Background: With the introduction of ridesharing through cell phone applications, the shape of transport systems has changed dramatically. An emergent group of studies have examined the extent under which ridesharing may decrease alcohol-related crashes in countries such as United States, United Kingdom, Canada, and Chile. Virtually all existent studies have assumed that ridesharing is equally distributed across socioeconomic groups, potentially masking differences across them. In this study, we exploit differences across different socioeconomic groups of municipalities in a highly segregated city such as Santiago, Chile to test whether, in the first year of Uber, this transport service was associated with changes in rates of fatal and injury alcohol-related crashes within municipalities. We used this period because Uber could only be paid with credit card. In Chile, this device is limited almost exclusively to high socioeconomic individuals.Methods: We apply spatial and rate ratio statistical analyses. Results: In both analyses, we find that the first year of Uber in Santiago is associated with significant rate ratio decreases (RR = 0.71 [95% Confidence Interval (C.I.) 0.56, 0.89]) in high socioeconomic municipalities in all alcohol-related crashes and null (RR = 1.10 [95% C.I. 0.97, 1.23]) increases in low socioeconomic municipalities. No concomitant associations were observed in fatal alcohol-related crashes regardless of the socioeconomic municipality group.Conclusions: One interpretation for the decline in alcohol-related crashes in high socioeconomic municipalities is that Uber may be a substitute form of transport for those individuals who have access to credit cards, and thus, could afford to pay for this service at the time they have consumed alcohol. Slight increases of alcohol-related crashes in low socioeconomic municipalities suggest that this association may be a function of alcohol consumption, in tandem with limited access to public transport alternatives within these territories.