Acceptability and Disintegration Rates of Orally Disintegrating Risperidone Tablets in Patients with Schizophrenia or Schizoaffective Disorder

Chue, Pierre; Welch, Ronald W.; Binder, Carin

doi:10.1177/070674370404901009

Cited by 30 publications

(16 citation statements)

References 10 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with this condition frequently show resistance to medical treatments, especially because of the unpleasant side effects and the objection to ingest traditional solid dosage forms, such as tablets [12,13]. Additionally, according to biopharmaceutical classification system (BCS), RISP is a class II compound, which means that it has poor water solubility and, consequently, a dissolution rate-limited absorption through the gastrointestinal tract (GIT) [14].…”

mentioning

confidence: 99%

Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound

Silva

González‐Mira

García

et al. 2011

Colloids and Surfaces B: Biointerfaces

237

View full text Add to dashboard Cite

mentioning

confidence: 99%

Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound

Silva

González‐Mira

García

et al. 2011

Colloids and Surfaces B: Biointerfaces

237

View full text Add to dashboard Cite

“…Surreptitious rejection of medication by patients occurs sometimes in clinical practice [15]. If a tablet is swallowed and the pH becomes more acidic, the olanzapine will dissolve more rapidly than in the more neutral pH of saliva; however, the time for complete disintegration may be no better than in the mouth.…”

Section: Discussionmentioning

confidence: 99%

“…For olanzapine Zydis ® ODT, the elapsed time for initial and complete disintegration was measured in two small in vivo studies [14, 15]. However, these studies used different methods: one took the first measurement of initial disintegration at 15 s, while the other took the first measurement at 5 s. It is desirable to compare disintegration times among different products using the same methodology.…”

Section: Introductionmentioning

confidence: 99%

An In Vitro Analysis of Disintegration Times of Different Formulations of Olanzapine Orodispersible Tablet: A Preliminary Report

et al. 2013

View full text Add to dashboard Cite

BackgroundOrodispersible tablets (ODTs) are tablet or wafer forms of medication that disintegrate in the mouth, aided only by saliva. ODTs rely on different fast dissolve/disintegration manufacturing technologies.ObjectivesDisintegration time differences for several olanzapine ODT forms were investigated. Risperdal M-Tab® was included as a non-olanzapine ODT comparator.Research Design and MethodsEleven olanzapine ODT examples and orodispersible risperidone strengths were evaluated in vitro for formulation composition, manufacturing method, disintegration and dissolution characteristics, and formulation differences in comparison with freeze dried Zydis® ODT. Automated dissolution test equipment captured ODT dissolution rates by measuring real-time release of active ingredient. A high-speed video camera was used to capture tablet disintegration times in warm simulated saliva.Main Outcome MeasureThe main outcome measure was the disintegration and dissolution characteristics of the ODT formulations.ResultsThe ODT manufacturing method was associated with time to disintegrate; the fastest were freeze dried tablets, followed by soft compressed tablets and then hard/dense tablets. Olanzapine Zydis® was the only ODT that completely disintegrated in less than 4 s for all strengths (5, 10, 15, and 20 mg), followed by 5-mg Prolanz FAST® (12 s) and then risperidone ODT 4 mg (40 s). Reasons for slow dissolution of the olanzapine generics may include low product potency, excipient binding, excipient solubility, active ingredient particle size and incomplete disintegration.ConclusionsDifferences in the formulation and manufacturing process of olanzapine ODTs appear to have a strong influence on the disintegration time of the active compound; differences that may potentially impact their use in clinical practice.Electronic supplementary materialThe online version of this article (doi:10.1007/s40268-013-0030-8) contains supplementary material, which is available to authorized users.

show abstract

“…The fast dissolving tablets disintegrates instantaneously when placed on tongue and releases the drug dissolve or disperses in saliva 1 . The fast dissolving tablets are useful in patients [2][3] , like pediatric, geriatric, bedridden or mentally disabled, who may face difficulty in swallowing conventional tablet or capsule 4 leading to ineffective therapy 5 . Most pharmaceutical forms for oral administration are formulated for direct ingestion or for chewing or for prior dispersion/dissolution in water.…”

Section: Introductionmentioning

confidence: 99%

Design and Development of Taste Masked Oral Disintegrating Tablet of Ondansetron Hydrochloride

Rao¹,

Nayak²,

Kumar³

et al. 2016

Int. Res. J. Pharm.

View full text Add to dashboard Cite

Ondansetron HCl is effective in the treatment of nausea and vomiting caused in such condition it is difficult to administer drug with a glass of water; hence it is beneficial to administer such drugs as orodispersible. Thus in the present study an attempt has been made to mask the taste of Ondansetron HCl and to formulate orodispersible with good mouth feel so as to prepare a "patients friendly dosage form.". The tablets prepared by sublimation method. The prepared tablets were evaluated for various pharmaceutical characteristics such as hardness, % friability, weight variation, drug content all the results were within the IP. Limit. The tablets prepared possess a weight variation in the range 99 to 101 mg which is below ± 7.5%, hardness of 2.7 to 3.0 kg/cm², percentage friability of 0.42 to 0.73%. The wetting time of Ondansetron HCl fast dissolving tablets was found to be in the range of 44 to 81 sec. The prepared formulations shows water absorption ratio in the range of 72 to 85%. The percentage drugs content of the tablets were found to be between 98.24 to 101.20% of Ondansetron HCl. In-vitro disintegration time the formulations OHS4 and OHS8 were found to be promising and showed a 28 sec and 32 sec respectively. Based on the in-vitro disintegration time and dissolution studies formulations OHS4 and OHS8 were found to be promising and showed a disintegration time of 28 sec and 32 sec respectively. Formulation OHS4 containing camphor showed highest drug release 99% within 8 min. Formulation OHS8 showed highest drug release 90% within 8 min. From FTIR and DSC study results reveals that there is no interaction between drug and any other formulation excipients. In case of stability study there is decrease in disintegration time, wetting time was observed. The results concluded that fast dissolving tablets of Ondansetron HCl showing enhanced dissolution will lead to improved bioavailability and effective therapy. This drug resin complex was compressed in tablets by adding diluents to see its mouth feel properties and bitter taste is masked.

show abstract

Acceptability and Disintegration Rates of Orally Disintegrating Risperidone Tablets in Patients with Schizophrenia or Schizoaffective Disorder

Abstract: The orally disintegrating risperidone tablets were well tolerated and rated as very acceptable by all patients.

Cited by 30 publications

References 10 publications

Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound

Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound

An In Vitro Analysis of Disintegration Times of Different Formulations of Olanzapine Orodispersible Tablet: A Preliminary Report

Design and Development of Taste Masked Oral Disintegrating Tablet of Ondansetron Hydrochloride

Contact Info

Product

Resources

About