Accelerometric comparison of the locomotor pattern of horses sedated with xylazine hydrochloride, detomidine hydrochloride, or romifidine hydrochloride

López‐Sanromán, Javier; Holmbak-Petersen, R.; Varela, M.; Álamo, Ana M del; Santiago, I.

doi:10.2460/ajvr.74.6.828

Cited by 22 publications

(28 citation statements)

References 31 publications

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“…There is currently no alternative (reversible) equine model in which to study ataxia. A side effect of α‐2 agonists is induction of ataxia ; 2 significant advantages of a xylazine‐induced equine ataxia model are that the resulting ataxia is dose‐dependent, as seen here and as has been reported previously , and the mechanism of development of the gait deficits is the same across animals. Here, all HD horses were graded 3 and LD horses were grade 1 or 2 for ataxia.…”

Section: Discussionsupporting

confidence: 74%

Objective assessment of gait in xylazine‐induced ataxic horses

Nout‐Lomas

Page

Kang

et al. 2016

Equine Veterinary Journal

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Administration of xylazine induced a dose-dependent ataxia in horses and resulted in significant changes of gait parameters, pelvic accelerations, and stabilographic variables, some of which changed in a dose-dependent fashion. Some of the altered gait parameters in this model were probably a result of overall slowing down of the stride cycle secondary to the sedative effect. Continued efforts to discover and evaluate quantifiable gait parameters that are susceptible to change following development of clinical neurological disease in horses is warranted.

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Section: Discussionsupporting

confidence: 74%

Objective assessment of gait in xylazine‐induced ataxic horses

Nout‐Lomas

Page

Kang

et al. 2016

Equine Veterinary Journal

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“…Gait patterns measured using 3‐dimensional accelerometry were altered by either intravenous xylazine, detomidine or romifidine (López‐Sanromán et al . ) or sublingual detomidine (López‐Sanromán et al . ).…”

Section: General Principlesmentioning

confidence: 99%

Where does it hurt? Problems with interpretation of regional and intra‐synovial diagnostic analgesia

Pilsworth

Dyson

2015

Equine Veterinary Education

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Summary Detailed clinical evaluation and diagnostic analgesia are crucial for accurate lameness diagnosis. This review discusses the ways in which local analgesic techniques can cause confusion and highlights how important it is to recognise that the majority of methods are less specific than was formerly thought. Interpretation of responses must be done together with the results of clinical examination and careful assessment of diagnostic images. With the knowledge of false negative and false positive results of local analgesic techniques and the recognition that there may be more than one focus of pain contributing to lameness, it is still possible to reach accurate diagnoses, provided that a logical, thoughtful approach is utilised.

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“…Effects of romifidine (40 µg/kg IV) on stride frequency were noted for 90 min compared with only 30 min for xylazine and detomidine. Speed was reduced for up to 105 min with romifidine, compared with 30–45 min for xylazine and detomidine, respectively . Romifidine may be a good choice in situations where a horse's balance and coordination are important, but a sustained sedative effect is still desired, such as traveling in a trailer.…”

Section: Introductionmentioning

confidence: 99%