support for smoking cessation and alcohol moderation: a survey and qualitative study

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