“…8 Previous evaluations of vaginal self-collection have demonstrated a high prevalence of CT infection among young, sexually active women in both clinical and nontraditional settings. 8,9 Studies assessing acceptability for vaginal self-sampling have previously demonstrated high agreement between self-collected vaginal (SCV) and physician-collected vaginal (PCV) samples for the detection of CT and NG infections, with participants reporting high levels of acceptability, ease, and comfort during the selfcollection process. [10][11][12] Despite widespread evidence on the diagnostic effectiveness of vaginal self-sampling for the detection of STI's using nucleic acid amplification tests, [13][14][15] there is a growing need to evaluate self-collection devices for ease and comfort, particularly for home-based applications.…”