Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound

Silva, Ana Catarina; González‐Mira, Elisabet; García, María L.; Egea, M.A.; Fonseca, Joel; Silva, R.; Santos, Delfim; Souto, Eliana B.; Ferreira, Domingos

doi:10.1016/j.colsurfb.2011.03.035

Cited by 240 publications

(112 citation statements)

References 35 publications

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“…The average values over six DSC scans of the melting temperature (Tm) and the enthalpy of fusion at the melting temperature (Δ fus H) of form I are given in Table 2. The value of T m determined in this work as the mean extrapolated onset temperature (442.4 K) is slightly less than the value reported by Silva et al [6] (443.6 K), and slightly higher than those reported by Germann et al [1] (441.8 K) and Shah et al [7] (439.9 K), although it should be noted that these studies all used risperidone of unspecified or lower purity, higher heating rates (5-10 K min -1 ), and give no estimate on the confidence of their data. The value of the melting enthalpy determined here (43.94 kJ mol -1 ) is slightly lower than the value reported by Silva et al [6] (45.28 kJ mol -1 ).…”

Section: Thermal Analysiscontrasting

confidence: 49%

Thermodynamics of risperidone and solubility in pure organic solvents

Mealey

Svärd

Rasmuson

2014

Fluid Phase Equilibria

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The solid-liquid solubility of the thermodynamically stable form I of the drug risperidone has been determined by a gravimetric method in nine pure organic solvents in the temperature range 278.15-323.15 K. The melting temperature and associated enthalpy of fusion of risperidone form I has been determined by differential scanning calorimetry (DSC) to be 442.38 K and 43.94 kJ mol -1 , respectively. The heat capacity of the solid form I and the melt have been determined over a range of temperatures by temperature-modulated DSC, and extrapolated data has been used to calculate the Gibbs energy, enthalpy and entropy of fusion from ambient temperature up to the melting point. The ideal solubility within a Raoult's law framework is obtained from the Gibbs energy of fusion, and the solution activity coefficient at equilibrium in the nine solvents quantified. Solutions in all solvents exhibit positive deviation from Raoult's law, with the highest solubility (closest to ideality) in toluene, an aprotic apolar solvent. The solubility curves plotted in a van't Hoff graph show non-linear behaviour and are well-approximated by a second order polynomial.

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Section: Thermal Analysiscontrasting

confidence: 49%

Thermodynamics of risperidone and solubility in pure organic solvents

Mealey

Svärd

Rasmuson

2014

Fluid Phase Equilibria

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“…13 In brief, the lipid phase, consisting of Compritol 888 ATO (3% w/w) and FMO (2% w/w), was heated to 5°C-10°C above the melting point of Compritol 888 ATO. The aqueous phase containing a mixture of surfactants (soybean lecithin, 2% w/w and Tween 80, 2% w/w) in double-distilled water was s imultaneously prepared at the same temperature.…”

Section: Preparation Of Fmo-slnsmentioning

confidence: 99%

Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

Shi

Zhao²,

Liu³

et al. 2012

IJN

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Abstract:The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the oral delivery of frankincense and myrrh essential oils (FMO). Aqueous dispersions of SLNs were successfully prepared by a high-pressure homogenization method using Compritol 888 ATO as the solid lipid and soybean lecithin and Tween 80 as the surfactants. The properties of the SLNs such as particle size, zeta potential (ZP), and drug encapsulation efficiency (EE) were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM). The crystallinity of the formulation was analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, drug evaporation release and antitumor activity were also studied. Round SLNs with a mean size of 113.3 ± 3.6 nm, a ZP of −16.8 ± 0.4 mV, and an EE of 80.60% ± 1.11% were obtained. DSC and XRD measurements revealed that less ordered structures were formed in the inner cores of the SLN particles. Evaporation loss of the active components in FMO could be reduced in the SLNs. Furthermore, the SLN formulation increased the antitumor efficacy of FMO in H22-bearing Kunming mice. Hence, the presented SLNs can be used as drug carriers for hydrophobic oil drugs extracted from traditional Chinese medicines.

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“…The NLC dispersions were prepared according to the method previously employed by Silva et al 16 Briefly, the lipids were heated at 5°C-10°C above the melting point of the solid lipid (56°C). At the same time, the aqueous phase, composed of surfactant, preservative, and purified water, was heated at the same temperature.…”

Section: Preparation Of Nlc Dispersionsmentioning

confidence: 99%

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Tichota¹,

Silva²,

Lobo³

et al. 2014

IJN

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Given its advantages in skin application (eg, hydration, antiaging, and protection), argan oil could be used in both dermatological and cosmetic formulations. Therefore, the preparation of nanostructured lipid carriers (NLCs) using argan oil as a liquid lipid is a promising technique, since the former constitute well-established systems for dermal delivery. The aim of this work was to develop a topical formulation of argan oil NLCs to improve skin hydration. Firstly an NLC dispersion was developed and characterized, and afterward an NLC-based hydrogel was prepared. The in vivo evaluation of the suitability of the prepared formulation for the proposed application was assessed in volunteers, by measuring different skin-surface parameters for 1 month. An argan oil NLC-based hydrogel formulation was successfully prepared and characterized. Moreover, the entrapment of the NLCs in the hydrogel net did not affect their colloidal sizes. Additionally, it was observed that this formulation precipitated an increase in skin hydration of healthy volunteers. Therefore, we concluded that the preparation of NLC systems using argan oil as the liquid lipid is a promising strategy, since a synergistic effect on the skin hydration was obtained (ie, NLC occlusion plus argan oil hydration).

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Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound

Cited by 240 publications

References 35 publications

Thermodynamics of risperidone and solubility in pure organic solvents

Thermodynamics of risperidone and solubility in pure organic solvents

Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

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