Accelerated Red Blood Cell Turnover Can Invalidate the Use of Hemoglobin A1c as a Diagnostic Test for Cystic Fibrosis Related Diabetes

Hardin, Dana S.; Grilley, Kevin; Baron, Bruce M.; Hale, Kathryn

doi:10.1203/00006450-199904020-00537

Cited by 12 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glycosylated haemoglobin has previously been shown to be inappropriate for the diagnosis of CFRD compared with OGTT [8,19–21]. It is probably the reduced life span of red blood cells in CF which means that the HbA 1c will be lower for a given level of glycaemia [22]. It is likely HbA 1c will also underestimate glycaemic control in CF subjects with established diabetes and so lower targets may be required than in non‐CF subjects to achieve a similar degree of glycaemic control.…”

Section: Discussionmentioning

confidence: 99%

Conventional measures underestimate glycaemia in cystic fibrosis patients

2004

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Conventional measures underestimate glycaemia in cystic fibrosis patients

2004

View full text Add to dashboard Cite

show abstract

“…Hemoglobin A1c cannot be used alone as a screening mechanism, because it underestimates overall glycemic control and does not correlate well with OGTT results 37 , 43 . Individuals with CF can have increased red blood cell turnover, making hemoglobin A1c spuriously low in these patients 45 …”

Section: Cf‐related Diabetesmentioning

confidence: 99%

Nutrition Management of Cystic Fibrosis in the 21st Century

2015

View full text Add to dashboard Cite

Despite significant advancements made in life expectancy over the past century, cystic fibrosis remains a life-threatening genetic disease that affects the gastrointestinal tract, and it has significant impact on the nutrition status of those with the disease. Nutrition management includes a high-calorie/high-fat diet, pancreatic enzyme replacement therapy, vitamin and mineral replacement, and enteral support as needed. As patients are living longer, clinicians may encounter patients with cystic fibrosis in obstetrician offices, endocrine clinics, or hospital settings, owing to lung transplantation or for treatment for distal intestinal obstruction syndrome.

show abstract

“…A small study from Texas by Hardin et al 201 (abstract only) divided nine patients with CF and previously detected IGT into those with good pulmonary function (FEV 1 and FVC 82-92% predicted) and those with poor (FEV 1 and FVC 32-48% predicted). Red blood cell turnover was faster in those with poor function, which led them to conclude that HbA 1c level was not suitable as a screening test for CFRD.…”

Section: The Debate On the Use Of Glycated Haemoglobinmentioning

confidence: 99%

Screening for cystic fibrosis-related diabetes: a systematic review.

Waugh

Royle²,

Craigie³

et al. 2012

Health Technol Assess

View full text Add to dashboard Cite

How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects...

show abstract

Accelerated Red Blood Cell Turnover Can Invalidate the Use of Hemoglobin A1c as a Diagnostic Test for Cystic Fibrosis Related Diabetes

Cited by 12 publications

References 0 publications

Conventional measures underestimate glycaemia in cystic fibrosis patients

Conventional measures underestimate glycaemia in cystic fibrosis patients

Nutrition Management of Cystic Fibrosis in the 21st Century

Screening for cystic fibrosis-related diabetes: a systematic review.

Contact Info

Product

Resources

About