Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial

Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement

“…With a median follow-up of 5 years, 1.5% had an in-breast recurrence and age was not a significant factor associated with recurrence. 4 In each trial, roughly 90% or more of enrolled patients had T1, N0 and hormone-sensitive disease. Data from other large randomized phase 3 trials evaluating APBI, including the National Surgical Adjuvant Breast and Bowel Project B39/Radiation Therapy Oncology Group (RTOG) 0413 trial 5 and Randomized Trial of Accelerated Partial Breast Irradiation trials, 6 are pending.…”

“…15 In contrast, the University Florence phase 3 trial reported that IMRT APBI resulted in improved physician-rated cosmetic outcome compared with WBI. 4 Single-arm studies have also reported higher rates of fair to poor cosmetic outcomes in approximately 20% of patients treated with EBRT-based APBI. 29,36,37 However, other clinical series of APBI delivered with 3D-CRT or IMRT reported acceptable cosmetic outcomes.…”

Hypofractionated Whole-Breast Radiotherapy and Concomitant Boost after Breast Conservation in Elderly Patients

“…These results confirm the viability of omitting WBRT for indolent breast cancer, strengthening the application of this approach in the subset of elderly patients with no detrimental effects even on local control. Another option for this subset of patients is accelerated partial breast irradiation (APBI), which combines the possibility of sparing part of the breast tissue from irradiation with a more convenient treatment schedule (22). This approach would provide the possibility to offer WBRT with a potential benefit in terms of local control also to an elderly population, with a more favorable logistic profile.…”

Personalized radiotherapy for invasive breast cancer in 2017

“…Based on long-term results from three randomized studies, (accelerated) partial breast irradiation ((A)PBI) using intraoperative radiotherapy or postoperative multicatheter brachytherapy or external beam radiotherapy is an option for postmenopausal patients with low-risk tumors (T1N0, R0 resection, hormone receptor positive, non-lobular histology). Participation in a clinical study is recommended for patients between 50 and 70 years of age [10][11][12].…”