This chapter assesses scorpionism and noxious scorpions in Central America and the Caribbean area, scarcely surveyed previously despite the presence of potentially dangerous scorpions of the genera Centruroides and Tityus, family Buthidae. In Central America, most scorpion stings in Guatemala, Belize, El Salvador, Honduras, Nicaragua, Costa Rica, and Panama are caused by Centruroides spp. which are mildly toxic to humans, including C. edwardsii, C. granosus, and C. gracilis, with the highest regional morbidity corresponding to Panama. Lethal Tityus species from Panama are T.