Acceleration of fibroblast number and FGF-2 expression using Channa striata extract induction during wound healing process: in vivo studies in wistar rats

Oentaryo, Gunawan; Istiati, Istiati; Soesilawati, Pratiwi

doi:10.20473/j.djmkg.v49.i3.p125-132

Cited by 6 publications

(10 citation statements)

References 9 publications

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“…5 Isa et al (2016) which were administered orally to the subjects (Saleem et al, 2013;Ali Khan et al, 2014;Wahab et al, 2015;Bakar et al, 2015;Oentaryo et al, 2016;Shukkoor et al, 2016;Azidah et al, 2017;Shafii et al, 2017;Azemi et al, 2018;Sahid et al, 2018;Susibalan et al, 2018;Ma'rufi et al, 2019). Meanwhile, in studies done by Baie and Sheikh (2000a;2000b) and Isa et al (2016), Channa striatus cream was applied on wounds, whereas Channa striatus spray was described by Laila et al (2011).…”

Section: Search Resultsmentioning

confidence: 99%

“…However, Azemi et al (2018) found that antiulcer activity was reversed by pre-treated N-ethylmaleimide (NEM). A study done by Oentaryo et al (2016) found that Channa striatus administration to the rats increased the number of fibroblasts and FGF-2 expression as compared to the control group during wound healing.…”

Section: In Vivo Channa Striatus Studies On Animalsmentioning

confidence: 97%

“…The studies on humans were conducted on women with post LSCS (Bakar et al, 2015;Wahab et al, 2015) and patients who underwent clean elective surgery (Sahid et al, 2018). Meanwhile, the studies on animals were conducted on rats with excision wounds (Baie and Sheikh, 2000b), incision wounds (Baie and Sheikh, 2000a;Laila et al, 2011), and wound creation on lower lips (Oentaryo et al, 2016).…”

Section: Effects Of Channa Striatus On Wound Healingmentioning

confidence: 99%

“…The wound healing process can also be enhanced by increasing the number of fibroblasts (Oentaryo et al, 2016). Fibroblasts enter the wound area two to five days after an injury occurred.…”

Section: Effects Of Channa Striatus On Wound Healingmentioning

confidence: 99%

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In vivo effects of Channa striatus on humans and animals: a systematic review

hadi¹,

Ooi²,

Kadir³

et al. 2021

IFRJ

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Channa striatus contains biochemical components and albumin, which elicit beneficial effects to the consumers. This review aimed to clarify the effects of Channa striatus consumption on humans and animals in in vivo studies. A systematic search in four electronic databases namely ProQuest, EBSCOhost, PubMed, and SpringerLink was performed to choose the studies on Channa striatus as the interventions, and its effects on animals and humans. The intervention involved: (i) Channa striatus with placebo-controlled, (ii) Channa striatus pre-treated and treated with drugs, (iii) Channa striatus with the combination of Chronic Unpredictable Mild Stress (CUMS), and (iv) Channa striatus pre-treated with amino acids and methylene blue. Thirteen animal studies and seven human studies were included in the final analysis. They investigated the effects of Channa striatus on wound healing, anti-depressant-like effects, anti-inflammatory effects, and effects on human diseases. Consumption of Channa striatus supplements was found in seven studies to benefit wound healing processes due to the contents of amino acids and fatty acids found in Channa striatus extract. Two studies were found regarding Channa striatus lipid decreased the corticosterone level and nuclear factor-kappa B, while two studies reported of DHA content in Channa striatus inhibited the production of inflammatory mediators. Channa striatus elicits a positive effect on the wound healing process and enhanced antidepressant-like and anti-inflammatory effects due to its high content of amino acids and fatty acids.

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Section: Search Resultsmentioning

confidence: 99%

Section: In Vivo Channa Striatus Studies On Animalsmentioning

confidence: 97%

Section: Effects Of Channa Striatus On Wound Healingmentioning

confidence: 99%

“…The wound healing process can also be enhanced by increasing the number of fibroblasts (Oentaryo et al, 2016). Fibroblasts enter the wound area two to five days after an injury occurred.…”

Section: Effects Of Channa Striatus On Wound Healingmentioning

confidence: 99%

See 2 more Smart Citations

In vivo effects of Channa striatus on humans and animals: a systematic review

hadi¹,

Ooi²,

Kadir³

et al. 2021

IFRJ

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show abstract

“…Oentaryo et al have been carried out research about alternative medicine in the treatment of ischemic stroke and one of them is Ophiocephalus striatus sp. extract [3]. The potential nutrient possessed by O. striatus sp.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Ophiocephalus striatus sp. Extract on Nitric Oxide in Ischemic Stroke Model

Nasution

Sjahrir

Ichwan

2021

Open Access Maced J Med Sci

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BACKGROUND: One of alternative medicine in stroke therapy is Ophiocephalus striatus sp. extract. The nutrients contained in the O. striatus sp. extract, namely amino acids, fatty acids, cuprum, and zinc, are useful for the process of angiogenesis in poststroke patients through increased endothelial nitric oxide synthase. AIM: We hypothesized that there was an effect of giving O. striatus sp. extract to cerebral angiogenesis process of Sprague Dawley rats ischemic stroke models through the level of NO. METHODS: This was evidenced by conducting experimental studies on rats ischemic stroke models which were divided into five groups, (a) K (−) group (no ligation, no treatment), (b) K (+) group (ligation, no treatment), (c) P1 group (ligation, 200 mg extract), (d) P2 group (ligation, 400 mg extract), and (e) P3 group (ligation, 800 mg extract). Then blood sample was taken on day 3 to assess levels of NO. RESULTS: There was increased level of NO in P1 (p = 0.001), P2 (p < 0.001), and P3 (p < 0.001) groups compared to K (+) group. The level of NO increases along with the increasing dose of O. striatus sp. extract. Histological examination revealed that there was formation of new blood vessel in the P1, P2, and P3 groups compared to K (+) group. CONCLUSION: Our study showed that O. striatus sp. extract improves cerebral angiogenesis in rat models of ischemic stroke.

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The effect of snakehead fish extract on acute wound healing process in hyperglycemic rats

et al. 2022

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Introduction: Wound healing is an integrated response to tissue injury. A hyperglycemic state can lead to delayed wound healing process. Snakehead fish (Channa striata) is native freshwater fish of South East Asia that contains high protein, albumin, and several micronutrients. The aim of this study is to evaluate the efficacy of snakehead fish extract on acute wound healing process in streptozotocin-induced hyperglycemic rats. Methods: This study was an experimental trial on the hyperglycemic animal model. Thirty male Wistar streptozotocin-induced rats were divided into two groups which were then given snakehead fish extract (Pujimin Plus®) 81mg a day for 10 days after wound infliction in intervention group and carboxymethyl cellulose sodium (Na-CMC) in control group. On day 0, day 3, and day 10 after wound infliction, the histological changes (number of neutrophil and fibroblast, and vascular changes of the wounded tissues) of each group were analyzed. Assessments were also made on erythema and crust formation by the visual scores. Results: Our study showed a significant increase in the number of fibroblasts on day 3 in the snakehead fish extract group compared to control group (40.33 ± 10.13 vs. 24.60 ± 10.25, p =0.04). There were no significant differences in vasculature and neutrophil numbers. The results also showed snakehead fish extract could decrease mean erythema visual score on day 3 (3.24 ± 0.25 vs. 3.64 ± 0.35) and decreased crust formation on day 5 (3.36 ± 0.75 vs 3.44 ± 0.83). Conclusions: Snakehead fish extract has potential effect to accelerate the wound healing process by increasing fibroblast, decreasing erythema, and decreasing crust formation in streptozotocin-induced hyperglycemic rats.

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Acceleration of fibroblast number and FGF-2 expression using Channa striata extract induction during wound healing process: in vivo studies in wistar rats

Cited by 6 publications

References 9 publications

In vivo effects of Channa striatus on humans and animals: a systematic review

In vivo effects of Channa striatus on humans and animals: a systematic review

The Effect of Ophiocephalus striatus sp. Extract on Nitric Oxide in Ischemic Stroke Model

The effect of snakehead fish extract on acute wound healing process in hyperglycemic rats

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