Accommodative Function of Eyes in Persons Exposed to Ionizing Radiation

Sergienko, Nikolai M.; Fedirko, P.

doi:10.1159/000063879

Cited by 10 publications

(5 citation statements)

References 3 publications

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“…Epidemiological studies have provided clear evidence regarding the potential risks of radiation-associated lens changes in the eyes of workers occupationally exposed to IR (Jacob et al, 2010;Vano et al, 2010;Ciraj-Bjelac et al, 2012). It is known that accommodative capability of the eye depends on an individual's age, the absorbed dose, and duration of IR exposure (Sergienko and Fedirko, 2002); in individuals exposed to various doses of IR, it was found to be reduced in younger patients. However, Auvinen et al (2015) reported that the frequency of lens opacities did not increase in physicians with occupational exposure to IR.…”

Section: Discussionmentioning

confidence: 99%

Cytogenetic evaluation of cataract patients occupationally exposed to ionizing radiation in northeast China

Yao

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Long-term radiation exposure is hazardous to health; late-onset effects of exposure to ionizing radiation (IR) pose risks to the lens, and are associated with other non-cancerous diseases. Individuals occupationally exposed to low-dose IR are prone to developing eye cataracts. Cytogenetic evaluations suggest that IR is associated with chromosomal aberrations in occupationally exposed individuals. However, data regarding the association between chromosomal aberrations in cataract patients and occupational exposure to IR is scarce. Therefore, we aimed to report the characteristics of chromosomal aberrations in cataract patients from a Chinese population, occupationally exposed to IR. We found that the average age and frequency of numerical chromosomal aberrations were significantly lower in the exposed patients as compared with that in the non-exposed patients. In addition, the frequencies of dicentric and acentric chromosomes were significantly higher in the exposed patients as compared with those in the non-exposed patients. Therefore, chronic occupational exposure to IR affects cataract development in the Chinese population. The age of cataract patients exposed to IR was significantly lower than the age of cataract onset in normal individuals. Based on this study, we suggest that there is an urgent need for improved radiation safety and eye protection in individuals exposed to IR in the work place.

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Section: Discussionmentioning

confidence: 99%

Cytogenetic evaluation of cataract patients occupationally exposed to ionizing radiation in northeast China

Yao

et al. 2016

Genet. Mol. Res.

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“…7. Individuals from contaminated territories and liquidators had a marked decrease in ocular accommodation (Sergienko and Fedirko, 2002).…”

Section: Ukrainementioning

confidence: 95%

5. Nonmalignant Diseases after the Chernobyl Catastrophe

Yablokov¹

2009

Annals of the New York Academy of Sciences

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This section describes the spectrum and the scale of the nonmalignant diseases that have been found among exposed populations. Adverse effects as a result of Chernobyl irradiation have been found in every group that has been studied. Brain damage has been found in individuals directly exposed--liquidators and those living in the contaminated territories, as well as in their offspring. Premature cataracts; tooth and mouth abnormalities; and blood, lymphatic, heart, lung, gastrointestinal, urologic, bone, and skin diseases afflict and impair people, young and old alike. Endocrine dysfunction, particularly thyroid disease, is far more common than might be expected, with some 1,000 cases of thyroid dysfunction for every case of thyroid cancer, a marked increase after the catastrophe. There are genetic damage and birth defects especially in children of liquidators and in children born in areas with high levels of radioisotope contamination. Immunological abnormalities and increases in viral, bacterial, and parasitic diseases are rife among individuals in the heavily contaminated areas. For more than 20 years, overall morbidity has remained high in those exposed to the irradiation released by Chernobyl. One cannot give credence to the explanation that these numbers are due solely to socioeconomic factors. The negative health consequences of the catastrophe are amply documented in this chapter and concern millions of people.

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“…Доведено, що у дорослого населення радіаційний вплив спричиняє прискорене старіння органа зору, що виявляється, зокрема, у дозозалежному зниженні акомодаційної здатності [94]. При обстеженні стану ока у дитячого населення радіоактивно забруднених територій, тобто в зонах, де населення зазнає радіаційного впливу у відносно невеликих дозах (найбільшим дозове навантаження було у 1986 році) [95][96][97][98][99] nia risk increase after the prenatal diagnostic X ray in the Jerusalem cohort [86,87].…”

Section: Radiation Cerebro Ophthalmic Effects In Children and In Utero Irradiated Peopleunclassified

“…It has been proven that in the adult population, radiation exposure causes accelerated aging of the visual organ, which is manifested, in particular, in a dose dependent decrease in accommodation capac ity [94]. When examining the condition of the eye in children, radiation contaminated areas, i.e.…”

Section: Radiation Cerebro Ophthalmic Effects In Children and In Utero Irradiated Peoplementioning

confidence: 99%

Brain and Eye as Potential Targets for Ionizing Radiation Impact: Part Ii – Radiation Cerebro-Ophtalmic Effects in Children, Persons Exposed in Utero, Astronauts and Interventional Radiologists

Loganovsky¹,

Fedirko²,

Marazziti³

et al. 2021

Probl Radiac Med Radiobiol

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Background. Ionizing radiation (IR) can affect the brain and the visual organ even at low doses, while provoking cognitive, emotional, behavioral, and visual disorders. We proposed to consider the brain and the visual organ as potential targets for the influence of IR with the definition of cerebro-ophthalmic relationships as the «eye-brain axis». Objective. The present work is a narrative review of current experimental, epidemiological and clinical data on radiation cerebro-ophthalmic effects in children, individuals exposed in utero, astronauts and interventional radiologists. Materials and methods. The review was performed according to PRISMA guidelines by searching the abstract and scientometric databases PubMed/MEDLINE, Scopus, Web of Science, Embase, PsycINFO, Google Scholar, published from 1998 to 2021, as well as the results of manual search of peer-reviewed publications. Results. Epidemiological data on the effects of low doses of IR on neurodevelopment are quite contradictory, while data on clinical, neuropsychological and neurophysiological on cognitive and cerebral disorders, especially in the left, dominant hemisphere of the brain, are nore consistent. Cataracts (congenital – after in utero irradiation) and retinal angiopathy are more common in prenatally-exposed people and children. Astronauts, who carry out longterm space missions outside the protection of the Earth’s magnetosphere, will be exposed to galactic cosmic radiation (heavy ions, protons), which leads to cerebro-ophthalmic disorders, primarily cognitive and behavioral disorders and cataracts. Interventional radiologists are a special risk group for cerebro-ophthalmic pathology – cognitive deficits, mainly due to dysfunction of the dominant and more radiosensitive left hemisphere of the brain, and cataracts, as well as early atherosclerosis and accelerated aging. Conclusions. Results of current studies indicate the high radiosensitivity of the brain and eye in different contingents of irradiated persons. Further research is needed to clarify the nature of cerebro-ophthalmic disorders in different exposure scenarios, to determine the molecular biological mechanisms of these disorders, reliable dosimetric support and taking into account the influence of non-radiation risk factors. Key words: ionizing radiation, brain, eye, cerebro-ophthalmic effects, radiation emergencies, prenatal irradiation, space flights, interventional radiology.

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Accommodative Function of Eyes in Persons Exposed to Ionizing Radiation

Cited by 10 publications

References 3 publications

Cytogenetic evaluation of cataract patients occupationally exposed to ionizing radiation in northeast China

Cytogenetic evaluation of cataract patients occupationally exposed to ionizing radiation in northeast China

5. Nonmalignant Diseases after the Chernobyl Catastrophe

Brain and Eye as Potential Targets for Ionizing Radiation Impact: Part Ii – Radiation Cerebro-Ophtalmic Effects in Children, Persons Exposed in Utero, Astronauts and Interventional Radiologists

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