Accelerating effects of genipin-crosslinked small intestinal submucosa for defected gastric mucosa repair

Abstract

GP-CR SIS was highly resistant to gastric juice digestion and had a great improvement in mechanical properties.

New Insight into Natural Extracellular Matrix: Genipin Cross-Linked Adipose-Derived Stem Cell Extracellular Matrix Gel for Tissue Engineering

“…The FTIR spectrum showed the typical bands of amide I, II, and III for the cross-linked ADSC ECM gel, and the presence of amide III relating to C-N stretching and NH reveals the triple helical structure of collagen is preserved [66,67]. Moreover, the spectrum of the cross-linked ADSC ECM gel showed a decrease in the characteristic peak of amine (-NH 2 ) stretch at 1541 cm −1 , and this result was consistent with genipin cross-linked tissue-derived ECM [68]. Furthermore, genipin cross-linking increased the stability of a human umbilical cord-derived ECM gel in a dose-dependent manner based on the conjugation of free amino groups of the ECM [45].…”

An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation

“…Gastric mucus is a glycoprotein that serves two purposes: the lubrication of food masses to facilitate movement within the stomach and the formation of a protective layer over the lining epithelium of the stomach cavity. The GP defected areas exposed to corrosive gastric juice may induce a slow-healing of gastric mucosa, which results in patients suffering from this complication [ 41 , 42 ]. Therefore, whether or not the mucosa fully regenerates is a health hallmark of stomach after GP treatment [ 43 , 44 ].…”

Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model

“…As a xenogeneic, acellular, biocompatible, biodegradable, and collagen-based scaffold, porcine SIS can enable bladder regeneration without ex vivo cell seeding before the implantation [ [40] , [41] , [42] , [43] ]. The particular biochemical components and excellent mechanical properties have conferred it with appropriate structure and microenvironment not only as a scaffold but also with specific physiological functions suitable for cell adhesion, proliferation, differentiation, and the ultimate tissue regeneration [ 35 , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] ].…”